| Project/Area Number |
15K20312
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Research Collaborator |
HORIKAWA Hidemasa
MISAWA Shigeo
TSUDA Tatsuya
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 遊離脂肪移植 / HGF遺伝子プラスミド / ＨＧＦ遺伝子プラスミド |
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| Outline of Final Research Achievements |
As a basic research on gene therapy using HGF gene plasmid in free adipose tissue transplantation, an experiment was conducted in an animal model. As a result, there was no significant difference in atrophy rate of transplanted free fat at 3 months after transplantation. However, qualitative evaluation by immunostaining revealed that it inhibited the necrosis of adipocytes in the HGF gene plasmid introduced group. Further verification such as genetic analysis and protein analysis is necessary in the future, but suppression of necrosis of transplanted fat clinically can lead to the prevention of cyst formation and calcification known as late complications, I believe that clinical application can be expected especially in fat injection technique in breast.
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