Screening of ECM-selective peptide for Small-diameter artificial blood vessels
Project/Area Number |
15K21070
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biofunction/Bioprocess
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Nagoya University |
Principal Investigator |
Kanie Kei 名古屋大学, 創薬科学研究科, 助教 (80636407)
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Research Collaborator |
KATO Ryuji 名古屋大学, 大学院創薬科学研究科, 准教授
EBARA Mitsuhiro 物質・材料研究機構, MANAナノシステム分野, MANA准主任研究者
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | ペプチド / 人工血管 / バイオマテリアル / 内皮細胞 / 高分子材料 / コラーゲンIV / 間葉系幹細胞 / 骨再生 / 細胞外マトリックス / 細胞接着 / サイトカイン / 骨分化 / 平滑筋細胞 |
Outline of Final Research Achievements |
Aim of this study is obtaining short selective-peptides for enhancing the effect of artificial blood vessel. There are two detail aims, one is screening ECM-selective adhesion peptides, and another is screening endotherial cell(EC)-selective adhesion peptides. As a result, some Collagen IV-selective peptides and EC-selective peptides were successfully obtained in this two years. Additionally, combination of peptide and polymeric materials could control the EC-selectivity.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-Selective Adhesion2016
Author(s)
Rio Kurimoto, Kei Kanie, Naokazu Idota, Mitsuo Hara, Shusaku Nagano, Takehiko Tsukahara, Yuji Narita, Hiroyuki Honda, Masanobu Naito, Mitsuhiro Ebara, Ryuji Kato
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Journal Title
International Journal of Polymer Science
Volume: 2016
Pages: 2090985-2090985
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combinational Effects of Polymer Viscoelasticity and Immobilized Peptides on Cell Adhesion to Cell-selective Scaffolds2016
Author(s)
Rio KURIMOTO, Kei KANIE, Koichiro UTO, Shun KAWAI, Mitsuo HARA, Shusaku NAGANO, Yuji NARITA, Hiroyuki HONDA, Masanobu NAITO, Mitsuhiro EBARA, Ryuji KATO
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Journal Title
Analytical Sciences
Volume: 32
Issue: 11
Pages: 1195-1202
DOI
NAID
ISSN
0910-6340, 1348-2246
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] メカノバイオロジーにおける流動性材料と機能性生体分子の組み合わせによる細胞選択的な接着性制御の検討2017
Author(s)
栗本理央, 蟹江慧, 宇都甲一郎, 河合駿, 原光生, 永野修作, 成田裕司, 本多裕之, 内藤昌信, 荏原充宏, 加藤竜司
Organizer
第16回日本再生医療学会総会
Place of Presentation
仙台国際センター
Year and Date
2017-03-08
Related Report
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[Presentation] Combinational Effects of Viscoelasticity of Substrate and the Immobilized Peptides on Selective Cell Adhesion2016
Author(s)
Rio Kurimoto, Kei Kanie, Koichiro Uto, Shun kawai, Mitsuo Hara, Shusaku Nagano, Yuji Narita, Hiroyuki Honda, Mas-anobu Naito, Ryuji Kato and Mitsuhiro Ebara
Organizer
2nd International Symposium on Nanoarchitectnics for Mechanobiology
Place of Presentation
MANA, NIMS, Japan
Year and Date
2016-07-27
Related Report
Int'l Joint Research
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[Presentation] 合成高分子と短鎖ペプチドとの組み合わせ効果を用いた細胞選択的材料表面の設計2016
Author(s)
栗本理央, 蟹江慧, 宇都甲一郎, 河合駿, 原光生, 永野修作, 成田裕司, 加藤竜司, 内藤昌信, 荏原充宏
Organizer
日本生物工学若手研究者の集い 夏のセミナー2016
Place of Presentation
ホテルコンチネンタル府中, 東京
Year and Date
2016-07-16
Related Report
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