Educidation of the innate immune response of odontoblasts against bacteria-derived factor in the pathogenesis of pulpitis
| Project/Area Number |
15K20406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯髄炎 / 象牙芽細胞 / 自然免疫 / インターフェロンγ / KN-3 細胞 |
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| Outline of Final Research Achievements |
In the progression of pulpitis, marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed. Odontoblasts located in the outermost layer of dental pulp first recognize caries-related pathogens, and have a capacity to produce various pro-inflammatory cytokines in response to microbial pattern recognition receptors.
This study demonstrated the synergistic effects of IFN-γ on cytokine production in KN-3 cells stimulated with bacteria-derived factors. These findings suggest that IFN-γ may modulate the innate immune response in odontoblasts.
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Report
(3 results)
Research Products
(8 results)
