Periodontal pathogenic infection of risk factor of myocardial hypertrophy

• Project/Area Number: 15K20616
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yoshida Asuka 東京医科歯科大学, 歯学部附属病院, 医員 (30749487)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周病

Outline of Final Research Achievements

Recently, it's reported that periodontitis is possibility of risk factor of cardiovascular diseases. We revealed that pressure overload induced cardiac hypertrophy, intercellular fibrosis and perivascular fibrosis are accelerated by infection of periodontal pathogen. The purpose of this study was to reveal how to affect infection of periodontal pathogen to cardiac hypertrophy. It's revealed that infection of the other periodontal pathogen deteriorate cardiac hypertrophy and through the protein receptor there was on the cell surface, intercellular fibrosis and expression of inflammation marker were suppressed

Research Products

• [Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice. (2017)
  • Author(s): Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y.
  • Journal Title: Hypertens Res Volume: 40 Issue: 2 Pages: 35-40
  • DOI: 10.1038/hr.2016.117
  • Peer Reviewed
• [Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice (2017)
  • Author(s): Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y
  • Journal Title: Hypertens Res. Volume: 40 Issue: 1 Pages: 35-40
  • DOI: 10.1038/hr.2016.114
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Periodontitis and myocardial hypertrophy (2017)
  • Author(s): Suzuki J, Sato H, Kaneko M, Yoshida A, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, IzumiY, Isobe M, Komuro I
  • Journal Title: Hypertens Res Volume: [Epub ahead of print] Issue: 4 Pages: 324-328
  • DOI: 10.1038/hr.2016.146
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 音波歯ブラシを用いた歯間隣接面におけるプラーク除去率の検討 (2015)
  • Author(s): 吉田明日香, 青山典生, 小川実穂, 和泉雄一
  • Organizer: 第８０回口腔病学会記念学術大会
  • Place of Presentation: 鈴木章夫記念講堂（東京 御茶ノ水）
  • Year and Date: 2015-12-26
• [Presentation] 侵襲性歯周炎における治療効果予知マーカーとしての細菌検査の有用性 (2015)
  • Author(s): 竹内康雄，片桐さやか，小林宏明，駒崎利奈，須田智也，若松美江，高松秀行，早雲彩絵，高野琢也，楠侑香子，吉田明日香，杵渕恵那，大津杏理，関内孝侑，片山沙織，中里昭仁，三瀬太記，和泉雄一
  • Organizer: 第142回日本歯科保存学会春季学術大会
  • Place of Presentation: 北九州国際会議場、西日本総合展示場（福岡 北九州）
  • Year and Date: 2015-06-25
• [Presentation] 冠動脈疾患患者での歯周病罹患状態の解析 (2015)
  • Author(s): 青山典生，鈴木淳一，小林奈穂，吉田明日香，金子誠，始平堂由佳，佐藤博紀，磯部光章，和泉雄一
  • Organizer: 第58回春季日本歯周病学会学術大会
  • Place of Presentation: 幕張メッセ（千葉 幕張）
  • Year and Date: 2015-05-16