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Diagnosis, Epidemiology, and Chemoprevention of Cancer

Research Project

Project/Area Number 16061101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAMURA Yusuke  The University of Tokyo, 医科学研究所, 教授 (70217909)

Co-Investigator(Kenkyū-buntansha) 稲澤 譲治  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
浜島 信之  名古屋大学, 大学院・医学系研究科, 教授 (30172969)
上田 龍三  名古屋市立大学, 大学院・医学系研究科, 教授 (20142169)
高橋 隆  名古屋大学, 大学院・医学系研究科, 教授 (50231395)
田島 和雄  愛知県がんセンター, 研究所, 所長 (30150212)
Co-Investigator(Renkei-kenkyūsha) INAZAWA Johji  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
HAMAJIMA Nobuyuki  名古屋大学, 大学院・医学系研究科, 教授 (30172969)
ABURATANI Hiroyuki  東京大学, 先端科学技術研究センター, 教授 (10202657)
UEDA Ryuzo  名古屋市立大学, 大学院・医学研究科, 教授 (20142169)
TAKAHASHI Takashi  名古屋大学, 大学院・医学系研究科, 教授 (50231395)
TAJIMA Kazuo  愛知県がんセンター, 研究所, 所長 (30150212)
TSUGANE Shoichiro  国立がん研究センター, 予防研究部, 部長 (40179982)
MIYAZONO Kohei  東京大学, 大学院・医学系研究科, 教授 (90209908)
Project Period (FY) 2004 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2008: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsオーダーメイド医療 / 分子標的 / 民族疫学 / プロテオミクス / 化学予防 / SNP / ゲノム
Research Abstract

To investigate genetic factors and establish the policy how to prevent cancer, we constructed a large cohort study by participation of multi centers in Japan. By March 31, 2010, we have enrolled nearly 48,000 individuals from nine locations in Japan and have been seeking the genetic factors and environment factors, and also investigating their interactions. In addition, we have performed systematic genomics and proteomics analysis to investigate genes involved in development and progression of cancer. Through the genome-wide expression profile analysis and genome-wide association analysis using SNPs, we identified genes susceptible to cancers and those characterizing individual caners. Such information can be applied for the establishment of personalized medicine. Furthermore, through molecular epidemiological approaches in which we compared the differences between Japanese population and other Asian populations, we attempted to identify the factors that make differences in the cancer incidence among these countries.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (46 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (39 results) (of which Peer Reviewed: 13 results) Presentation (7 results)

  • [Journal Article] Novel lipogenic enzyme ELOVL7 involves in prostate cancer growth through saturated long-chain fatty acid metabolism.2009

    • Author(s)
      K. Tamura, A. Makino, F. Hullin-Masuda, T. Kobayashi, M. Furihata, S. Chung, S. Ashida, T. Miki, T. Fujioka, T. Shuin, Y. Nakamura, H. Nakagawa
    • Journal Title

      Cancer Research 69

      Pages: 8133-8140

    • Related Report
      2009 Final Research Report
  • [Journal Article] Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.2009

    • Author(s)
      T. Ueki, J. -H. Park, T. Nishidate, K. Kijima, K. Hirata, Y. Nakamura, T. Katagiri
    • Journal Title

      Cancer Research 69

      Pages: 8752-8760

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer.2009

    • Author(s)
      A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H. Nakayama, Y. Miyagi, E. Tsuchiya, N. Kohno, Y. Nakamura, Y. Daigo
    • Journal Title

      Cancer Research 69

      Pages: 6694-6703

    • Related Report
      2009 Final Research Report
  • [Journal Article] A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.2009

    • Author(s)
      Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W. Chantratita, Y. Nakamura, K. Matsuda
    • Journal Title

      Nature Genetics 41

      Pages: 591-595

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel lipogenic enzyme ELOVL7 involves in prostate cancer growth through saturated long-chain fatty acid metabolism2009

    • Author(s)
      K.Tamura, et al.
    • Journal Title

      Cancer Research 69

      Pages: 8133-8140

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells2009

    • Author(s)
      T.Ueki, et al.
    • Journal Title

      Cancer Research 69

      Pages: 8752-8760

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer2009

    • Author(s)
      A.Takano, et al.
    • Journal Title

      Cancer Research 69

      Pages: 6694-6703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of association of genetic variations in HLA-DP locus with chronic hepatitis B in Asian population through genome2009

    • Author(s)
      Kamatani Y., et.al.
    • Journal Title

      Nature Genetics (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth.2008

    • Author(s)
      M. Hosokawa, K. Kashiwaya, M. Furihara, H. Eguchi, H. Ohigashi, O. Ishikawa, Y. Shinomura, K. Imai, Y. Nakamura, H. Nakagawa
    • Journal Title

      Cancer Science 99

      Pages: 1626-1632

    • NAID

      10024009979

    • Related Report
      2009 Final Research Report
  • [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.2008

    • Author(s)
      C. Fukukawa, H. Hanaoka, S. Nagayama, T. Tsunoda, J. Toguchida, K. Endo, Y. Nakamura, T. Katagiri
    • Journal Title

      Cancer Science 99

      Pages: 432-440

    • NAID

      10024002974

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of KIF2C/MCAK overexpression in mammary carcinogenesis.2008

    • Author(s)
      A. Shimo, C. Tanikawa, T. Nishidate, K. Matsuda, M. -L. Lin, J. -H. Park, T. Ohta, K. Hirata, M. Fukuda, Y. Nakamura, T. Katagiri
    • Journal Title

      Cancer Science 99

      Pages: 62-70

    • Related Report
      2009 Final Research Report
  • [Journal Article] Involvement of KIF2C/MCAK overexpression in mammary carcinog enesis2008

    • Author(s)
      Shimo A., et.al.
    • Journal Title

      Cancer Science 99

      Pages: 62-70

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel 5a-steroid reductase(SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer2008

    • Author(s)
      Uemura M., et.al.
    • Journal Title

      Cancer Science 99

      Pages: 81-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZDIO2008

    • Author(s)
      Fukukawa C., et.al.
    • Journal Title

      Cancer Science 99

      Pages: 432-440

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.2007

    • Author(s)
      M. Kanehira, T. Katagiri, A. Shimo, R. Takata, T. Shuin, T. Miki, T. Fujioka, Y. Nakamura
    • Journal Title

      Cancer Research 67

      Pages: 3276-3285

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.2007

    • Author(s)
      T. Yamabuki, A. Takano, S. Hayama, N. Ishikawa, T. Kato, M. Miyamoto, T. Ito, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, S. Kondo, Y. Nakamura, Y. Daigo
    • Journal Title

      Cancer Research 67

      Pages: 2517-2525

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.2007

    • Author(s)
      N. Ishikawa, A. Takano, W. Yasui, K. Inai, H. Nishimura, H. Ito, Y. Miyagi, H. Nakayama, M. Fujita, M. Hosokawa, E. Tsuchiya, N. Kohno, Y. Nakamura, Y. Daigo
    • Journal Title

      Cancer Research 67

      Pages: 11601-11611

    • Related Report
      2009 Final Research Report
  • [Journal Article] Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.2007

    • Author(s)
      Kanehira M., et. al.
    • Journal Title

      Cancer Research 67

      Pages: 3276-3285

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DKK1 as a novel serological and prognostic biomarker for lung and esophageal carcinomas.2007

    • Author(s)
      Yamabuki T., et. al.
    • Journal Title

      Cancer Research 67

      Pages: 2517-252

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy.2007

    • Author(s)
      Takata R., et. al.
    • Journal Title

      Cancer Science 98

      Pages: 113-117

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic role of KIAA0101 interacting with PCNA in pancreatic cancer.2007

    • Author(s)
      Hosokawa M., et. al.
    • Journal Title

      Cancer Research 67

      Pages: 2568-2576

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and activation of CDCA8 by AURKB plays a significant role in human lung carcinogenesis.2007

    • Author(s)
      Hayama S., et. al.
    • Journal Title

      Cancer Research 67

      Pages: 4113-4122

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MELK, maternal embryonic leucinezipper kinase, involved in mammary carcinogenesis through interaction with Bc1-G, a pro-apoptotic member of Bc1-2 family.2007

    • Author(s)
      Lin M. -L., et. al.
    • Journal Title

      Breast Cancer Research 9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer.2006

    • Author(s)
      J. -H. Park, M. -l. Lin, T. Nishidate, Y. Nakamura, T. Katagiri
    • Journal Title

      Cancer Research 66

      Pages: 9186-9195

    • Related Report
      2009 Final Research Report
  • [Journal Article] Enhanced SMYD3 expression is essential for the growth of breast cancer cells.2006

    • Author(s)
      R. Hamamoto, F.P. Silva, M. Tsuge, T. Nishidate, T. Katagiri, Y. Nakamura, Y. Furukawa
    • Journal Title

      Cancer Science 97

      Pages: 113-118

    • NAID

      10020388459

    • Related Report
      2009 Final Research Report
  • [Journal Article] Frequent silencing of the candidate tumor suppressor PCDH2O by epigenetic mechanism in non-small-cell lung cancers.2006

    • Author(s)
      Imoto I., et al.
    • Journal Title

      Cancer Res. 66

      Pages: 4617-4626

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T., et al.
    • Journal Title

      J Clin Oncol. 24

      Pages: 1679-1688

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between serum pepsinogens and polymorphism of PTPNll encoding SHP-2 among Helicobacter pylori seropositive Japanese.2006

    • Author(s)
      Goto Y., et al.
    • Journal Title

      Int J Cancer. 118

      Pages: 203-208

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target.2006

    • Author(s)
      Ito H., et al.
    • Journal Title

      Clin Cancer Res. 12

      Pages: 3257-3264

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.2005

    • Author(s)
      M. Tsuge, R. Hamamoto, F.P. Silva, Y. Ohnishi, K. Chayama, N. Kamatani, Y. Furukawa, Y. Nakamura
    • Journal Title

      Nature Genetics 37

      Pages: 1104-1107

    • Related Report
      2009 Final Research Report
  • [Journal Article] Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.2005

    • Author(s)
      C. Furukawa, Y. Daigo, N. Ishikawa, T. Kato, T. Ito, E. Tsuchiya, S. Sone, Y. Nakamura
    • Journal Title

      Cancer Research 65

      Pages: 7102-7110

    • Related Report
      2009 Final Research Report
  • [Journal Article] SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.2004

    • Author(s)
      Hamamoto, R.et al.
    • Journal Title

      Nat Cell Biol. 6

      Pages: 731-740

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alteration in copy numbers of genes as a mechanism for acquired drug resistance.2004

    • Author(s)
      Yasui, K.et al.
    • Journal Title

      Cancer Research 64

      Pages: 1403-1410

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Helicobacter pylori eradication as a preventive tool against gastric cancer.2004

    • Author(s)
      Hamajima, N.et al.
    • Journal Title

      Asian Pac Cancer Prev 5

      Pages: 246-252

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Defucosylated chimeric anti-CCR4 IgG1 with enhanced antiboy-dependent cellular cytotoxicity shows potent therapeutic anctiviy to T cell leukemia and lymphoma.2004

    • Author(s)
      Niwa, R.et al.
    • Journal Title

      Cancer Research 64

      Pages: 2127-2133

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gene expression-based, individualized outcome prediction of surgically treated lung cancer patients.2004

    • Author(s)
      Tomida, S.et al.
    • Journal Title

      Oncogene 23

      Pages: 5360-5370

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Cyp19 gene codon 39 Tyr/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese.2004

    • Author(s)
      Hirose, K.et al.
    • Journal Title

      Cancer Epidemiol, Biomarkers & Prev. 13

      Pages: 1404-1411

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Secular trends in cancer mortality among Japanese immigrants in the state of Sao Paulo, Brazil, 1979-2001.

    • Author(s)
      Iwasaki M., et al.
    • Journal Title

      Eur.J.Cancer Prev. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of the Alcohol-Dehydrogenase (ADH)1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese.

    • Author(s)
      Matsuo K., et al.
    • Journal Title

      Hum.Mutat. (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] From cancer genomics to cancer treatment2010

    • Author(s)
      中村祐輔
    • Organizer
      8th Joint Coference of the American Association for Cancer Research and the Japanese Cancer Association.
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2010-02-05
    • Related Report
      2009 Final Research Report
  • [Presentation] From cancer genomics to cancer treatment2010

    • Author(s)
      中村祐輔
    • Organizer
      8th Joint Coference of the American Association for Cancer Research and the Japanese Cancer Association
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2010-02-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] がんゲノム研究からトランスレーショナルリサーチへ2008

    • Author(s)
      中村祐輔
    • Organizer
      第67回日本癌学会学術総会・第46回日本癌治療学会合同企画
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] がんゲノム研究からがん分子標的治療薬開発に向けて2007

    • Author(s)
      中村祐輔
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2009 Final Research Report
  • [Presentation] がんゲノム研究からがん分子標的治療薬開発に向けて2007

    • Author(s)
      中村祐輔
    • Organizer
      第66回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] From cancer genomics to cancer clinic2006

    • Author(s)
      中村祐輔
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2006-09-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 個別化治療の現状と展望2005

    • Author(s)
      中村祐輔
    • Organizer
      第64回日本癌学会学術総会
    • Place of Presentation
      北海道厚生年金会館
    • Year and Date
      2005-09-14
    • Related Report
      2009 Final Research Report

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Published: 2004-04-01   Modified: 2018-03-28  

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