The effect of colon in metabolic surgery

• Project/Area Number: 15K19859
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: NISHI Masaaki 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (70464344)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肥満 / metabolic surgery / 大腸 / 大腸バイパス / DJB / 糖尿病 / NASH / microbiome / GLUT1 / 胆汁酸

Outline of Final Research Achievements

We herein investigated the role of metabolic surgery, especially in the colon, for the morbid obesity. Metabolic surgery (Duodeno-jejunal bypass)　had the effect for the nonalcoholic steatohepatitis, diabetes mellitus, and changed the gut microbiota. However, the colon bypass was not effective in our experiments

Research Products

• [Journal Article] Duodenal-jejunal bypass changes the composition of the gut microbiota. (2016)
  • Author(s): Kashihara H, Shimada M, Yoshikawa K, Higashijima J, Nakao T, Nishi M, Takasu C.
  • Journal Title: Surg Today. Volume: 19 Issue: 1 Pages: 137-140
  • DOI: 10.1007/s00595-016-1373-x
  • Peer Reviewed
• [Journal Article] Combined liver mobilization and retraction: A novel technique to obtain the optimal surgical field during laparoscopic total gastrectomy. (2016)
  • Author(s): Yoshikawa K, Shimada M, Higashijima J, Nakao T, Nishi M, Takasu C, Kashihara H, Eto S.
  • Journal Title: Asian J Endosc Surg. Volume: 印刷中 Issue: 2 Pages: 111-115
  • DOI: 10.1111/ases.12271
  • Peer Reviewed
• [Journal Article] Duodenal-jejunal bypass improves diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids. (2015)
  • Author(s): Kashihara H, Shimada M, Kurita N, Sato H, Yoshikawa K, Higashijima J, Chikakiyo M, Nishi M, Takasu C.
  • Journal Title: J Gastroenterol Hepatol. Volume: 30 Issue: 2 Pages: 308-315
  • DOI: 10.1111/jgh.12690
  • Peer Reviewed
• [Journal Article] The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer. (2015)
  • Author(s): Eto S, Yoshikawa K, Shimada M, Higashijima J, Tokunaga T, Nakao T, Nishi M, Takasu C, Sato H, Kurita N.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 2071-2076
  • Peer Reviewed
• [Journal Article] Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer. (2015)
  • Author(s): Nakao T, Iwata T, Hotchi M, Yoshikawa K, Higashijima J, Nishi M, Takasu C, Eto S, Teraoku H, Shimada M.
  • Journal Title: Oncol Rep. Volume: 34（4） Issue: 4 Pages: 1961-1967
  • DOI: 10.3892/or.2015.4196
  • Peer Reviewed
• [Presentation] 耐糖能異常・NAFLD/NASHに対するRoux en Y再建の効果 (2017)
  • Author(s): 柏原秀也, 島田光生, 吉川幸造, 東島潤, 西正暁, 高須千絵
  • Organizer: 第89回日本胃癌学会総会
  • Place of Presentation: 広島国際会議場(広島県広島市）
  • Year and Date: 2017-03-10
• [Presentation] 肥満の胃切除術への影響と肥満患者における治療成績改善への取り組み (2017)
  • Author(s): 吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 高須千絵, 石川大地, 吉川雅登
  • Organizer: 第89回日本胃癌学会総会
  • Place of Presentation: 広島国際会議場(広島県広島市）
  • Year and Date: 2017-03-09
• [Presentation] 胃切除術における肥満の影響と治療成績改善への取り組み (2017)
  • Author(s): 吉川幸造, 島田光生, 東島潤, 西正暁, 柏原秀也, 高須千絵, 石川大地, 吉川雅登
  • Organizer: 第25回徳島外科術後管理研究会
  • Place of Presentation: 徳島県医師会館(徳島県徳島市)
  • Year and Date: 2017-02-01
• [Presentation] A possible effect of metabolic surgery on diabetes and NASH. (2016)
  • Author(s): 柏原秀也, 島田光生, 吉川幸造, 東島潤, 中尾寿宏, 西正暁, 高須千絵.
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: アスティ徳島(徳島県徳島市)
  • Year and Date: 2016-07-16
• [Presentation] 直腸癌手術における縫合不全回避のための術中血流評価の有用性 (2015)
  • Author(s): 西正暁,島田光生,東島潤,吉川幸造,中尾寿宏,徳永卓哉,柏原秀也,髙須千絵
  • Organizer: 第24回日本コンピュータ外科学会大会
  • Place of Presentation: 東京大学本郷キャンパス（東京都文京区）
  • Year and Date: 2015-11-23
• [Presentation] 胃癌におけるPD-1発現の意義 (2015)
  • Author(s): 西正暁,島田光生,吉川幸造,東島潤,中尾寿宏,徳永卓哉,柏原秀也,髙須千絵,江藤祥平
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Resveratorol inhibit tumor growth of pancreatic cancer cell line via induction of apoptosis and autophagy (2015)
  • Author(s): 西正暁
  • Organizer: American college of surgeons
  • Place of Presentation: ＭｃＣｏｒｍｉｃｋ Ｐｌａｃｅ（Ｃhｉｃａｇｏ ＵＳＡ）
  • Year and Date: 2015-10-06
  • Int'l Joint Research
• [Presentation] 腹腔鏡下胃切除における3Dシュミュレーションとナビゲーション (2015)
  • Author(s): 西正暁,島田光生,吉川幸造,東島潤,徳永卓哉,中尾寿宏,髙須千絵,江藤祥平
  • Organizer: 第70回日本消化器外科学会総会
  • Place of Presentation: アクトシティ浜松(静岡県浜松市)
  • Year and Date: 2015-07-15
• [Presentation] LED光照射による癌幹細胞制御に関する研究 (2015)
  • Author(s): 西正暁,島田光生,吉川幸造,東島潤,中尾寿宏,徳永卓哉,柏原秀也,髙須千絵,江藤祥平
  • Organizer: 第24回日本癌病態治療研究会
  • Place of Presentation: 日光千姫物語(栃木県日光市)
  • Year and Date: 2015-06-25
• [Presentation] 膵癌細胞におけるResveratrolの autophagyを介した細胞増殖抑制効果 (2015)
  • Author(s): 西正暁,島田光生,吉川幸造,東島潤,中尾寿宏,徳永卓哉,髙須千絵,江藤祥平,寺奥大貴
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-04-16