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Ppp6c-deficiency and cancer predisposition

Research Project

Project/Area Number 15K20237
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

MOMOI Yuki  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 共同研究員 (10750440)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔咽頭科学
Outline of Final Research Achievements

Several experiment using biochemical experiments have suggested that protein phosphatase 6 (PP6) functions at cell cycle check point, suppresses NFkB signaling, and also functions in DNA repair. However, whether PP6 is involved in carcinogenesis has not been examined. We previously reported that deficiency in the gene encoding the catalytic subunit of protein phosphatase 6 (Ppp6c) predisposes mouse skin tissue to papilloma formation initiated by DMBA. Then, we demonstrated that Ppp6c loss acts as a tumor promoter in UVB-induced basal cell carcinogenesis. Importantly, somatic mutations in Ppp6c gene have been identified in approximately 10% of malignant melanoma patients harboring Braf or Nras mutations. In this experiment, we found that induction of double mutation (Ppp6c deficiency and KrasG12D expression) in the cytokeratin 14 positive cells drives cell proliferation, and leaded to hyperplasia of squamous epithelium tissue.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.2016

    • Author(s)
      Ogoh, H., Tanuma, N., Matsui, Y., Hayakawa, N., Inagaki, A., Sumiyoshi, M., Momoi, Y., Kishimoto, A., Suzuki, M., Sasaki, N., Ohuchi, T., Nomura, M., Teruya, Y., Yasuda, K., Watanabe, T., Shima, H.
    • Journal Title

      Mechanisms of Development

      Volume: 139 Pages: 1-9

    • DOI

      10.1016/j.mod.2016.02.001

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA2015

    • Author(s)
      Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
    • Journal Title

      Oncogene

      Volume: 印刷中 Issue: 35 Pages: 4647-55

    • DOI

      10.1038/onc.2014.398

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.2015

    • Author(s)
      Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H.
    • Journal Title

      Cancer Lett.

      Volume: 365 Issue: 2 Pages: 223-228

    • DOI

      10.1016/j.canlet.2015.05.022

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 発がんプロモーターオカダ酸の標的、PP6の皮膚がん抑制遺伝子としての意義2016

    • Author(s)
      島礼、黒沢是之、小河穂波、桃井勇貴、井上維、田沼延公、渡邊利雄
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      宮城県・仙台市
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脱リン酸化酵素PP6は、皮膚がん抑制遺伝子である2016

    • Author(s)
      黒沢是之、桃井勇貴、井上唯、小河穂波、後藤孝浩、田沼延公、渡邊利雄、島礼
    • Organizer
      第7回 プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      自然科学研究機構(愛知県、岡崎市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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