| Project/Area Number |
15K20361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Tabata Atsushi 徳島大学, 大学院生物資源産業学研究部, 講師 (10432767)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ストレプトリジンS / 口腔連鎖球菌 / アンギノーサス群連鎖球菌 / 病原因子 / Streptococcus |
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| Outline of Final Research Achievements |
This study was conducted to reveal the detailed cytotoxic mechanism caused by the action of streptolysin S (SLS) homolog, a peptide hemolysin secreted from Streptococcus anginosus subsp. anginosus (SAA) normally habitual in the human oral cavity. As first, an in vitro preparation system for the recombinant SLS homolog was investigated to prepare the assay tool for the investigation of the cytotoxicity specifically induced by SLS homolog. In addition, the exhaustive gene expression analysis of the human cell line co-cultured with SLS homolog secreting β-hemolytic SAA was conducted and showed some interesting variation of the gene expression profile induced by the action of SLS homolog. From this study, we get on base of the elucidation about the cytotoxic mechanism of SLS homolog secreted from β-hemolytic SAA strain.
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