Molecular base of the defenses against infection by IgM and IgA
| Project/Area Number |
16017215
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
SHIBUYA Akira University of Tsukuba, Professor, 人間総合科学研究科, 教授 (80216027)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HONDA shin-ichiro University of Tsukuba, Lecturer, 人間総合科学研究科, 講師 (60360640)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2005: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 2004: ¥7,500,000 (Direct Cost: ¥7,500,000)
|
|---|
| Keywords | IgM / IgA Fccdat / Fcα / μR / Marginal zone B cell / follicular dendritic cell / CXCL13 / Fc(alpha) / (mu)receptor / 液性免疫 / 抗体 / 自然免疫 / 獲得免疫 / 感染症 |
|---|
| Research Abstract |
IgM plays pivotal role in innate immunity by initiating classical complement cascade. Recently, an novel Fc receptor for IgM and IgA, Fcα/μR, was finaly cloned, but its involvement in IgM-mediated immunity was unclear. Here, we show that marginal zone B (MZB) cells and follicular dendritic cells (FDC) preferentially express Fcα/μR. In Fcα/μR-deficient mice, although GC formation against TD antigen was normal, that against TI antigen was enhanced, in which both B cells and FDC were involved. Formation of antigen-IgM complex decreased BCR-mediated activation and complement dependent antigen deposition of B cells via IgM-Fcα/μR interaction. Fcα/μR-deficient mice showed enhanced antigen retention by MZB cells and FDC, and CXCL13 expression in lymphoid organ in response to TI antigen. Moreover, TI antigen induced GC formation in Fcα/μR-deficient mice result in the affinity maturation of IgG3. Abrogation of complement pathway completely attenuated these phenotypes. Collectively, Fcα/μR may exert fine-tuning mechanism of IgM-mediated immune responses against TI antigens by interacting with the complement cascades.
|
Report
(3 results)
Research Products
(30 results)
-
-
-
[Journal Article] Critical role of M. tuberculosis for dendritic cell maturation to induce collagen-induced arthritis in H-2b background of C57BL/6 mice.2006
Author(s)
Kai H, Shibuya K, Wang Y, Kameta H, Kameyama T, Tahara-Hanaoka S, Miyamoto A, Honda S, Matsumoto I, Koyama A, Sumida T, Shibuva A.
-
Journal Title
Immunology. 118
Pages: 233-239
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Journal Article] A specific CpG demethylation in the human IL-2 gene promoter as an epigenetic memory.2006
Author(s)
Murayama A, Sakura K, Nakayama M, Yasuzawa K, Fujita E, Wang Y, Ushijima T, Shibuya K, Shibuya A, Kawabe Y, Yanagisawa J.
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Positional identification of an asthma susceptibility gene on human chromosome 5q332005
Author(s)
Noguchi, E., Yokouchi, Y., Zhang, J., Shibuya, K., Shibuya, A., Bannai, M., Tokunaga, K., Doi, H., Tamari, M., Shimizu, M., Shirakawa, T., Shibasaki, M., Ichikawa, K., Arinami, T.
-
Journal Title
Am J Respir Crit Care Med 172
Pages: 183-8
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Journal Article] Suppression of eosinophilic airway inflammation by treatment with alpha-galactosylceramide2005
Author(s)
Morishima, Y., Ishii, Y., Kimura, T., Shibuya, A., Shibuya, K, Hegab, A.K, Iizuka, T., Kiwamoto, T., Matsuno, Y., Sakamoto, T., Nomura, A., Taniguchi, M., Sekizawa, K.
-
Journal Title
Eur J Immunol 35
Pages: 2803-2814
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-
-
-
-
-
-
-
