Isoflurane induces cardioprotection is dependent on caveolae and autophagy(Fostering Joint International Research)

• Project/Area Number: 15KK0344
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: TSUTSUMI Yasuo 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (90523499)
• Research Collaborator: Roth David M. カリフォルニア大学サンディエゴ校, 麻酔科, 教授 ; TANAKA Katsuya 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (30263841) ; SAKAI Yoko 徳島大学, 病院, 特任准教授 (90711862) ; TSUTSUMI Rie 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (80510172)
• Project Period (FY): 2016 – 2018
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
• Keywords: 心肥大 / オートファジー / 細胞膜マイクロドメイン / マイクロドメイン / 心筋肥大

Outline of Final Research Achievements

Sarcolemmal invaginations, microdomains, localize molecules involved in cardiac protection. However, the mechanisms for this protection are poorly understood. In response to chronic stress, the heart undergoes hypertrophy that can progress to adverse remodeling and heart failure. The subcellular organization of signaling components in highly ordered lipid microdomains within the plasma membrane helps provide spatial and temporal regulation of signaling. In the current study, we show that caveolin-3 over-expression attenuates cardiac hypertrophy and would be involved in autophagy expression and signaling.

Academic Significance and Societal Importance of the Research Achievements

日本では、ガンが死亡原因の1 位であると言われているが、心血管障害に基づく死亡はガン以上になると推測される。また、我が国では超高齢化社会を迎えて加齢による心血管障害が急速に増加しており、その対策は患者自身のQOL や生命予後のみならず、医療経済面からも極めて重要な課題である。一方、心不全の病態を考えたときに心筋肥大は重要な過程であり、そのメカニズムについては未だ必ずしも明らかになっていない。そこで本国際共同研究は、心筋肥大に対し細胞膜マイクロドメイン及がどのように関与するかを明らかにし、心不全の病態解明に寄与することを研究目的とする。

Research Products

• [Int'l Joint Research] University of California(米国) (2018)
• [Int'l Joint Research] University of California(米国) (2017)
• [Journal Article] 心筋保護作用と神経体液性因子 (2018)
  • Author(s): 里見志帆、堤保夫
  • Journal Title: 循環制御 Volume: 39 Pages: 162-164
  • Peer Reviewed
• [Journal Article] Noninvasive continuous blood pressure monitoring by the ClearSight system during robot-assisted laparoscopic radical prostatectomy. (2018)
  • Author(s): Yoko Sakai, Yasuo M. Tsutsumi, Takuro Oyama, Chiaki Murakami, Nami Kakuta, and Katsuya Tanaka.
  • Journal Title: J Med Invest Volume: 65 Pages: 69-73
  • NAID: 130006575619
  • Peer Reviewed / Open Access
• [Journal Article] Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions. (2018)
  • Author(s): Takuro Oyama, Nami Kakuta, Naoji Mita, Shinji Kawahito, Katsuya Tanaka, and Yasuo M. Tsutsumi
  • Journal Title: Clin Nutri Exp Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury (2017)
  • Author(s): Naoji Mita, Shinji Kawahito, Tomohiro Soga, Kazumi Takaishi, Hiroshi Kitahata, Munehide Matsuhisa, Mitsuo Shimada, Hiroyuki Kinoshita, Yasuo M Tsutsumi, Katsuya Tanaka
  • Journal Title: Journal of Artificial Organs Volume: 1 Issue: 1 Pages: 76-83
  • DOI: 10.1007/s10047-016-0925-6
  • Peer Reviewed
• [Journal Article] Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers (2017)
  • Author(s): Yasuo M. Tsutsumi, Takuro Oyama, Nami Kakuta, Yousuke T. Horikawa, Katsuyoshi Kume, Yoko Sakai, Rie Tsutsumi, and Katsuya Tanaka.
  • Journal Title: J Anesth Volume: 31 Issue: 3 Pages: 472-475
  • DOI: 10.1007/s00540-017-2355-x
  • NAID: 40021224363
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Comparison of Fosaprepitant and Ondansetron for Preventing Postoperative Nausea and Vomiting in Moderate to High Risk Patients: A Retrospective Database Analysis (2017)
  • Author(s): Chiaki Murakami, Nami Kakuta, Katsuyoshi Kume, Yoko Sakai, Asuka Kasai, Takuro Oyama, Katsuya Tanaka, and Yasuo M. Tsutsumi
  • Journal Title: Biomed Res Int Volume: 2017 Pages: 1-5
  • DOI: 10.1155/2017/5703528
  • NAID: 120006535022
  • Peer Reviewed / Open Access
• [Journal Article] Anesthetic Management of a Patient With Multiple Sclerosis (2017)
  • Author(s): Naohiro Ohshita, Shoko Gamoh, Masahiko Kanazumi, Masahiro Nakajima, Yoshihiro Momota, and Yasuo M. Tsutsumi
  • Journal Title: Anesth Prog Volume: 64 Issue: 2 Pages: 97-101
  • DOI: 10.2344/anpr-64-02-10
  • Peer Reviewed
• [Journal Article] Anesthetic management of a patient with unruptured sinus of valsalva aneurysm with right ventricular outflow tract obstruction. (2016)
  • Author(s): Naoji Mita, Shinji Kawahito, Tomohiro Soga, Tosiko Katayama, Narutomo Wakamatsu, Kawahara Tomiya, Nami Kakuta, Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuya Tanaka, Kazumi Takaishi and Hiroshi Kitahata
  • Journal Title: Circulation Journal Volume: 37 Pages: 195-198
  • NAID: 130005187639
  • Peer Reviewed / Open Access
• [Journal Article] カリウムチャネルと循環 (2016)
  • Author(s): 川人 伸次, 曽我 朋宏, 箕田 直治, 堤 保夫, 田中 克哉, 高石 和美, 北畑 洋, 木下 浩之
  • Journal Title: 循環制御 Volume: 37 Pages: 181-184
  • NAID: 130005187655
  • Peer Reviewed / Open Access
• [Presentation] レニン-アンギオテンシンシステムを介した心筋保護作用 (2018)
  • Author(s): 堤保夫
  • Organizer: 第39回日本循環制御医学会総会
  • Invited
• [Presentation] Glucose transporter-4 mediates acute isoflurane-induced preconditioning in vivo rabbits. (2018)
  • Author(s): Takuro Oyama, Yuta Uemura, Nami Kakuta, Yasuo M. Tsutsumi, and Katsuya Tanaka.
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Int'l Joint Research
• [Presentation] Effect of jelly type carbohydrate on metabolism and evaluation of its excretion in healthy subjects. (2017)
  • Author(s): Takuro Oyama, Nami Kakuta, Asuka Kasai, Naoji Mita, Katsuyoshi Kume, Katsuya Tanaka, and Yasuo M. Tsutsumi.
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Int'l Joint Research
• [Presentation] The effect of intraoperative glucose load on metabolism in patients with diabetes mellitus. (2017)
  • Author(s): Asuka Kasai, Kohei Fukuta, Katsuya Tanaka, Nami Kakuta, and Yasuo M. Tsutsumi.
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Int'l Joint Research
• [Presentation] The influence of glucose load on metabolism in elderly patients during surgery using remifentanil-induced anesthesia. (2017)
  • Author(s): Kohei Fukuta, Asuka Kasai, Katsuya Tanaka, Yoko Sakai, and Yasuo M. Tsutsumi.
  • Organizer: American Society of Anesthesiologist Annual Meeting
  • Int'l Joint Research
• [Remarks] 徳島大学医学部麻酔科・疼痛治療医学分野 業績集
  • URL: http://tokudaimasui.jp/study/