Pathogenicity of Avian Infuenza Virus Isolates in Vietnam to domestic ducks

• Project/Area Number: 15K21168
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science; Animal production science
• Research Institution: Tottori University
• Principal Investigator: SODA Kosuke 鳥取大学, 農学部, 講師 (00582983)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 鳥インフルエンザ / アヒル / 病原性 / 重感染 / ベトナム / 日本

Outline of Final Research Achievements

Highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza virus (LPAIV) have been co-circulating in domestic poultry populations in Vietnam. In the present study, we examined whether pathogenicity of HPAIV was affected by co-infection with LPAIV. Upon result, HPAIV showed reduced pathogenicity in domestic ducks with prior infection of LPAIV. Cross-antigenicity between inoculated viruses and/or innate immunity induced by prior LPAIV infection might be involved in the phenomenon.

Academic Significance and Societal Importance of the Research Achievements

高病原性鳥インフルエンザウイルス(HPAIV)と並行して低病原性鳥インフルエンザウイルス(LPAIV)が家禽で流行している国が、アジア各国を中心に認められている。本研究により、HPAIVによる症状の顕在化がLPAIVの流行により抑えられ、HPAIVが浸潤している家禽群の同定を困難にしていることが示された。HPAIVの排除には、LPAIVのコントロールも併せて必要であると考えられ、本成果は今後の鳥インフルエンザ対策において有効な手段を講じていく上で強力な科学的根拠となる。

Research Products

• [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)
• [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)
• [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)
• [Int'l Joint Research] ベトナム国立衛生疫学研究所(NIHE)(ベトナム)
• [Journal Article] Characterization of Highly Pathogenic Avian Influenza Virus A(H5N6), Japan, November 2016. (2017)
  • Author(s): (8)Okamatsu, M., Ozawa, M., Soda, K., Takakuwa, H., Haga, A., Hiono, T., Matsuu, A., Uchida, Y., Iwata, R., Matsuno, K., Kuwahara, M., Yabuta, T., Usui, T., Ito, H., Onuma, M., Sakoda, Y., Saito, T., Otsuki, K., Ito, T., Kida, H.
  • Journal Title: Emerging Infectious Diseases Volume: 23(4) Issue: 4 Pages: 691-695
  • DOI: 10.3201/eid2304.161957
  • NAID: 120006337764
  • Peer Reviewed / Open Access
• [Journal Article] Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016/2017 (2017)
  • Author(s): Nobuhiro Takemae、Ryota Tsunekuni、Kirill Sharshov、Taichiro Tanikawa、Yuko Uchida、Hiroshi Ito、Kosuke Soda、Tatsufumi Usui、Ivan Sobolev、Alexander Shestopalov、Tsuyoshi Yamaguchi、Junki Mine、Toshihiro Ito、Takehiko Saito
  • Journal Title: Virology Volume: 512 Pages: 8-20
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] ベトナムの家禽由来H5亜型高病原性鳥インフルエンザウイルスに対する抗体保有状況 (2018)
  • Author(s): 永菅麻依子、曽田公輔、仲村 望、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、Le Quynh Mai、伊藤壽啓
  • Organizer: 第161回日本獣医学会学術集会
• [Presentation] ベトナムの家禽から分離されたclade2.3.4.4 H5亜型高病原性鳥インフルエンザウイルスのアヒルに対する病原性 (2018)
  • Author(s): 曽田公輔、山根真弥、伊藤啓史、伊藤壽啓
  • Organizer: 第161回日本獣医学会学術集会
• [Presentation] Clade 2.3.4.4 H5 highly pathogenic avian influenza viruses showed various pathogenicity in domestic ducks (2018)
  • Author(s): Kosuke Soda, Maya Yamane, Hiroshi Ito, Toshihiro Ito
  • Organizer: The 66th annual meeting of the Japanese Society for Virology
• [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam (2017)
  • Author(s): Kosuke Soda, Nguyen Le Khanh Hang, Ung Thi Hong Trang, Hiroshi Ito, Le Thi Quynh Mai, Toshihiro Ito
  • Organizer: International Symposium in Veterinary Science Strengthening the Collaboration between Indonesia and Japanese Veterinary School
  • Place of Presentation: Bogor, Indonesia
  • Year and Date: 2017-01-19
  • Int'l Joint Research
• [Presentation] ベトナムの家禽から分離されたH3亜型インフルエンザウイルスの遺伝子と抗原性の解析 (2017)
  • Author(s): 柏原美奈、曽田公輔、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、高桑弘樹、Le Quynh Mai、伊藤壽啓
  • Organizer: 第32回中国四国ウイルス研究会
• [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam (2017)
  • Author(s): Kosuke Soda, Ung Thi Hong Trang, Nguyen Le Khanh Hang, Tatsufumi Usui, Hiroshi Ito, Hiroichi Ozaki, Tsuyoshi Yamaguchi, Le The Quynh Mai, Toshihiro Ito
  • Organizer: International Union of Microbiological Societies Congresses 2017
  • Int'l Joint Research
• [Presentation] 2016-17シーズンに国内の野鳥糞便および斃死体から分離されたH5N6亜型高病原性鳥インフルエンザウイルスの性状解析 (2017)
  • Author(s): 曽田公輔、伊藤啓史、笛吹達史、尾崎弘一、村瀬敏之、山口剛士
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] ベトナムの家禽から分離されたH3亜型インフルエンザウイルスの遺伝子と抗原性の解析 (2017)
  • Author(s): 柏原美奈、曽田公輔、Ung Hong Trang、Nguyen Khanh Hang、伊藤啓史、高桑弘樹、Le Quynh Mai、伊藤壽啓
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and zoo animals in Japan in 2016-17 (2017)
  • Author(s): Kosuke Soda, Tatsufumi Usui, Hiroshi Ito, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Toshihiro Ito
  • Organizer: The 65th annual meeting of the Japanese Society for Virology
• [Presentation] Serological Surveillance of Highly Pathogenic Avian Influenza in Domestic Poultry in Vietnam (2016)
  • Author(s): Nozomi Nakamura, ○Kosuke Soda, Ung Hong Trang, Nguyen Le Khanh Hang, Hiroshi Ito, Le Thi Quynh Mai, Toshihiro Ito
  • Organizer: The 64th annual meeting of the Japanese Society for Virology
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2016-10-23
• [Presentation] ベトナムの家禽におけるH5亜型高病原性鳥インフルエンザウイルス流行株の変化 (2016)
  • Author(s): 曽田公輔、Ung Thi Hong Trang、Le Khanh Hang Nguyen、伊藤啓史、Le The Quynh Mai、伊藤壽啓
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 神奈川県藤沢市
  • Year and Date: 2016-09-06
• [Presentation] ベトナムの家禽のH5亜型高病原性鳥インフルエンザウイルス(HPAIV)に対する抗体保有状況 (2016)
  • Author(s): 仲村 望、曽田公輔、Ung Thi Hong Trang、Le Khanh Hang Nguyen、伊藤啓史、Le The Quynh Mai、伊藤壽啓
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 神奈川県藤沢市
  • Year and Date: 2016-09-06
• [Presentation] Antigenic and genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated in Japan and Vietnam (2016)
  • Author(s): Kosuke Soda, Ung Thi Hong Trang, Kozue Hotta, Le Thi Quynh Mai, Tetsu Yamashiro, Toshihiro Ito
  • Organizer: Options IX for the Control of Influenza
  • Place of Presentation: Chicago, U.S.
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] Antigenic and Genetic analyses of novel clade 2.3.4.4 H5 highly pathogenic avian influenza viruses (2015)
  • Author(s): Kosuke Soda, Kozue Hotta, Ung Hong Trang, Susumu Toyoumi, Yukiko Uno, Yasuko Nagai, Tatsufumi Usui, Le Quynh Mai, Yukiko Tomioka, Hiroshi Ito, Hiroichi Ozaki, Toshiyuki Murase, Tsuyoshi Yamaguchi, Tetsu Yamashiro, Toshihiro Ito
  • Organizer: The 63rd annual meeting of the Japanese Society for Virology
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] ベトナムのアヒルから新たに分離されたclade2.3.4.4 H5亜型高病原性鳥インフルエンザウイルスの遺伝子と抗原性 (2015)
  • Author(s): 曽田公輔、Ung Hong Trang、堀田こずえ、豐海 晋、宇野有紀子、永井泰子、Le Quynh Mai、富岡幸子、尾崎弘一、伊藤啓史、山城 哲、伊藤壽啓
  • Organizer: 第158回日本獣医学会学術集会
  • Place of Presentation: 十和田、青森
  • Year and Date: 2015-09-07
• [Presentation] Antigenic and genetic variation of H5 highly pathogenic avian influenza viruses in domestic ducks in Vietnam (2015)
  • Author(s): Kosuke Soda, Kozue Hotta, Ung T. H. Trang, Susumu Toyoumi, Yukiko Uno, Yasuko Nagai, Tatsufumi Usui, Le T.Q. Mai, Hiroichi Ozaki, Hiroshi Ito, Hiroki Takakuwa, Toshiyuki Murase, Tsuyoshi Yamaguchi, Etsuro Ono, Koichi Otsuki, Tetsu Yamashiro, Toshihiro Ito
  • Organizer: 16th Negative Strand Virus Meeting
  • Place of Presentation: Siena, Italy
  • Year and Date: 2015-06-14
  • Int'l Joint Research