Chemical genetic approach toward eradication of noxious parasitic weed Striga hermonthica
| Project/Area Number |
15KT0031
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund |
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| Section | 特設分野 |
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| Research Field |
Food Cycle Research
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| Research Institution | Nagoya University |
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Principal Investigator |
Tsuchiya Yuichiro 名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 (00442989)
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| Co-Investigator(Renkei-kenkyūsha) |
URAGUCHI Daisuke 名古屋大学, 工学研究科, 准教授 (70426328)
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| Research Collaborator |
KUWATA Keiko
SATO Ayato
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| Project Period (FY) |
2015-07-10 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | ストリゴラクトン / 植物ホルモン / 寄生植物 / ストライガ / 食料問題 / 自殺発芽 / ストリゴラクトン受容体 / ケミカルバイオロジー / 食糧問題 |
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| Outline of Final Research Achievements |
A nixious parasitic plant called Striga hermonthica (Striga) represents a major threat to food security in Africa. In this research project, I focused on a host-depent germination mechanism in Striga and use it to develop a specific herbicide that lead the seeds to "suicide germination". The developed molecule (code name : SAMR690), which is composed of synthetic scaffold connected with the active core structure of strigolactones, exhibits extraordinary potency in stimulating Striga germination at femto-molar range without impinging on beneficial functions in the host strigolactone-related processes. Most importantly, the three-step procedure for synthesizing SAMO-Me-690 greatly increases the potential for Striga eradication via suicide germination campaigns in Africa.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Probing strigolactone receptors in Striga hermonthica with fluorescence.2015
Author(s)
Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
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Journal Title
Science
Volume: 349
Issue: 6250
Pages: 864-869
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Structure-function analysis identifies highly sensitive strigolactone receptors in Striga.2015
Author(s)
Toh, S., Holbrook-Smith, D., Stogios, P.J., Onopriyenko, O., Lumba, S., Tsuchiya, Y., Savchenko, A., and McCourt, P.
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Journal Title
Science
Volume: 350
Issue: 6257
Pages: 203-207
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2017
Author(s)
Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
Organizer
2nd Edition of the International Congress on Strigolactones
Place of Presentation
Trino, Italy
Year and Date
2017-03-27
Related Report
Int'l Joint Research / Invited
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[Presentation] Probing strigolactone receptors in Striga hermonthica with fluorescence.2016
Author(s)
Tsuchiya, Y., Yoshimura, M., Sato, Y., Kuwata, K., Toh, S., Holbrook-Smith, D., Zhang, H., McCourt, P., Itami, K., Kinoshita, T. and Hagihara, S.
Organizer
The International Plant Growth Substances Association Meeting
Place of Presentation
Toronto, Canada
Year and Date
2016-06-21
Related Report
Int'l Joint Research / Invited
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