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Development of a novel diagnosis marker for kidney diseases by metabolome analysis

Research Project

Project/Area Number 15K21364
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
General physiology
Research InstitutionKeio University

Principal Investigator

HIRAYAMA Akiyoshi  慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (00572405)

Research Collaborator MARUYAMA Shoichi  
AKIYAMA Shinichi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords腎疾患 / マーカー / CE-MS / 尿 / 血漿 / ネフローゼ / メタボロミクス / バイオマーカー
Outline of Final Research Achievements

In this study, a comprehensive analysis of urine and plasma metabolites from nephrotic disease patients was conducted by capillary electrophoresis-mass spectrometry (CE-MS) in order to discover biomarkers specific to the type of disease. As a result, it was possible to create a model to distinguish from seven types of nephrotic diseases by combining two to five types of metabolites. With respect to unknown peaks, it was possible to perform a fractionation operation using LC-MS to identify new biomarker candidates.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration2018

    • Author(s)
      Y Saito, Y Morine, S Iwahashi, T Ikemoto, S Imura, H Yamanaka-Okumura, A Hirayama, T Soga, M Tomita, M Shimada
    • Journal Title

      Ann Gastroenterol Surg

      Volume: - Issue: 3 Pages: 1-8

    • DOI

      10.1002/ags3.12058

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry2018

    • Author(s)
      Harada Sei、Hirayama Akiyoshi、Chan Queenie、Kurihara Ayako、Fukai Kota、Iida Miho、Kato Suzuka、Sugiyama Daisuke、Kuwabara Kazuyo、Takeuchi Ayano、Akiyama Miki、Okamura Tomonori、Ebbels Timothy M. D.、Elliott Paul、Tomita Masaru、Sato Asako、Suzuki Chizuru、Sugimoto Masahiro、Soga Tomoyoshi、Takebayashi Toru
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 1 Pages: e0191230-e0191230

    • DOI

      10.1371/journal.pone.0191230

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort.2018

    • Author(s)
      1)Nagata Y, Hirayama A, Ikeda S, Shirahata A, Shoji F, Maruyama M, Kayano M, Bundo M, Hattori K, Yoshida S, Goto Y, Urakami K, Soga T, Ozaki K and Niida S.
    • Journal Title

      Biomarker Research

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s40364-018-0119-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a sheathless CE-ESI-MS interface2018

    • Author(s)
      Hirayama A, Abe H, Yamaguchi N, Tabata S, Tomita M, Soga T.
    • Journal Title

      ELECTROPHORESIS

      Volume: 印刷中 Issue: 11 Pages: 1382-1389

    • DOI

      10.1002/elps.201800017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymidine Catabolism as a Metabolic Strategy for Cancer Survival2017

    • Author(s)
      Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI
    • Journal Title

      Cell Rep

      Volume: 19 Issue: 7 Pages: 1313-1321

    • DOI

      10.1016/j.celrep.2017.04.061

    • NAID

      120007001420

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017

    • Author(s)
      Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 114 Issue: 37

    • DOI

      10.1073/pnas.1710366114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism2017

    • Author(s)
      James R. Krycer, Satoshi Ohnoら全21名
    • Journal Title

      Cell Reports

      Volume: 21 Issue: 12 Pages: 3536-3547

    • DOI

      10.1016/j.celrep.2017.11.085

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis2017

    • Author(s)
      .Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T
    • Journal Title

      Gastroenterology

      Volume: 4 Issue: 4 Pages: 935-947

    • DOI

      10.1053/j.gastro.2017.11.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 陰イオン性代謝物に特化した新規メタボローム分析法の開発2017

    • Author(s)
      平山明由、田畑祥、曽我朋義
    • Organizer
      第5回 がんと代謝研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疫学研究に必要なメタボローム解析の精度管理2017

    • Author(s)
      平山明由
    • Organizer
      第45回 産業中毒・生物学的モニタリング研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Development of anionic metabolome analysis method using capillary ion chromatography-mass spectrometry2017

    • Author(s)
      Hirayama Akiyoshi、Tomita Masaru、Soga Tomoyoshi
    • Organizer
      13th Annual International Conference of the Metabolomics Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メタボロミクスを用いた新たな尿検査の可能性2016

    • Author(s)
      平山明由、湯澤由紀夫
    • Organizer
      日本臨床検査自動化学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-09-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] メタボローム解析技術を用いたCKDの尿中バイオマーカー探索2015

    • Author(s)
      平山明由、秋山真一、尾崎武徳、松尾清一、曽我朋義、丸山彰一
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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