| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
We have designed a new catalyst system constituted of optically active Broensted acid and metal-supported catalyst, in which each catalyst activates the substrate and molecular hydrogen. Furthermore, the catalyst system has been applied to the asymmetric hydrogenation of quinolines and imines.
The hydrogenation of 2-phenylquinoline was attempted with various combinations of the Broensted acid and metal-supported catalyst. We found that chiral BINOL-based phosphoric acid or sulfonimide allows the hydrogenation to proceed with a moderate enantioselectivity. In particular, the chiral binaphthyl-based sulfonimide bearing 3,5-di(tert-butyl)phenyl groups at its 3,3'-positions exhibited the highest enantioselectivity, giving the desired product with 36% ee.
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