| Project/Area Number |
15K21201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
Endocrinology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YOSHIDA Sumiko 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (40510904)
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| Research Collaborator |
AIHARA Ken-ichi
WALSH Kenneth
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓リモデリング / INSL6 / アンジオテンシンII / ＩＮＳＬ６ / アンジオテンシンＩＩ |
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| Outline of Final Research Achievements |
We examined the role of INSL6 in the heart using INSL6 deficient mice (INSL6 KO). There was no difference in cardiac morphology between INSL6 KO mice and wild type mice under normal condition. INSL6 KO mice after angiotensin II stimulation showed significantly increased myocardial fibrosis and decreased cardiac function compared with wild type mice. It was suggested that INSL6 is involved in myocardial fibrosis and cardiac remodeling.
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