Development of niucleic delivery system for targeting primary and metametastatic tumor
| Project/Area Number |
15K20831
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
SATO Yusuke 北海道大学, 薬学研究院, 助教 (10735624)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂質ナノ粒子 / 核酸送達 / 粒子径 / がん浸透性 / 動態制御 / siRNA / 薬物送達 / 粒径 |
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| Outline of Final Research Achievements |
Limitation of diffusion of lipid nanoparticles (LNP) in tumor tissues is a severe problem for development of tumor-targeted short interfering RNA (siRNA) delivery system. In this research, to solve the problem, I developed a technology for controlling LNP size and elucidated the cause for a reduced efficiency of siRNA delivery, which is accompanied by downsizing of the siRNA-loaded LNPs.
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Report
(3 results)
Research Products
(13 results)
