Role of cardiac remodeling of novel peptide hormone INSL6

• Project/Area Number: 15K21201
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine; Endocrinology
• Research Institution: The University of Tokushima
• Principal Investigator: YOSHIDA Sumiko 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (40510904)
• Research Collaborator: AIHARA Ken-ichi ; WALSH Kenneth
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心臓リモデリング / INSL6 / アンジオテンシンII / ＩＮＳＬ６ / アンジオテンシンＩＩ

Outline of Final Research Achievements

We examined the role of INSL6 in the heart using INSL6 deficient mice (INSL6 KO). There was no difference in cardiac morphology between INSL6 KO mice and wild type mice under normal condition. INSL6 KO mice after angiotensin II stimulation showed significantly increased myocardial fibrosis and decreased cardiac function compared with wild type mice. It was suggested that INSL6 is involved in myocardial fibrosis and cardiac remodeling.

Research Products

• [Journal Article] Remarkable shrinkage of a GH-secreting macroadenoma induced by somatostatin analogue administration; a case report and a literature review. (2017)
  • Author(s): Kurahashi K, Endo I, Kondo T, Morimoto K, Yoshida S, Kuroda A, Aihara K, Matsuhisa M, Nakajima K, Mizobuchi Y, Nagahiro S, Abe M, Fukumoto S
  • Journal Title: Inter Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Suppression of the Hypothalamic-Pituitary-Adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer. (2016)
  • Author(s): Kondo T, Endo I, Ooguro Y, Morimoto K, Kurahashi K, Yoshida S, Kuroda K, Aihara K, Matsuhisa M, Abe M, Fukumoto S
  • Journal Title: Inter Med Volume: 55 Issue: 24 Pages: 3623-3626
  • DOI: 10.2169/internalmedicine.55.7359
  • NAID: 130005250355
  • Peer Reviewed
• [Journal Article] Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors (2016)
  • Author(s): Kondo T, Endo I, Aihara K, Onishi Y, Dong B, Ohguro Y, Kurahashi K, Yoshida S, Fujinaka Y, Kuroda A, Matsuhisa M, Fukumoto S, Matsumoto T, Abe M.
  • Journal Title: Endocrine Journal Volume: 63 Issue: 4 Pages: 397-404
  • DOI: 10.1507/endocrj.EJ15-0589
  • NAID: 130005146452
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Roles of the Androgen – Androgen Receptor System in Vascular Angiogenesis (2016)
  • Author(s): Sumiko Yoshida, Yasumasa Ikeda and Ken-ichi Aihara
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 3 Pages: 257-265
  • DOI: 10.5551/jat.31047
  • NAID: 130005131882
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Presentation] Inslin-like peptide 6はアンジオテンシンII刺激による心筋線維化を抑制する (2016)
  • Author(s): 吉田守美子
  • Organizer: 第34回内分泌代謝学サマーセミナー
  • Place of Presentation: 久山温泉 ホテル夢家（福岡県糟屋郡久山町）
• [Presentation] Inslin-like peptide 6はアンジオテンシンII負荷による心筋線維化に関与する (2015)
  • Author(s): 吉田守美子、粟飯原賢一、Kenneth Walsh
  • Organizer: 第38回 日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-09
• [Book] 臨床雑誌 内科 特集 症候から考える画像診断アトラス 薬を飲んでも血圧が下がりません (2017)
  • Author(s): 吉田守美子、福本誠二
  • Total Pages: 883
  • Publisher: 南江堂