Study of the mechanism of electrophile signaling regulation by reactive persulfide species
Project/Area Number |
15K20855
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General physiology
General pharmacology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 活性イオウ分子 / 親電子シグナル制御 / 酸化ストレス / 8-ニトロ-cGMP / メチル水銀 / 新電子シグナル / 活性イオウ分子種 / 活性酸素 / 神経細胞 |
Outline of Final Research Achievements |
We investigated the mechanism of neurotoxicity induced by environmental electrophile methylmercury focusing on the signal regulatory function of reactive persulfide species. We found that methylmercury exposure to cells induced depletion of intracellular reactive persulfides and subsequently evoked abnormal activation of signaling pathway mediated by endogenous signaling molecule 8-nitro-cGMP to cause neuronal death. The results of this study will contribute to the elucidation of the mechanism of toxic effect by environmental chemicals and physiological function of reactive persulfide species.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 12016
Author(s)
Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.
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Journal Title
Biochem Biophys Res Commun
Volume: 480
Issue: 2
Pages: 180-186
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP252015
Author(s)
K. Kunieda, H. Tsutsuki, T. Ida, Y. Kishimoto, S. Kasamatsu, T. Sawa, N. Goshima, M. Itakura, M. Takahashi, T. Akaike, H. Ihara
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Journal Title
ACS Chemical Neuroscience
Volume: 6
Issue: 10
Pages: 1715-1725
DOI
Related Report
Peer Reviewed / Open Access
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