| Project/Area Number |
15K20184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Omura Go 東京大学, 医学部附属病院, 登録研究員 (00601139)
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| Research Collaborator |
ANDO Mizuo 東京大学, 医学部附属病院, 講師
YOSHIDA Masafumi 東京大学, 医学部附属病院, 講師
SAITO Yuki 東京大学, 医学部附属病院, 助教
ASAKAGE Takahiro 東京医科歯科大学, 医学部附属病院, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | FAK / 下咽頭癌 / TP53変異 / TP53 / ALDH2 / HPV / Focal Adhesion Kinase / 手術療法 / 予後 |
|---|
| Outline of Final Research Achievements |
We demonstrated that ① upregulated expression of focal adhesion kinase (FAK) had a significant impact on prognosis, the number of metastatic LNs, and the incidence of distant metastases in surgically treated hypopharyngeal squamous cell carcinoma (HPSCC) patients, ② not HPV, but ALDH2 polymorphism and alcohol behavior correlated with the carcinogenesis of HPSCC, ③ TP53 mutations had a significant impact on prognosis, in surgically treated HPSCC patients. In contrast, FAK does not correlated with TP53 and PIK3CA mutations,
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