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Research of genetic analysis and prevention for cleft lip and/or cleft palate in Lao People's Democratic Republic

Research Project

Project/Area Number 15K20549
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TAKAHIRO GOTO  琉球大学, 医学部附属病院, 助教 (60578912)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口唇口蓋裂 / ラオス人民民主共和国 / 遺伝子 / 予防 / 分子遺伝学 / 発生予防
Outline of Final Research Achievements

We have engaged in activities such as free-of-charge surgery for CL/P a total of 3 times from 2015 to 2017 in Lao People’s Democratic Republic (Laos), and we have performed CL/P-related surgeries for 55 patients. About 50 patients among 55 who performed surgery were provided their blood samples. About 50 patients who excluded surgery by low weight and age, cold but gained consensus were also provided their blood samples. We arranged our equipments raised skills of diagnosis and surgey by KAKENHI. Many studies reported CL/P related genes were different between cleft types. Our gene samples were highly reliable because we visited Laos and the details of cleft types were diagnosed only by us. We have prepared for analyzing on CL/P related genes for Laotian people using Taqman genotyping assay.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(9 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Outcomes of an international volunteer surgical project for patients with cleft lip and/or cleft palate: A mission in developing Laos2017

    • Author(s)
      Goto Takahiro、Nishihara Kazuhide、Kataoka Keiichi、Goto Shinpei、Maruyama Tessho、Sunakawa Hajime、Natsume Nagato、Arasaki Akira
    • Journal Title

      Congenit Anom

      Volume: 不明 Issue: 4 Pages: 112-116

    • DOI

      10.1111/cga.12255

    • ISSN
      0914-3505
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topographic Analysis of the maxillary premolars relative to the maxillary sinus and the alveolar bone using cone-beam computed tomography2017

    • Author(s)
      Kazuhide Nishihatra, Shinichiro Yoshimine, Takahiro Goto, et al
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radialogy

      Volume: 123 Pages: 606-612

    • DOI

      10.1016/j.oooo.2017.01.007

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kikuchi-Fujimoto disease in the regional lymph nodes with node metastasis in a patient with tongue cancer: A case report and literature review2017

    • Author(s)
      Maruyama Tessho、Nishihara Kazuhide、Saio Masanao、Nakasone Toshiyuki、Nimura Fumikazu、Matayoshi Akira、Goto Takahiro、Yoshimi Naoki、Arasaki Akira
    • Journal Title

      Oncol Lett

      Volume: 14 Pages: 257-263

    • DOI

      10.3892/ol.2017.6139

    • NAID

      120006847270

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benign epithelial inclusion consisting of squamous metaplasia and small glandular elements in regional lymph node of a patient with tongue cancer: a case report and literature review2016

    • Author(s)
      Maruyama T, Nakasone T, Saio M, Nishihara K, Matayoshi A, Goto T, et al
    • Journal Title

      International Journal of Clinical and Experimental Pathology

      Volume: 9 Pages: 4027-4032

    • NAID

      120006845624

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日本口腔ケア学会誌(1巻~9巻)における掲載論文の分析と今後の検討について2016

    • Author(s)
      後藤尊広, 西原一秀, 知花ゆき子, 外間妃奈, 濱川恵理子, 源河里美, 新崎 章
    • Journal Title

      日本口腔ケア学会誌

      Volume: 10 Pages: 178-180

    • NAID

      40021046006

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 小下顎症を伴った口蓋裂患者の口蓋形成術時に他診療科との綿密な連携を図った2例2017

    • Author(s)
      後藤尊広, 西原一秀, 仁村文和, 又吉 亮, 河野俊広, 仲宗根敏幸, 片岡恵一, 加藤大貴,萩原 泉, 丸山修幸, 村橋佳代子, 光安皓平, 後藤新平, 新崎 章
    • Organizer
      第34回日本障害者歯科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当科の最近10年間の口唇裂・口蓋裂患者における合併先天異常に関する臨床統計的観察2016

    • Author(s)
      後藤尊広, 西原一秀, 牧志祥子, 片岡恵一, 島袋亜香里, 後藤新平, 新崎 章
    • Organizer
      第40回日本口蓋裂学会.
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター(大阪府北区)
    • Year and Date
      2016-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 当科の最近10年間の口唇裂・口蓋裂患者における合併先天異常に関する臨床統計的観察2016

    • Author(s)
      後藤尊広, 西原一秀, 牧志祥子, 片岡恵一, 島袋亜香里, 後藤新平, 新崎 章
    • Organizer
      第40回日本口蓋裂学会
    • Place of Presentation
      ナレッジキャピタル コングレコンベンションセンター(大阪府、大阪市、北区、深町)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 当科におけるラオス人民民主共和国での口唇口蓋裂無償手術活動について2015

    • Author(s)
      後藤尊広, 西原一秀, 牧志祥子, 片岡恵一, 島袋亜香里, 夏目長門, 砂川 元, 新崎 章
    • Organizer
      第39回日本口蓋裂学会.
    • Place of Presentation
      シェーンバッハサボー(砂防会館)(東京都千代田区)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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