Proteomic analysis of cell competition in the lateral invasion front of oral squamous cell carcinoma
Project/Area Number |
15K20384
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Niigata University |
Principal Investigator |
ABE Tatsuya 新潟大学, 医歯学総合研究科, 特任助教 (70634856)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 口腔扁平上皮癌 / 細胞競合 / プロテオミクス / 扁平上皮癌 / 癌‐非癌界面 / ladinin-1 / actin / 口腔上皮内癌 / 免疫組織化学 |
Outline of Final Research Achievements |
Oral squamous cell carcinoma (SCC) and carcinoma in-situ (CIS) frequently form the interface facing non-cancerous epithelium. I hypothesized cell competition might be occurred between cancer and non-cancerous cells in this interface. Thus, I investigated this interface histopathologically and performed proteomic analysis using LC-MS/MS. In histological analysis, apoptotic bodies, hyaline bodies, and other morphological changes suggesting cell damage were frequently observed in the cancer side adjacent to the interface. From proteomic analysis, 7 proteins, specifically increasing or decreasing in the cancer or non-cancerous sides adjacent to the interface, were identified. These proteins may be involved in cell competition between oral SCC/CIS cells and non-cancerous cells.
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Report
(4 results)
Research Products
(11 results)