Regulation of neuronal spine by ubiquitination
Project/Area Number |
15K21769
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Research Category |
Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Foundation for Biomedical Research and Innovation at Kobe |
Principal Investigator |
KAWABE Hiroshi 公益財団法人神戸医療産業都市推進機構, 上席研究員 (00582454)
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Project Period (FY) |
2017 – 2019
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥57,200,000 (Direct Cost: ¥44,000,000、Indirect Cost: ¥13,200,000)
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Keywords | スパイン / ユビキチン化 / 超解像顕微鏡 / 超高解像度顕微鏡 / 細胞内情報伝達 |
Outline of Final Research Achievements |
In the neuronal network, information is transferred between two neurons via synapses. Postsynapse is integrated in the dendritic spine. The size of spine is related to the number of neurotransmitter receptors on it and the regulation of spine morphology is of particular importance for the understanding of the pathology of psychiatric disorders. In our project, we studied the role of specific protein ubiquitination mediated by HECT type E3 ligases in the regulation of neuronal development including the spine formation.
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Academic Significance and Societal Importance of the Research Achievements |
本課題の研究で、これまで未知の部分が多かったユビキチン化による神経細胞発達の制御機構に関して、多くの知見が得られた。中でも知的障害を伴う発達障害であるKaufman症候群の原因遺伝子でE3ユビキチンリガーゼをコードするUbe3Bが、スパインの形成と形態を制御する機構を見出した。この成果は将来的に知的障害の原因の解明や治療に発展する可能性がある。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020
Author(s)
Luo, L.、19名略、Sinclair, J. L.、Stogsdill, J. A.、Traunmuller, L.、Wang, J.、Wortel, J.、 You, W.、 Abumaria, N.、 Beier, K. T.、 Brose, N.、 Burgess, H. A.、 Cepko, C. L.、 Cloutier, J. F.、 Eroglu, C.、 Goebbels, S.、 Kaeser, P. S.、 Kay, J. N.、 Lu, W.、 Luo, L.、 Mandai, K.、15名略、Kawabe, H.、 Craig, A. M.
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Journal Title
Neuron
Volume: 106
Issue: 1
Pages: 37-65
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.2020
Author(s)
Ambrozkiewicz MC*, Borisova E, Schwark M, Ripamonti S, Schaub T, Smorodchenko A, Weber AI, Rhee HJ, Altas B, Yilmaz R, Mueller S, Piepkorn L, Horan ST, Straussberg R, Zaqout S, Jahn O, Dere E, Rosario M, Boehm-Sturm P, Borck G, Willig K, Rhee JS, Tarabykin V, and Kawabe H. * *=Corresponding authors
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Journal Title
Molecular Psychiatry
Volume: 106
Issue: 6
Pages: 1980-1995
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination2018
Author(s)
Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M
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Journal Title
Cellular Microbiology
Volume: e12846
Issue: 8
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Deletion of Nedd4-2 results in progressive kidney disease in mice.2017
Author(s)
Henshall, T. L., Manning, J. A., Alfassy, O. S., Goel, P., Boase, N. A., Kawabe, H., and Kumar, S.
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Journal Title
Cell Death and Differentiation
Volume: 24
Issue: 12
Pages: 2150-2160
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.2017
Author(s)
Pei, G., Buijze, H., Liu, H., Moura-Alves, P., Goosmann, C., Brinkmann, V., Kawabe, H., Dorhoi, A., and Kaufmann, S.H.E.
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Journal Title
Autophagy
Volume: 13
Issue: 12
Pages: 2041-2055
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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