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Development of the antimicrobial custom-made implant combined with antimicrobial iodine-supported process and CAOS technology

Research Project

Project/Area Number 15K19990
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKanazawa University

Principal Investigator

Kajino Yoshitomo  金沢大学, 附属病院, 特任准教授 (60622884)

Research Collaborator TSUCHIYA Hiroyuki  
KABATA Tamon  
TAKAHASHI Hiroyuki  
HASHIMOTO Yukinobu  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords抗菌加工 / カスタムメイドインプラント / コンピューター支援手術
Outline of Final Research Achievements

Iodine supported implant is the novel technology with a special oxide layer and countless micro pore. It holds both antimicrobial activity and osteoinductive activity. Three kinds of examinations were performed during this research period. Relationship between the surface roughness of the metal implant and antibacterial iodine-supported process, relationship between the change of the size of the metal implant and antibacterial iodine-supported process, and relationship between the sterilization process and the antibacterial iodine-supported process. These are important results for approval of the developed product.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2016 2015

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Journal Article] 3Dプリンター (付加製造技術)の医療への応用-現状と今後の課題-2016

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 井上大輔, 山本崇史, 高木知治, 大森隆昭, 土屋弘行
    • Journal Title

      関節外科

      Volume: 35 Pages: 112-116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 整形外科手術における3Dプリンターの臨床応用2016

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 井上大輔, 山本崇史, 高木知治, 大森隆昭, 土屋弘行
    • Journal Title

      日整会誌

      Volume: 90 Pages: 382-386

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The correlation between clinical radiological outcome and contact state of implant and femur using three-dimensional templating software in cementless total hip arthroplasty.2016

    • Author(s)
      Inoue D, Kabata T, Maeda T, Kajino Y, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H.
    • Journal Title

      Eur J Orthop Surg Traumatol

      Volume: 26 Issue: 6 Pages: 591-598

    • DOI

      10.1007/s00590-016-1796-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Periprosthetic Occult Fractures of the Acetabulum Occur Frequently During Primary THA.2016

    • Author(s)
      Hasegawa K, Kabata T, Kajino Y, Inoue D, Tsuchiya H.
    • Journal Title

      Clin Orthop Relat Res

      Volume: 475 Issue: 2 Pages: 484-494

    • DOI

      10.1007/s11999-016-5138-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safe zone for transacetabular screw fixation using a Kerboull cross-plate: A CT-scan templating prospective study.2016

    • Author(s)
      Ohmori T, Kabata T, Kajino Y, Hasegawa K, Inoue D, Tsuchiya H.
    • Journal Title

      Orthop Traumatol Surg Res

      Volume: 102 Issue: 8 Pages: 1017-1022

    • DOI

      10.1016/j.otsr.2016.09.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 股関節機能評価のための大腿骨座標系2015

    • Author(s)
      楫野良知,加畑多文,前田亨,長谷川和宏,井上大輔,山本崇史,土屋弘行
    • Journal Title

      関節外科

      Volume: 34 Pages: 142-148

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tapered wedge stem を用いた初回人工股関節全置換術-第一選択とする理由-2015

    • Author(s)
      楫野良知,加畑多文,前田亨,岩井信太郎,黒田一成,藤田健司,長谷川和宏,井上大輔,山本崇史,土屋弘行
    • Journal Title

      Hip Joint

      Volume: 41 Pages: 39-42

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tapered wedge stemを用いたcementless THAの利点と注意点2015

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 井上大輔,山本崇史, 高木知治, 大森隆昭, 土屋弘行
    • Journal Title

      Bone Joint Nerve

      Volume: 5 Pages: 733-739

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iodine-Supported Hip Implants: Short Term Clinical Results.2015

    • Author(s)
      Kabata T, Maeda T, Kajino Y, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H.
    • Journal Title

      Biomed Res Int.

      Volume: 2015 Pages: 1-6

    • DOI

      10.1155/2015/368124

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefullness of three-dimensional templating software to quantify the contact state between implant and femur in total hip arthroplasty.2015

    • Author(s)
      Inoue D, Kabata T, Maeda T, Kajino Y, Fujita K, Hasegawa K, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H.
    • Journal Title

      Eur J Orthop Surg Traumatol.

      Volume: 25 Issue: 8 Pages: 1293-1300

    • DOI

      10.1007/s00590-015-1705-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The value of bulk femoral head allograft in acetabular reconstruction using Kerboull-type plate.2015

    • Author(s)
      Inoue D, Kabata T, Maeda T, Kajino Y, Yamamoto T, Takagi T, Oomori T, Tsuchiya H.
    • Journal Title

      Int Orthop.

      Volume: 39 Issue: 9 Pages: 1839-1844

    • DOI

      10.1007/s00264-015-2857-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Value of computed tomography-based three-dimensional surgical preoperative planning software in total hip arthroplasty with developmental dysplasia of the hip.2015

    • Author(s)
      Inoue D, Kabata T, Maeda T, Kajino Y, Fujita K, Hasegawa K, Yamamoto T, Tsuchiya H.
    • Journal Title

      J Orthop Sci.

      Volume: 20 Issue: 2 Pages: 340-346

    • DOI

      10.1007/s00776-014-0683-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] インプラント表面加工の違いが抗菌ヨード担持加工に与える影響2016

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 多賀正, 長谷川和宏, 井上大輔, 山本崇史, 高木知治, 大森隆昭, 土屋弘行
    • Organizer
      日本整形外科基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Does the custom-made acetabular prosthesis reproduce a preoperative surgical planning? a cadaver study2016

    • Author(s)
      Kajino Y, Kabata T, Maeda T, Taga T, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H
    • Organizer
      29th International Society for Technology in Arthroplasty
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biological and biomechanical evaluation of iodine treated titanium implants2016

    • Author(s)
      Taga T, Kabata T, Kajino Y, Takagi T, Ohmori T, Tsuchiya H
    • Organizer
      29th International Society for Technology in Arthroplasty
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Cadaveric Validation Study of the Custom-Made Acetabular Prosthesis Produced by Additive Manufacturing2016

    • Author(s)
      Kajino Y, Kabata T, Maeda T, Hasegawa K, Inoue D, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H
    • Organizer
      16th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2016-06-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Iodine-supported titanium implants inhibit biofilm formation and growth2016

    • Author(s)
      Inoue D, Kabata T, Maeda T, Kajino Y, Hasegawa K, Yamamoto T, Takagi T, Ohmori T, Tsuchiya H
    • Organizer
      17th European Federation of National Associations of Orthopaedics and Traumatology
    • Place of Presentation
      Geneve, Switzerland
    • Year and Date
      2016-06-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 人工股関節再置換術用カップにおけるプレートおよびフランジにかかる応力分布2015

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 井上大輔, 山本崇史, 高木知治, 大森隆昭, 土屋弘行, 高橋広幸, 中川誠治
    • Organizer
      第42回 日本股関節学会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 線維性骨異形成にともなうShepherd’s crook deformityの3例2015

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 井上大輔, 山本崇史, 高木知治, 大森隆昭, 土屋弘行
    • Organizer
      第20回 日本運動器再建・イリザロフ法研究会
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] A Novel Device For Measuring The Orientation Of The Femoral Component In Total Hip Arthroplasty2015

    • Author(s)
      Yoshitomo Kajino, Tamon Kabata, Toru Maeda, Kazuhiro Hasegawa, Daisuke Inoue, Takashi Yamamoto, Tomoharu Takagi, Hiroyuki Tsuchiya
    • Organizer
      16th European Federation of National Associations of Orthopaedics and Traumatology (EFORT)
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 整形外科手術における3Dプリンターの臨床応用2015

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 長谷川和宏, 井上大輔, 山本崇史, 高木知治, 土屋弘行
    • Organizer
      第88回 日本整形外科学会学術総会
    • Place of Presentation
      神戸国際会議場ほか(兵庫県神戸市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Screw併用press-fit cementless cupの初期固定に必要な骨性被覆量の限界と臨床経過2015

    • Author(s)
      楫野良知, 加畑多文, 前田亨, 長谷川和宏, 井上大輔, 山本崇史, 高木知治, 土屋弘行
    • Organizer
      第88回 日本整形外科学会学術総会
    • Place of Presentation
      神戸国際会議場ほか(兵庫県神戸市)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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