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Analysis of molecular biology of epilepsy

Research Project

Project/Area Number 16109006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionHirosaki University

Principal Investigator

KANEKO Sunao  Hirosaki University, 大学院・医学研究科, 教授 (40106852)

Co-Investigator(Kenkyū-buntansha) WADA Kazumaru  弘前大学, 大学院・保健学研究科, 教授 (60241486)
OKADA Motohiro  三重大学, 大学院・医学系研究科, 教授 (10281916)
YASUI-FURUKORI Norio  弘前大学, 医学部附属病院, 講師 (20333734)
SHIMIZU Toshio  弘前大学, 大学院・理工学研究科, 教授 (00110750)
KOJIMA Toshio  理化学研究所, ゲノム情報比較解析研究チーム, チームリーダー (00311340)
UENO Shinya  弘前大学, 大学院・医学研究科, 教授 (00312158)
FUKUSAWA Masashi  弘前大学, 農学生命科学部, 准教授 (10231557)
NAKAGAWA Kazuko  熊本大学, 大学院・医学薬学研究部, 教授 (20284747)
HIROSE Shinichi  福岡大学, 医学部, 教授 (60248515)
YAMAKAWA Kazuhiro  理化学研究所, 神経遺伝研究チーム, チームリーダー (30241235)
若林 孝一  弘前大学, 大学院・医学研究科, 教授 (50240768)
佐藤 敬  弘前大学, 医学部, 教授 (20125438)
Co-Investigator(Renkei-kenkyūsha) SATOH Kei  弘前大学, 大学院・医学研究科, 教授 (20125438)
TSUJI Shoji  東京大学, 医学部附属病院, 教授 (70150612)
KUWANO Ryozo  新潟大学, 脳研究所, 准教授 (20111734)
ARAKI Kimi  熊本大学, 発生医学研究センター, 准教授 (90211705)
WAKABAYASHI Koichi  弘前大学, 大学院・医学研究科, 教授 (50240768)
Project Period (FY) 2004 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥119,860,000 (Direct Cost: ¥92,200,000、Indirect Cost: ¥27,660,000)
Fiscal Year 2008: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2007: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2006: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2005: ¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2004: ¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Keywordsゲノム / シグナル伝達 / 神経科学 / 脳神経疾患 / 遺伝子 / 脳神経学 / 脳神経疾愚 / てんかん / 個別化治療 / Epilepsy / gene / polymorohism / CYP / ion channel / receptor / treatment / transporter
Research Abstract

(1)各種てんかん類型の責任遺伝子を同定し、モデル動物の基準を満たす世界初のヒトてんかん遺伝子導入モデル動物作出に成功した。このラットを用い、分子病態を解析し、病態補正の可能性、その臨界期の存在を明らかにし、根治療法開発への突破口を開いた。(2)遺伝情報から最適の抗てんかん薬(AED)の種類と至適量を選択する個別化治療開発の基本フレームを提案した。(3)てんかんの遺伝子診断用DNA chip(プロトタイプ)を世界に先駆けて開発した。

Report

(6 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (332 results)

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article (257 results) (of which Peer Reviewed: 75 results) Presentation (52 results) Book (16 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Journal Article] Physico-chemical property changes of amino acid residue accompanied with missense mutations in SCN1A affect the epilepsy phenotype severity2009

    • Author(s)
      Kanai K, Yoshida S, Hirose S, Oguni H, Kuwabara S, Sawai S, Hiraga A, Fukuma G, Iwasa H, Kojima T, and Kaneko S.
    • Journal Title

      JMG2009 (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC)2009

    • Author(s)
      Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y.
    • Journal Title

      EpilepsyRes 84(1)

      Pages: 82-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequence Selection for Multiple Alignments of Transmembrane Proteins2009

    • Author(s)
      Nishio T, Ohta T, Kaneko S, and Shimizu T.
    • Journal Title

      Information 12

      Pages: 235-42

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC)2009

    • Author(s)
      Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y.
    • Journal Title

      Epilepsy Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin2009

    • Author(s)
      Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada. M.
    • Journal Title

      Epilepsy Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex2009

    • Author(s)
      Yamamura S, Ohoyama K, Hamaguchi T, Nakagawa M, Suzuki D, Matsumoto T, Motomura E, Tanii H, Shiroyama T, Okada M
    • Journal Title

      Br J Pharmacol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors2009

    • Author(s)
      Yamamura S, Saito. H, Suzuki N, kashimoto S, Hamaguchi H, Ohoyama K, Suzuki D, Kanehara S, Nakagawa M, Shiroyama T, Okada M.
    • Journal Title

      Neurosci Lett (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions2009

    • Author(s)
      Ishii A, Fukuma G, Uehara. A, Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Yasumoto S, Okada M, Kaneko S, Mitsudome A, Hirose S.
    • Journal Title

      Brain Dev 31(1)

      Pages: 27-33

    • NAID

      10025578186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSCAM deficiency causes loss of pre-inspiratoru neuron synchroneity and perinatal death2009

    • Author(s)
      Amano K, Fujii M, Arata S, Tojima T, Ogawa M, Shimohata A, Furuichi T, Itohara S, Kamiguchi H, Korenberg J. R, Arata A, Yamakawa K.
    • Journal Title

      J Neurosci 29(9)

      Pages: 2984-96

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efhcl deficiency causes spontaneous myoclonus and increasedse izure susceptibility2009

    • Author(s)
      Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, and Yamakawa K.
    • Journal Title

      Hum. Mol Genet 18(6)

      Pages: 1099-1109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel de novo splice-site mutation of SCN1A in a patient with partial epilepsy with febrile seizures plus2009

    • Author(s)
      Kumakura A, Ito M, Hata D, Oh N, Kurahashi H, Wang JW, Hirose S.
    • Journal Title

      Brain Dev 31(2)

      Pages: 179-82

    • NAID

      10025578995

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese2009

    • Author(s)
      Matsunaga M, Yamazaki H, Kiyotani K, Iwano S, Saruwatari J, Nakagawa K, Soyama A, Ozawa S, Sawada J, Kashiyama E, Kinoshita M, Kamataki T.
    • Journal Title

      Drug Metab Dispos 37(4)

      Pages: 699-701

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence Sehection for Multiple Alignments of Transmembrane Proteins2009

    • Author(s)
      Nishio T, Ohta T, Kaneko S, and Shimizu T.
    • Journal Title

      Information 12

      Pages: 235-42

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione S-transferase Al polymorphism as a risk factor for smoking-related type 2 diabetes in Japanese2009

    • Author(s)
      Oniki K, Umemoto Y, Nagata R, Hori M, Mihara S, Marubayashi T, Nakagawa K.
    • Journal Title

      Toxicol Lett 178

      Pages: 143-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between SCN1A polymorphism and carbamazepine-resistant epilepsy2008

    • Author(s)
      Abe T, Seo T, Ishitsu T, Nakagawa T, Hori M, Nakagawa K.
    • Journal Title

      Br J Clin Pharmacol 66

      Pages: 304-307

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance2008

    • Author(s)
      Okada Y, Seo T, Wanibuchi A, HashimotoN, Higa Y, Ishitsu T, Nakagawa K.
    • Journal Title

      Ther Drug Monit 30

      Pages: 540-543

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epilepsy Genetic Study Group Japan. Genome-wide identification of febrile seizure and releted epilepsy phenotype loci2008

    • Author(s)
      Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K,Fujita H, Hirosa S, Kaneko S.
    • Journal Title

      Epilepsy & Seizure 1(1)

      Pages: 30-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of individualized medicine for epilepsy based on genetic information2008

    • Author(s)
      Kaneko S, Yoshida S, Kanai K, Yasui-Furukori N, & Iwasa H.
    • Journal Title

      ExpertRevClin Pharmacol 1(5)

      Pages: 661-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype2008

    • Author(s)
      Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahata T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H,Kijima H, Takano Y, Mitsudome A,Kaneko S, Hirose S.
    • Journal Title

      J Neurosci 28(47)

      Pages: 12465-76

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microchromosomal deletions involving SCN1A and adjacent genes ins evere myoclonic epilepsy in infancy2008

    • Author(s)
      Wang JW, Kurahashi H, Ishii A, Kojima T, Ohfu M, Inoue T, Ogawa A, Yasumoto S, Oguni H, Kure S, Fujii T, Ito M, Okuno T, Shirasaka Y, Natsume J, Hasegawa A, Konagaya A, Kaneko S, Hirose S.
    • Journal Title

      Epilepsia 49(9)

      Pages: 1528-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel mutations in Myoclonin1/EFHC1 in sporadic and tamilial juvenile myoclonic epilepsy2008

    • Author(s)
      Medina MT, Suzuki T, Alonso ME, Duron RM, Matinaz IE, Bailey JN, Bai D, Inoue Y, Yoshimura I, Kaneko S, Montoya MC, Ochoa AJ, Tanaka M, Machado-Salas J, Fujimoto S, Ito M, Hamano S, Sugita K, Ueda Y, Osawa M, Oguni H, Rubio-Donnadieu F, Yamakawa K, and Deidacio-Escueta AV.
    • Journal Title

      Neurology 70(22)

      Pages: 2137-44

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between glutathione S-transferase A1, M1 and T1 polymorphisms and hypertension2008

    • Author(s)
      Oniki K, Hori M, Takata K, Yokoyama T, Mihara S, Marubayashi T. Nakagawa K.
    • Journal Title

      Pharmacogenet Genomics 18

      Pages: 275-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for elevated serum γ-glutamyltransferase in valproic acid-treated patients2008

    • Author(s)
      Fukushima Y, Seo T, Hashimoto N, Higa Y, Ishitsu T, Nakagawa K.
    • Journal Title

      Clin Chim Acta 389

      Pages: 98-102

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCC2 haplotype is not associated with drug-resistant epilepsy2008

    • Author(s)
      Seo T, Ishitsu T, Oniki K, Abe T, Shuto T, Nakagawa K.
    • Journal Title

      J Pharm Pharmacol 60

      Pages: 631-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients2008

    • Author(s)
      Goto S, Seo T, Hagiwara T, Ueda K, Yamauchi T, Nagata S, Ando Y, Ishitsu T, Nakagawa K.
    • Journal Title

      J Pharm Pharmacol 60

      Pages: 267-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactive effect of smoking and paraoxonase-1 genotype on the lung function decline2008

    • Author(s)
      Seo T, Pahwa P, McDuffie HH, Y, Nakada N, Goto S, Ghosh S, Nakagawa K.
    • Journal Title

      Ann Epidemiol 18

      Pages: 330-4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 2C19 polymorphisms have an impact on the efficacy of clobazam therapy2008

    • Author(s)
      Seo T, Nagata R, Ishitsu T, Takaishi C, Hori M, Nakagawa K.
    • Journal Title

      Pharmacogenomics 9

      Pages: 527-37

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population estimation of the effects of cytochrome P450 2C19 and 3A5 polymorphisms on zonisamide clearance2008

    • Author(s)
      Okada Y, Seo T, Wanibuchi A, Hashimoto N, Higa Y, Ishitsu T, Nakagawa K.
    • Journal Title

      Ther Drug Monit 30

      Pages: 540-3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide identification of febrile seizure and related epilepsy phenotype loci2008

    • Author(s)
      Yoshida S, Miyashita A, Kuwano R, Kojima T, Sasaki T, Zhu G, Kanai K, Fujita H, Hirosa S, Kaneko S, & Epilepsy Genetic Study Group Japan.
    • Journal Title

      Epilepsy & Seizure 1(1)

      Pages: 30-9

    • NAID

      130000061687

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of individualized medicine for epilepsy based on genetic information2008

    • Author(s)
      Kaneko S, Yoshida S, Kanai K, Yasui-Furukori N, & Iwasa H.
    • Journal Title

      Expert Rev Clin Pharmacol 1(5)

      Pages: 661-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype2008

    • Author(s)
      Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahata T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S.
    • Journal Title

      J Neurosci 28(49)

      Pages: 12465-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bemegride lengthens seizure duration electric convulsive therepy in a schizophrenic patients with increased seizure threshold2008

    • Author(s)
      Katagai H, Yasui-Furukori N, Kikuchi A, Kaneko S.
    • Journal Title

      J ECT (Epub ahead of print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Memory trace dependence onnumber of stimuli in magnetic mismatch negativity2008

    • Author(s)
      Matsuoka T, Yabe H, Asai R, Hara E, Kaneko S.
    • Journal Title

      Neuroreport 19(10)

      Pages: 1003-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulation2008

    • Author(s)
      Fujii A, Yasui-Furukori N, Nakagami T, Niioka T, Saito M, Sato Y, and Kaneko S.
    • Journal Title

      Design, Development & Therapy Drug 2

      Pages: 139-44

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dipole Source Analysis of Temporal Slow Waves in the Elderly2008

    • Author(s)
      Motomura E, Inui K, Ogawa H, Nakase S, Hamanaka K, Honda T, Shiroyama T, Matsumoto T, Komori T, Okada M, Kakigi R.
    • Journal Title

      Neuropsychobiology 57

      Pages: 9-13

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens2008

    • Author(s)
      Nishida A, Tanii H, Nishimura Y, Kajiki N, Inoue K, Okada M, Sasaki T, Okazaki Y.
    • Journal Title

      Schizophr Res 99

      Pages: 125-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A functional near-infrared spectroscopy study on the basic word order in Japanese2008

    • Author(s)
      Nishimura Y, Sugisaki K, Hattori N, Inokuchi Y, Nishimura Y, Ogawa M, Okada M, Okazaki Y, Taki W, Yamamoto T, Yoshida E, Avano S.
    • Journal Title

      Neuroreport 19

      Pages: 915-19

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caffeine-inducible ATP release is mediated by Ca^<2+>-signal trans ducins system from the endonlasmic reticulum to mitochondria2008

    • Author(s)
      Katsuragi T, Sato C, Ueho S, Segawa M, and Migita K.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmac ol 387(1)

      Pages: 93-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental changes in KCNQ2 and KCNQ3 expression in human brain : possible contribution to the age-dependent etiology of benign familial neonatal convulsions2008

    • Author(s)
      Kanaumi T, Takashima S, Iwasaki H, Itoh M, Mitsudome A, Hirose S.
    • Journal Title

      Brain Dev 30(5)

      Pages: 362-9

    • NAID

      10025577003

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy2008

    • Author(s)
      Uehara A, Nakamura Y, Shioya T, Hirose S, Yasukochi M, Uehara K.
    • Journal Title

      J Membr Biol 222(2)

      Pages: 55-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microchromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy2008

    • Author(s)
      Wang JW, Kurahashi H, Ishii A, Kojima T, Ohfu M, Inoue T, Ogawa A, Yasumoto S, Oguni H, Kure S, Fujii T, Ito M, Okuno T, Shirasaka Y, Natsume J, Hasegawa A, Konagaya A, Kaneko S, Hirose S.
    • Journal Title

      Epilepsia 49(9)

      Pages: 1528-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new family of transcription factors2008

    • Author(s)
      Yamada Y, Wang H. Y, Fukuzawa M, Barton G. J. and Williams, JG
    • Journal Title

      Development 135

      Pages: 3093-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mutations in Myocloninl/EFHC1 in sporadic and tamilial juvenile myoclonic epilepsy2008

    • Author(s)
      Medina MT, Suzuki T, Alonso ME, Duron RM, Matinaz IE, Bailey JN, Bai D, Inoue Y, Yoshimura I, Kaneko S, Montoya MC, Ochoa AJ, Tanaka M, Machado-Salas J, Fujimoto S, Ito M, Hamano S, Sugita K, Ueda Y, Osawa M, Oguni H, Rubio-Donnadieu F, Yamakawa K, and Deidacio-Escueta AV.
    • Journal Title

      Neurology 70(22 pt 2)

      Pages: 2137-44

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monozygotic twins with severe myoclonic epilepsy in infancy discordant for clinical features2008

    • Author(s)
      Miyama S, Goto T, Inoue Y, Yamakawa K.
    • Journal Title

      Pediat Neurol 39(2)

      Pages: 120-2

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential expression of Efhcl/myocloninl in choroid plexus and ependymal cell cilia2008

    • Author(s)
      Suzuki T, Inoue I, Yamagata T, Morita N, Furuichi T, Yamakawa K.
    • Journal Title

      Biochem Biophys Res Commun 367

      Pages: 226-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder2008

    • Author(s)
      Amano K, Yamada K, Iwayama Y, Detera-Wadleigh SD, Hattori E, Toyota T, Tokunaga K, Yoshikawa T, Yamakawa K.
    • Journal Title

      Psychiatr Genet 18

      Pages: 1-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance Evaluation of Loop-Structured-Computer by Applying Pairwise Seauence Alignment2008

    • Author(s)
      Ichijo K, Kikuchi N, Yoshioka Y, and Shimizu T.
    • Journal Title

      Information 11

      Pages: 351-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro chromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy.2008

    • Author(s)
      Wang, J., Kurahashi, H., Ishii, A., Kojima, T., Ohfu, T., Inoue, T., Ogawa, A., Yasumoto S., Oguni, H., Kure, T., Fujii, T., Ito, M., Okuno T., Shirasaka, Y., Nakatsu, J., Hasegawa, A., Konagaya, A., Kaneko, S. & Hirose S.
    • Journal Title

      Epilepsia (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New-onset diabetic ketoacidosis in a schizophrenic patients with multiple autoimmune during treatment with risperidone.2008

    • Author(s)
      Sato, Y., Yasui-Furukori, N. & Kaneko, S.
    • Journal Title

      Prog. Neuro-Psychopharmacol. Biol. 32

      Pages: 577-578

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor2007

    • Author(s)
      Yoshida S, Okada M, Zhu G, Kaneko S.
    • Journal Title

      Neuropharmacology 52(7)

      Pages: 1538-46

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in brief #962.Online2007

    • Author(s)
      Singh B, Monteil A, Bidaud I, Sugimoto Y, Suzuki T, Hamano S, Oguni H, Osawa M, Alonso ME, Delgado-Escueta AV, Inoue Y, Yasui-Furukori N, Kaneko S, Lory P Yamakawa K.
    • Journal Title

      Hum Mutat 28(5)

      Pages: 524-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons : a Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation2007

    • Author(s)
      Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa K.
    • Journal Title

      J Neurosc 27(22)

      Pages: 5903-14

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patients with a sodium channel alpha 1 gene mutation show wide phenotypic variation.2007

    • Author(s)
      Osaka, H., Ogiwara, I. Mazaki, F., Okamura, N., Yamashita, S., Iai, M., Yamada, M., Kurosawa, K., Iwamoto, H., Yasui-Furukori, N., Kaneko. S., Fujisawa, T., Inoue, Y. & Yamakawa, K.
    • Journal Title

      Epilepsy Res 75(1)

      Pages: 46-51

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational analysis of CACNA1G in idiopathic generalized epilepsy. Mutation in beief #962. Online.2007

    • Author(s)
      Singh, B., Monteil, A., Bidaud, I., Sugimoto, Y., Suzuki, T., Hamano, S., Oguni, H., Osawa, M., Alonso, ME., Delgada-Escueta, AV., Inoue, Y., Yasui-Furukori, N., Kaneko, S., Lory, P. & Yamakawa, K.
    • Journal Title

      Hum Mutat 28(5)

      Pages: 524-525

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Terbinafine increases the plasma concentration of paroxetine after a single oral administration of paroxetine in healthy subjects.2007

    • Author(s)
      Yasui-Furukori, N., Saito, M., Inoue, Y., Niioka, T., Sato, Y., Tsuchimine, S. % Kaneko, S.
    • Journal Title

      Eur. J. Clin. Pharmacol. 63

      Pages: 51-56

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor.2007

    • Author(s)
      Yoshida, S., Okada, M., Zhu, G. & Kaneko, S.
    • Journal Title

      Neuropharmacol. 52(7)

      Pages: 1538-1546

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of itraconazole on pharmacokinetics of paroxetine: The role of gut transporters.2007

    • Author(s)
      Yasui-Furukori, N., Saito, M., Niioka, T., Inoue, Y., Sato, Y. & Kaneko, S.
    • Journal Title

      Ther: Drug Monit., 29(1)

      Pages: 45-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different serum concentrations of steady-state valproic acid in two sustained-release formulation.2007

    • Author(s)
      Yasui-Furukori, N., Saito, M., Niioka, T., Inoue, Y., Sato, Y. Fuiji, A. & Kaneko, S.
    • Journal Title

      Psychiat. Clin. Neurosci., 61

      Pages: 308-312

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between CYP2D6 polymorphisms and personality trait in Japanese.2007

    • Author(s)
      Iwashima, K., Yasui-Furukori, N., Kaneda, A., Saito, M., Nakagami, T., Sato, Y. & Kaneko, S.
    • Journal Title

      Brit. J. Clin. Pharmacol. 64(1)

      Pages: 96-99

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality types and coping style in hemodislysis patients.2007

    • Author(s)
      Kidachi, R., Kikuchi, A, Nishizawa, Y., Hiruma, T. & Kaneko, S.
    • Journal Title

      Psychiat & Clin. Neurosci., 61

      Pages: 339-347

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Staphylococcal enterotoxin induceces emesis though increasing serotonin release in intestine is downregulated by cannbinoid receptor 1.2007

    • Author(s)
      Hu, DL., Zhu, G, Mori, F., Omoe, K., Okada, M., Wakabayashi, K., Kaneko, S., Shinagawa, K. & Nakane A.
    • Journal Title

      Cell. Microbiol., 9(9)

      Pages: 2267-2277

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening of AP3M2 in Japanese epilepsy patients.2007

    • Author(s)
      Huang, M., Okada, M., Nakatsu, F., Oguni, H., Ito, m M., Morita, K., Nakafuji, H., Hirose, S., Sakaki, Y., Kaneko, S., Ohno, H. & Kojima, T.
    • Journal Title

      Brain & development, 29

      Pages: 462-467

    • NAID

      10024136602

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ssociation between cytochrome P450(CYP)2C19 polymorphisms and harm avoidance in Japanese.2007

    • Author(s)
      Yasui-Furukori, N., Kaneda, A., Iwashima, K., Saito, M., Nakagami, T., Tsuchimine, S. & Kaneko, S. A,
    • Journal Title

      Am. J. Med. Genet. Part B 144B

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective electroconvulsive therapy in a 92-year-old dementic patients with psychotic feature.2007

    • Author(s)
      Katagai, H., Yasui-Furukori, N., Kikuchi, A., & Kaneko, S.
    • Journal Title

      Psychiat & Clin. Neurosci. 61

      Pages: 61-61

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between major multidrug resistance 1(MDR1)gene polymorphisms and plasma concentration of prolactin during risperidone treatment in schizophrenic patients.2007

    • Author(s)
      Yasui-Furukori, N, Tsuchimine, S., Saito, M., Nakagami, T., Sato, Y. & Kaneko, S.
    • Journal Title

      Prog. Neuro-Psychopharmacol. Biol. 31

      Pages: 1230-1234

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミオクロニー発作.2007

    • Author(s)
      岩佐博人, 兼子直.
    • Journal Title

      Clin. Neurosci. 25(3),

      Pages: 303-305

    • Related Report
      2007 Annual Research Report
  • [Journal Article] てんかんの分子病態解明への展望.2007

    • Author(s)
      兼子直.
    • Journal Title

      Medical Science Digest 33(4)

      Pages: 782-783

    • Related Report
      2007 Annual Research Report
  • [Journal Article] てんかんの遺伝子研究かん見えてくる個別化治療の可能性.2007

    • Author(s)
      兼子直, 藤井学, 吉田秀一.
    • Journal Title

      臨床精神薬理 10(4)

      Pages: 617-623

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 非定型抗精神病薬の副作用に関する薬理遺伝学研究.2007

    • Author(s)
      兼子直.
    • Journal Title

      厚生労働省科学研究費補助金(こころの健康科学研究事業)分担研究報告書

      Pages: 13-16

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ヒトてんかんと遺伝子導入モデル動物を用いたてんかんの病態解明.2007

    • Author(s)
      廣瀬伸一, 岡田元宏, 朱剛, 上野伸哉, 吉田淑子, 福間五龍, 斎藤亮, 高野行夫, 兼子直, 満留昭久.
    • Journal Title

      てんかん治療研究振興財団研究年報 18

      Pages: 49-54

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Chrna 4に異常を持つ遺伝子改変モデル動物の神経科学的解析.2007

    • Author(s)
      廣瀬伸一, 岡田元宏, 朱剛, 上野伸哉, 吉田淑子, 福間五龍, 斎藤亮, 高野行夫, 兼子直, 満留昭久.
    • Journal Title

      厚生労働省精神・神経疾患研究委託費(16指-3)研究報告書

      Pages: 81-86

    • Related Report
      2007 Annual Research Report
  • [Journal Article] てんかんの責任遺伝子探索と遺伝子多型に基づいた個別化治療の開発.2007

    • Author(s)
      兼子直, 岩佐博人, 古郡規雄, 岡田元宏, 土嶺章子, 佐々木智美, 藤井学, 吉田秀一, 廣瀬伸一, 伊藤正利, 小国弘量, 大澤真木子, 前澤真理子, 小島俊男, 金井数明, 和田一丸.
    • Journal Title

      厚生労働省精神・神経疾患研究委託費(16指-3)研究報告書

      Pages: 87-93

    • Related Report
      2007 Annual Research Report
  • [Journal Article] てんかん部分発作に対するgabapentinの長期投与試験-多施設共同非肓検試験-.2007

    • Author(s)
      山内俊雄, 兼子直, 八木和一, 荒川明雄.
    • Journal Title

      臨床精神薬理 10(10)

      Pages: 1893-1908

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 徐放性バルプロ酸ナトリウム製剤の体内薬物動態の比較検討.2007

    • Author(s)
      古郡規雄, 兼子直.
    • Journal Title

      Pharma Medica 25(11)

      Pages: 127-131

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 青森県の精神医療の現状と課題.2007

    • Author(s)
      兼子直, 朱剛.
    • Journal Title

      精神科 11(3)

      Pages: 224-227

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ミスマッチ陰性電位研究における二つの重要課題.2007

    • Author(s)
      矢部博興, 松岡貴志, 朝井廉, 兼子直.
    • Journal Title

      臨床脳波 49(12)

      Pages: 735-739

    • Related Report
      2007 Annual Research Report
  • [Journal Article] てんかん.2007

    • Author(s)
      兼子直, 和田一丸.
    • Journal Title

      臨床と研究 84(2)

      Pages: 57-61

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 妊娠中の向精神薬治療.2007

    • Author(s)
      藤井学, 古郡規雄, 兼子直.
    • Journal Title

      臨床精神医学 36(増刊号)

      Pages: 299-303

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors.2007

    • Author(s)
      Nishihara K, Satoh K, et al.
    • Journal Title

      Int J Mol Med 19(1)

      Pages: 129-141

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential regulation of CREB and ERK phosphorylation through corticotrophin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells.2007

    • Author(s)
      Kageyama K, Satoh K, et al.
    • Journal Title

      Mol Cell Endocrinol 263(1, 2)

      Pages: 90-102

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal kerationocytes.2007

    • Author(s)
      Kitamura H, Satoh K, et al.
    • Journal Title

      J Dermatol Sci 45(2)

      Pages: 127-134

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice.2007

    • Author(s)
      Hoshii T, Takeo T, Nakagata N, Takeya M, Araki K, et al.
    • Journal Title

      Biology of Reproduction 76

      Pages: 303-313

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasia.2007

    • Author(s)
      Tsuji S, et al.
    • Journal Title

      Movement Disord (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multiple families with multiple system atrophy.2007

    • Author(s)
      Tsuji S, et al.
    • Journal Title

      (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel locus for benign hereditary chorea with adult-onset maps to chromosome 8q21.3-q23.3.2007

    • Author(s)
      Shimohata K, Kuwano R, et al.
    • Journal Title

      Brain (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mutation screening of AP3M2 in Japanese epilepsy patients.2007

    • Author(s)
      Hung MC, Okada M, Nakatsu F, Oguni H, Ito M, Morita K, Nagafuji H, Hirose S, Sakaki Y, Kaneko S, Ohno H, Kojima T
    • Journal Title

      Brain Dev-Jpn (in press)

    • NAID

      10024136602

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mutation analysis of CACNA1G in idiopathic generalized epilepsy.2007

    • Author(s)
      Singh B, Monteil A, Bidaud I, Sugomoto Y, Suzuki T, Hamano S, Oguni H, Osawa M, Alonso ME, Eseueta AD, Inoue Y, Yasui=Furukori N, Kaneko S, Lory K, Yamakawa K
    • Journal Title

      Hum Mutat (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Insertion of {alpha} 7 nictinic receptors at neocortical layer V GABAergic synapses is induced by a Benzodiazepine. Midazolam.2007

    • Author(s)
      Yamamoto S, Ueno S, et al.
    • Journal Title

      Cereb Cortex (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.2007

    • Author(s)
      Yamada J, Ueno S, et al.
    • Journal Title

      Cereb Cortex (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array2006

    • Author(s)
      Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakaki Y, Kaneko S.
    • Journal Title

      BiochemBiophys Res Commun 341

      Pages: 792-796

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releasesassociated with Ca^<2+>-induced Ca^<2+>releasing systems2006

    • Author(s)
      Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S.
    • Journal Title

      Epilepsy Res. 71(2-3)

      Pages: 107-16

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Ca^<2+>-induced Ca^<2+>releasing system in interlerkin-1beta-associatedadenosine release2006

    • Author(s)
      Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S.
    • Journal Title

      Eur J Pharmacol 532(3)

      Pages: 246-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-type creatine kinase activates neuron-specific K^+-Clco-transporter KCC22006

    • Author(s)
      Inoue K, Yamada J, Ueno S, Fukuda A.
    • Journal Title

      J Neurochem 96(2)

      Pages: 598-608

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Ca^<2+>-induced Ca^<2-> releasing system in interleukin-1 β-associated adenosine release.2006

    • Author(s)
      Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S
    • Journal Title

      Eur J Pharmacol 532

      Pages: 246-252

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Autho's reply : Hydroxylation of lansoprazole in poor metabolizers of CYP2C19.2006

    • Author(s)
      Yasui-Furukori N, Uno T, Kaneko S, Tateishi T
    • Journal Title

      Brit J Clin Pharmacol 61(3)

      Pages: 361-362

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array.2006

    • Author(s)
      Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakaki Y, Kaneko S
    • Journal Title

      Biochem Bioph Res Co 341(3)

      Pages: 792-796

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Digitalis intoxiction induced by paroxetine co-administration.2006

    • Author(s)
      Yasui-Furukori N, Kaneko S
    • Journal Title

      Lancet 367

      Pages: 788-788

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients : A preliminary study.2006

    • Author(s)
      Yasui-Furukori N, Saito M, Nakagami T, Kaneda A, Tateishi T, Kaneko S
    • Journal Title

      ProgNeuro-Psychoph & Biol Psychiat 30

      Pages: 286-291

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Co-localization of β-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • NAID

      10020387387

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Treatment of partial seizure with gabapentin : Double-blind, placebo-controlled, parallel-group study.2006

    • Author(s)
      Yamauchi T, Kaneko S, Yagi K, Sase S
    • Journal Title

      Psychiat Clin Neurosci 60

      Pages: 507-515

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of interleukin-1 β on hippocampal glutamate and GABA releases associated wuth Ca^<2+>-induced Ca^<2+> releasing systems.2006

    • Author(s)
      Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S
    • Journal Title

      Epilepsy Res 71(2-3)

      Pages: 107-116

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a shingle time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time corve.2006

    • Author(s)
      Niioka T, Yasui-Furukori N, Uno T, Sugawara K, Kaneko S, Tateishi T
    • Journal Title

      Ther Drug Monit 28(3)

      Pages: 321-325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phenotypes and genotypes in epilepsy with febrile seizures plus.2006

    • Author(s)
      Ito M, Yamakawa K, Sugawara T, Hirose S, Fukuma G, Kaneko S
    • Journal Title

      Epilepsy Res 28(3)

      Pages: 308-311

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Regeneration of megakaryocytopoiesis and thrombopoiesis stem cells.2006

    • Author(s)
      Kashiwakura I, SatohK, et al.
    • Journal Title

      Radiat Res 166(8)

      Pages: 345-351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic risk for atheromobotic cerebral infarction in indivividuals stratified by sex or conventional risk factors for atherosclerosis.2006

    • Author(s)
      Yamaguchi S, Satoh K
    • Journal Title

      Int J Mol Med 18(5)

      Pages: 871-883

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Assessment of genetic component of hypertension.2006

    • Author(s)
      Yamada Y, Satoh K, et al.
    • Journal Title

      Am J Hypertens 19(11)

      Pages: 1158-1165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Retinoic acid-inducible gene-I is induced in gingival fibroblasts by LPS or poly IC : possible roles in interleukin-1 β, -6 and -8 expression.2006

    • Author(s)
      Kubota K, Satoh K, et al.
    • Journal Title

      Oral Misrobio Immunol 21(6)

      Pages: 399-406

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.2006

    • Author(s)
      Kuwano R, et al.
    • Journal Title

      Hum Mol Genet 15

      Pages: 2170-2182

    • NAID

      40015443849

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Propofol, an anesthetic possessing neuroprotective action against oxidative stress, promotes the process of cell death induced by H202 in rat thymocytes.2006

    • Author(s)
      Chikutei K, Ueno S, et al.
    • Journal Title

      Eur J Pharmacol 540(1-3)

      Pages: 18-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytometic analysis of lidocaine-induced cytotoxicity : a model expriment using rat thymocytes.2006

    • Author(s)
      Nishimura Y, Ueno S, et al.
    • Journal Title

      Toxicology 218(1)

      Pages: 48-57

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Brain-type creatine kinase activates neuron-specific K^+-Cl-co-transporter KCC2.2006

    • Author(s)
      Inoue K, Ueno S, et al.
    • Journal Title

      J Neurochem 96(2)

      Pages: 598-608

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hypoglycemic encephalopathy with extensive lesions in the cerebral white matter.2006

    • Author(s)
      Mori F, Nishie M, Houzen H, Yamaguchi J, Wakabayashi K
    • Journal Title

      Neuropathology 26(2)

      Pages: 147-152

    • NAID

      10020387084

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Progression patterns of neuronal loss and Lewy body pathology in the substantia nigra in Parkinson's disease.2006

    • Author(s)
      Wakabayashi K, et al.
    • Journal Title

      Parkinsonism Relat Disord 12(Suppl 2)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cardiac sympathetic denervation in Lewy body disease.2006

    • Author(s)
      Orimo S, Amino T, Takahashi A, Kojo T, Uchihara T, Mori F, Wakabayashi K, et al.
    • Journal Title

      Parkinsonism Relat Disord 12(Suppl 2)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1.2006

    • Author(s)
      Tanji K, Tanaka T, Mori F, Kito K, Takahashi H, Wakabayashi K, et al.
    • Journal Title

      Am J Pathol 169(2)

      Pages: 553-565

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship among α -synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra.2006

    • Author(s)
      Mori F, Nishie M, Kakita A, Yoshimoto M, Takahashi H, Wakabayashi K
    • Journal Title

      J Neuropathol Exp Neurol 65(8)

      Pages: 808-815

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cellular pathology in multiple system atrophy.2006

    • Author(s)
      Wakabayashi K, et al.
    • Journal Title

      Neuropathology 26(4)

      Pages: 338-345

    • NAID

      10018059103

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I.2006

    • Author(s)
      Imaizumi T, Sashinami H, Mori F, Matsumiya T, Yoshida H, Nakane A, Wakabayashi K, et al.
    • Journal Title

      Microbiol Immunol 50(10)

      Pages: 811-815

    • NAID

      10020554990

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy.2006

    • Author(s)
      Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, et al.
    • Journal Title

      Acta Neuropathol 113(1)

      Pages: 81-86

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages.2006

    • Author(s)
      Sato F, Imaizumi T, Sashinami H, Yoshida H, Kusumi T, Mori F, Wakabayashi K, et al.
    • Journal Title

      Biochem Biophys Res Commun 354(2)

      Pages: 608-612

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype.2006

    • Author(s)
      Kanaumi T, Hirose S, et al.
    • Journal Title

      Pediatr Neurol 34(3)

      Pages: 235-238

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A new paradigm of channelopathy in epilepsy syndrome : Intracellular trafficking abnormality of channel molecules.2006

    • Author(s)
      Hirose S
    • Journal Title

      Epilepsy Res 70S

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuropathology of methylmalonic acidemia in a child.2006

    • Author(s)
      Kanaumi T, Takashima S, Hirose S, et al.
    • Journal Title

      Pediatr Neurol 34(2)

      Pages: 156-159

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Developmental changes in the expression of GABA_A receptor alpha 1 and gamma 2 subunts in human temporal lobe, hippocampus and basal ganglia; An implication for consideration on age-related epilepsy.2006

    • Author(s)
      Kanaumi T, Takashima S, Iwasaki H, Mitsudime S, Hirose S
    • Journal Title

      Epileps Res 71

      Pages: 47-53

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel murine gene, Sickle tail (Skt), linked to the Danforth's short tail (Sd) locus, is required for normal development of the intervertebral disc.2006

    • Author(s)
      Semba K, Araki K, et al.
    • Journal Title

      Genetics 172

      Pages: 445-456

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impaired expression of Importin/karyopherin 1 leads to post-implantation lethality.2006

    • Author(s)
      Miura K, Yoshinobu K, Imaizumi T, Haruna K, Miyamoto Y, Yoneda, Y, Nakagata N, Araki M, Miyakawa T, Yamamura K, Araki K
    • Journal Title

      Biochem Biophys Res Commun 341

      Pages: 132-138

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3.2006

    • Author(s)
      Ohmuraya M, Hirota M, Araki K, et al.
    • Journal Title

      Pancreas 33

      Pages: 104-106

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice.2006

    • Author(s)
      Ito K, Kimura S, Ozasa S, Matsukura M, Ikezawa M, Yoshioka K, Ueno H, Suzuki M, Araki K, et al.
    • Journal Title

      Hum Mol Genet 15

      Pages: 2266-2275

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Negative Selection with the Diphtheria toxin A fragment Gene Improves Frequency of Cre-Mediated Cassette Exchange in ES Cells.2006

    • Author(s)
      Araki K, et al.
    • Journal Title

      J Biochem. 140

      Pages: 793-798

    • NAID

      10018840450

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of tandem repeats found in 44 prokaryotic genomes.2006

    • Author(s)
      Mizuta S, Munakata H, Aimaiti A, Oya I., Oosawa K., Shimizu T.
    • Journal Title

      In Silico Bio 16

      Pages: 147-159

    • Related Report
      2006 Annual Research Report
  • [Journal Article] How to obtain multiple alignments in which transmembrane segment regions are well aligned without inserted2006

    • Author(s)
      Kimura T, Ohta T, Nishio T, Shimizu T
    • Journal Title

      Chem-Bio Informatics Journal, under revision. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of tandem repeats found in 44 prokaryotic genomes2006

    • Author(s)
      Mizuta S, Munakata H, Aimaiti A, Oya I, Oosawa K, Shimizu T
    • Journal Title

      In Silico Biology (in press) (accepted.)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Brain-type creatine kinase activates neuron-apecific K^+-Cl^-co-transporter KCC2.2006

    • Author(s)
      Inoue K, Yamada J, Ueno S, Fukuda A
    • Journal Title

      J Neurochem 96

      Pages: 598-608

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cytometric analysis of lidocaine-induced cytotoxicity : A model experiment using rat thymocytes.2006

    • Author(s)
      Nishimura Y, Kanada A, Yamaguchi J, Horimoto K, Kobayashi M, Tatsuishi T, Kanemura K, Ueno S, Oyama Y
    • Journal Title

      Toxicology 218

      Pages: 48-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oligodendrocytes within astrocytes ("emperipolesis") in the cerebral white matter in hepatic and hypoglycemic encephalopathy.2006

    • Author(s)
      Nishie M, Mori F, Houzen H, Yamaguchi J, Jensen PH, Wakabayashi K.
    • Journal Title

      Neuropathology 26

      Pages: 62-65

    • NAID

      10020387365

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Co-localization of β-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration.2006

    • Author(s)
      Wakabayashi K, Mori F, Hasegawa M, Kusumi T, Yoshimura I, Takahashi H, Kaneko S.
    • Journal Title

      Neuropathology 26

      Pages: 66-71

    • NAID

      10020387387

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of Ca^<2+>-induced Ca^<2+> releasing system in interleukin-1 β-associated adenosine release.2006

    • Author(s)
      Zhu G, Okada M, Yoshida S, Mori F, Hirose S, Wakabayashi K, Kaneko S.
    • Journal Title

      Eur J Pharmacol 532

      Pages: 246-252

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of vasoconstricotr coupling factor 6 on gene expression profile in human vascular endothelial cells : enhanced release of asymmetric dimethylarginine.2006

    • Author(s)
      Tanaka M, Osanai T, Murakami R, Sasaki S, Tomita H, Maeda N, Satoh K, Magota K, Okumura K
    • Journal Title

      J Hypertens 24

      Pages: 489-497

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-bgeo cassette.2006

    • Author(s)
      Taniwaki, T., Haruna, K., Nakamura, H., Sekimoto, T., Oike, Y., Imaizumi, T., Saito, F., Muta, M., Soejima, Y., Utoh, A., Nakagata, N., Araki, M., Yamamura, K., Araki, K.
    • Journal Title

      Develop Growth Differ 47

      Pages: 163-172

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel murine gene, Sickle tail (Skt), linked to the Danforth's short tail (Sd) locus, is required for normal development of the intervertebral disc2006

    • Author(s)
      Semba, K., Araki, K., Li, Z., Matsumoto, K., Suzuki, M., Nakagata, N., Takagi, K., Takeya, M., Yoshinobu, K., Araki, M., Imai, K., Abe, K., Yamamura, K.
    • Journal Title

      Genetics 172

      Pages: 445-456

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impaired expression of Importin/karyopherin beta1 leads to post-implantation lethality.2006

    • Author(s)
      Miura, K., Yoshinobu, K., Imaizumi, T., Haruna, K., Miyamoto, Y., Yoneda, Y., Nakagata, N., Araki, M., Miyakawa, T., Yamamura, K., Araki, K.
    • Journal Title

      Biochem.Biophys.Res.Commun. 341

      Pages: 132-138

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors2005

    • Author(s)
      Yoshida S, Okada M, Zhu G, Kaneko S
    • Journal Title

      Epilepsy Res. 67(3)

      Pages: 153-62

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ryanodine receptor activation on neurotransmitter release and neruronal cell death following kainic acid-induced status epilepticus2005

    • Author(s)
      Mori F, Okada M, Tomiyama M, Kaneko S, Wakabayshi K.
    • Journal Title

      Epilepsy Res 65(1-2)

      Pages: 59-70

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic actions of topiramete on monamine exocytosis associated with both soluble N-ethylmateimide-sensitive factor attachment protein receptors and Ca^<2+>-induced Ca^<2+>-releasing systems2005

    • Author(s)
      Okada M, Yoshida S, Zhu G, Hirose S, Kaneko S.
    • Journal Title

      Neuroscience 134(1)

      Pages: 233-46

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex2005

    • Author(s)
      Huang CW, Ueno S, Okada M, Kaneko S.
    • Journal Title

      Epilepsy Res 67

      Pages: 51-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic action of topiramate on monoamine exocytosis associated with both soluble N-ethylmaleimide-sensitive factor attachment protein receptors and Ca^<2+>-induced Ca^<2+>-releasing systems.2005

    • Author(s)
      Okada M, Yoshida S, Zhu G, Hirose S, Kaneko S
    • Journal Title

      Neuroscience 134

      Pages: 233-246

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetics of idiopathic epilepsies.2005

    • Author(s)
      Hirose S, Mitsudome A, Okada M, Kaneko S, on behalf of The Epilepsy Study Group, Japan
    • Journal Title

      Epilepsia 46(Suppl 1)

      Pages: 38-43

    • NAID

      10016481115

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus.2005

    • Author(s)
      Mori F, Okada M, Tomiyama M, Kaneko S, Wakabayashi K
    • Journal Title

      Epilepsy Res 65(1-2)

      Pages: 59-70

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors.2005

    • Author(s)
      Yoshida S, Okada M, Zhu G, Kaneko S
    • Journal Title

      Epilepsy Res 67(3)

      Pages: 153-162

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Localisation of missense mutations in SCN1A affects epilepsy phenotype severity.2005

    • Author(s)
      Kanai K, Hirose S, Oguni H, Fukuma G, Shirasaka Y, Miyajima T, Kuwabara S, Wada K, Iwasa H, Yasumoto S, Ito M, Hattori T, Mitsudome A, Kaneko S
    • Journal Title

      Neurology Asia 9(Suppl 1)

      Pages: 144-144

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations of KCNQ2 and KCNQ3 identified in benign neonatal convulsions cause channel dysfunction despite proper expression on the cell membrane.2005

    • Author(s)
      Ishii A, Fukuma G, Yasukochi M, Uehara A, Miyajima T, Hamachi A, Yonetani M, Kaneko S, Mitsudome A, Hirose S
    • Journal Title

      Neurology Asia 9(Suppl 1)

      Pages: 146-146

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Possible pathogenesis of severe myoclonic epilepsy in infancy : A novel nonsense mutation of GABRG2 leading to aggregation of GABA receptors in neurons.2005

    • Author(s)
      Kanaumi T, Fukuma G, Ueno S, Ishii A, Haga Y, Hamachi A, Yonetani M, Itoh M, Takashima S, Kaneko S, Mitsudome A, Hirose S
    • Journal Title

      Neurology Asia 9(Suppl 1)

      Pages: 151-151

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Down-regulation of CICR gene expression by carbamazepine, via stimulation of CICR associated monoamine exocytosis.2005

    • Author(s)
      Okada M, Yoshida S, Zhu G, Ueno S, Kaneko S
    • Journal Title

      J Pharmacol Sci 97(Suppl 1)

      Pages: 78-78

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Zonisamido at clinically relevant concentrations inhibits evoked EPSP but not presynaptic fiber volley in rat frontal cortex.2005

    • Author(s)
      Huang CW, Ueno S, Okada M, Kaneko S
    • Journal Title

      J Pharmacol Sci 97(Suppl 1)

      Pages: 268-268

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Age-Dependent impaiement of GABAergic transmission in μ3B knockout mice.2005

    • Author(s)
      Zhu G, Okada M, Mori F, Nakatsu F, Yoshida S, Wakabayashi K, Ohno H, Kaneko S
    • Journal Title

      Epilepsia 46(Suppl 2)

      Pages: 2-2

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel de novo KCNQ2 mutation in a sporadic case of benign neomatal convulsions.2005

    • Author(s)
      Ishii Ai, Fukuma G, Uehara A, Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Okada M, Kaneko S, Akihisa M, Hirose S
    • Journal Title

      Epilepsia 46(Suppl 2)

      Pages: 3-4

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of carbamazepine on mechanism of Ca2+-induced Ca2+ releasing system-associated exocytosis.2005

    • Author(s)
      Okada M, Zhu Gang, Yoshida S, Mori F, Wakabayashi K, Kaneko S
    • Journal Title

      Epilepsia 46(Suppl 2)

      Pages: 15-16

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Epileptic seizure in mice deficient in μ3B subunit of AP-3B complex.2005

    • Author(s)
      Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yasa D, Manabe T, Wakabayashi K, Kaneko S, Saito T, Ohno H
    • Journal Title

      Epilepsia 46(Suppl 2)

      Pages: 67-68

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impairment of monoaminergic transmission in μ3B knockout mice.2005

    • Author(s)
      Zhu G, Okada M, Nakatsu F, Mori F, Yoshida S, Wakabayashi K, Ohno H, Kaneko S
    • Journal Title

      Epilepsia 46(Suppl 3)

      Pages: 11-12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of the gene responsible for juvenile myoclonic epilepsy.2005

    • Author(s)
      Suzuki T, Delgado-Escueta VA, Aguan K, Shi J, Hara Y, Nishida M, Numata T, Takeuchi T, Bai D, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, Yamakawa K
    • Journal Title

      Epilepsia 46(Suppl 3)

      Pages: 15-16

    • Related Report
      2005 Annual Research Report
  • [Journal Article] てんかん -責任遺伝子解明の進展とその後の課題-2005

    • Author(s)
      兼子 直, 金井数明, 岡田元宏, 桑原聡, 廣瀬伸一
    • Journal Title

      実験医学 23(5)

      Pages: 776-781

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヒトてんかんと同じ遺伝子異常をもつ組換え動物の作出2005

    • Author(s)
      岡田元宏, 朱 剛, 上野伸哉, 吉田淑子, 福間五龍, 廣瀬伸一, 兼子 直
    • Journal Title

      精神薬療研究年報 37

      Pages: 160-164

    • Related Report
      2005 Annual Research Report
  • [Journal Article] てんかんにおける認知障害とその分子基盤-遺伝子異常との関連を含めて-2005

    • Author(s)
      岩佐博人, 兼子 直
    • Journal Title

      分子精神医学 5(3)

      Pages: 284-290

    • Related Report
      2005 Annual Research Report
  • [Journal Article] てんかんの分子遺伝学研究のUp to date2005

    • Author(s)
      兼子 直, 金井数明, 福間五龍, 岡田元宏, 桑原 聡, 廣瀬伸一
    • Journal Title

      ゲノム医学 5(3)

      Pages: 241-245

    • Related Report
      2005 Annual Research Report
  • [Journal Article] てんかんの薬物療法における新たな視点-オーダーメイド治療の可能性と課題-2005

    • Author(s)
      岩佐博人, 兼子 直
    • Journal Title

      神経進歩 49(5)

      Pages: 745-756

    • Related Report
      2005 Annual Research Report
  • [Journal Article] メンデル型遺伝を示すてんかん症候群 -チャネル病を中心に-2005

    • Author(s)
      兼子 直, 和田一丸
    • Journal Title

      精神科治療学 20(Suppl)

      Pages: 364-366

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 徐放性バルプロ酸ナトリウム製剤(セレニカ【○!R】R錠200mg,デパケン【○!R】R錠R200)の体内薬物動態と生物学的同等性の比較検討2005

    • Author(s)
      古郡規雄, 近藤 毅, 兼子 直
    • Journal Title

      Pharma Medica 23(12)

      Pages: 71-75

    • Related Report
      2005 Annual Research Report
  • [Journal Article] How accurately G-protein-coupled receptors can be discriminated as 7-tms TM protein sequences from others?2005

    • Author(s)
      Inoue Y, Yamazaki Y, Shimizu T
    • Journal Title

      Biochem.Biophys.Res.Commun 338

      Pages: 1542-1546

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A proteome-wide analysis of domain architectures of prokaryotic single-spanning transmembrane proteins2005

    • Author(s)
      Arai M, Fukushi T, Satake M, Shimizu T
    • Journal Title

      Comput.Biol.Chem 29

      Pages: 379-387

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Model analysis of surfactant-polymer interaction as cooperative ligand binding to linear lattice2005

    • Author(s)
      Nishio T, Shimizu T
    • Journal Title

      Biophysical Chemistry 117

      Pages: 19-25

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of newly cloned variant of rat glycine receptor α1 subunit.2005

    • Author(s)
      Inoue K, Ueno S, Yamada J, Fukuda A
    • Journal Title

      Biochem Biophy Rea Comm 327

      Pages: 300-305

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex.2005

    • Author(s)
      Huang CW, Ueno S, Okada M, Kaneko S
    • Journal Title

      Epilepsy Res 67

      Pages: 51-60

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential functional expression of cation-C1^- cotransporter mRNAs (KCC1, KCC2, and NKCC1) in rat trigeminal nervous system.2005

    • Author(s)
      Toyoda H, Yamada J, Ueno S., Okabe A, Kato H, Sato K, Hashimoto K, Fukuda A
    • Journal Title

      Molecular Brain Res 133

      Pages: 12-18

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders.2005

    • Author(s)
      Mori F, Nishie M, Piao Y-S, Kito K, Kamitani T, Takahashi H, Wakabayashi K
    • Journal Title

      Neuropathol Appl Neurobiol 31

      Pages: 53-61

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Peculiar venous lesions in fatal hyponatremic brain edema2005

    • Author(s)
      Nishie M, Mori F, Tomita T, Nishijima M, Kaimori M, Wakabayashi K
    • Journal Title

      Neuropathology 25

      Pages: 95-98

    • NAID

      10017018923

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter : a variant of corticobasal degeneration?2005

    • Author(s)
      Tan C-F, Piao Y-S, Kakita A, Yamada M, Takano H, Tanaka M, Mano A, Makino K, Nishizawa M, Wakabayashi K, Takahashi H
    • Journal Title

      Acta Neuropathol 109

      Pages: 329-338

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease.2005

    • Author(s)
      Orimo S, Amino T, Itoh Y, Takahashi A, Kojo T, Uchihara T, Tsuchiya K, Mori F, Wakabayashi K, Takahashi H.
    • Journal Title

      Acta Neuropathol 109

      Pages: 583-588

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An autopsy case of early ("minimal change") olivopontocerebellar atrophy (multiple system atrophy-cerebellar).2005

    • Author(s)
      Wakabayashi K, Mori F, Nishie M, Oyama Y, Kurihara A, Yoshimoto M, Kuroda N.
    • Journal Title

      Acta Neuropathol 110

      Pages: 185-190

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Rhabdoid cystic papillary meningioma with diffuse subarachnoid dissemination.2005

    • Author(s)
      Wakabayashi K, Suzuki N, Mori F, Kamada M, Hatanaka M.
    • Journal Title

      Acta Neuropathol 110

      Pages: 196-198

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells.2005

    • Author(s)
      Imaizumi T, Hatakeyama M, Yamashita K, Ishikawa A, Yoshida H, Satoh K, Taima K, Mori F, Wakabayashi K.
    • Journal Title

      Endothelium 12

      Pages: 133-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Disseminated intraparenchymal microgranulomas in the brainstem in a case of CNS sarcoidosis ("sarcoid brainstem encephalitis").2005

    • Author(s)
      Nishie M, Mori F, Suzuki C, Ogawa M, Kurahashi K, Kaimori M, Wakabayashi K.
    • Journal Title

      Neuropathology 25

      Pages: 361-364

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Double-stranded RNA stimulates the expression of monocyte chemoattractant protein-1 in BEAS-2B bronchial epithelial cells.2005

    • Author(s)
      Taima K, Takanashi S, Okumura K, Imaizumi T, Kumagai M, Ishikawa A, Yoshida H, Satoh K, Fujita T
    • Journal Title

      Exp Lung Res 31(3)

      Pages: 361-375

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of RIG-I in IFN-γ/STAT1 signaling pathway in BEAS-2B cells2005

    • Author(s)
      Imaizumi T, Kumagai M, Taima K, Fujita T, Yoshida H, Satoh K
    • Journal Title

      Eur Resp J 25(6)

      Pages: 1077-1083

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells.2005

    • Author(s)
      Imaizumi T, Mori F, Hatakeyama M, Yamashita K, Ishikawa A, Taima K, Yoshida H, Wakabayashi K, Satoh K
    • Journal Title

      Endothelium 12(3)

      Pages: 133-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of peroxisome proliferator-activated receptor-γ ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide.2005

    • Author(s)
      Imaizumi T, Yamashita K, Taima K, Ishikawa A, Yoshida H, Satoh K
    • Journal Title

      Prostaglandins Other Lipid Mediat 78(1-4)

      Pages: 46-54

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetics of idiopathic epilepsies.2005

    • Author(s)
      Hirose S, Mitsudome A, Okada M, Kaneko S
    • Journal Title

      Epilepsia 46(1)

      Pages: 38-43

    • NAID

      10016481115

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutation in the NHLRC1 gene are the common causefor Lafora disease in the Japanese population.2005

    • Author(s)
      Singh S, Suzuki T, Uchiyama A, Kumada S, Moriyama N, Hirose S, Takahashi Y, Sugie H, Mizoguchi K, Inoue Y, Kimura K, Sawaishi Y, Yamakawa K, Ganesh S
    • Journal Title

      J Hum Genet 50

      Pages: 347-352

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Screening method for organic aciduria by spectrofluorometric measurement of total dicarboxyloc acids in human urine based on intramolecular excimer-forming fluroscence derivatization.2005

    • Author(s)
      Yoshida H, Araki J, Sonoda J, Nohta H, Ishida J, Hirose S, Yamaguchi M
    • Journal Title

      Anal Chimica Acta 534

      Pages: 177-183

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Carnitine palmitoyltransferase II deficiency due to a novel gene variant a patient with phabdomyolysis and ARF.2005

    • Author(s)
      Kaneko H, Uesugi N, Moriguchi A, Hirose S, Takayanagi M, Yamaguchi S, Shigematsu Y, Yasuno T, Sasatomi Y, Sait T
    • Journal Title

      Am J Kidney Dis 45

      Pages: 596-602

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Seven myoclonic epilepsy in infants -clinical analysis and relation to SCN1A, mutations.2005

    • Author(s)
      Oguni H, Hayashi K, Osawa M, Awaya Y, Fukuyama Y, Fukuma G, Hirose S, Mitsudome A, Kaneko S
    • Journal Title

      Adv Neurol 95

      Pages: 103-117

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neuropathological findings in a child with methymalonic academia.2005

    • Author(s)
      Kanaumi T, Takahashi S, Hirose S, Kodama T, Iwasaki H, Mitsudome A
    • Journal Title

      Pediatr Neurol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype running title : An infant of MELAS phenotype.2005

    • Author(s)
      Kanaumi T, Hirose S, Goto Y, Naitou E, Mitsudome A
    • Journal Title

      Pediatr Neurol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.2005

    • Author(s)
      Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, Tsuji S, Obata F
    • Journal Title

      Ann Neurol 57(6)

      Pages: 918-921

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches - Augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases2005

    • Author(s)
      Shimohata, M, Shimohata, T, Igarashi, S, Naruse, S, Tsuji, S
    • Journal Title

      J.Neurochem 93

      Pages: 654-663

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons.2005

    • Author(s)
      Miyashita T, Tabuchi A, Fukuchi M, Hara D, Kisukeda T, Shimohata T, Tsuji S, Tsuda M
    • Journal Title

      Biochem Biophys Res Commun 333(4)

      Pages: 1241-1248

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Determination of genomic breakpoints in an epileptic patient using genotyping array.2005

    • Author(s)
      Kojima T, Mukai W, Fuma D, Ueda Y, Okada M, Sakai Y, Kaneko S
    • Journal Title

      Biochem Biophys Res Commun 341(3)

      Pages: 792-796

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 inP19 cells.2005

    • Author(s)
      Oda, H., Fushimi, F., Kato, M., Kitagawa, M., Araki, K., Seki, N., Ohkubo, H.
    • Journal Title

      Biochem Biophys Res Commun 335

      Pages: 458-468

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Severe myoclonic epilepsy in infancy : clinical analysis and relation to SCN1A mutation in a Japanese cohort.2005

    • Author(s)
      Oguni H, Kaneko S, et al.
    • Journal Title

      Adv Neurol 95

      Pages: 103-107

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Role of α7-nicotinic acetylcholine receptors in titanic stimulation-induced γ oscillations in rat hippocampal slices.2005

    • Author(s)
      Wu J, Wakui M, et al.
    • Journal Title

      Neuropharmacol (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Platelet-activating factor enhances the expression of nerve growth factors in normal human astrocytes under hypoxia.2005

    • Author(s)
      Yoshida H, Satoh K, et al.
    • Journal Title

      Mol Brain Res 133

      Pages: 95-101

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Menatetrenone and vitamin D2 with calcium aupplements prevent nonverbral fracture in elderly women with Alzheimer's disease.2005

    • Author(s)
      Sato Y, Satoh K, et al.
    • Journal Title

      Bone 36

      Pages: 61-68

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mutations in EFHC1 cause juvenile myoclonic epilepsy2004

    • Author(s)
      Suzuki T, Delgado-Escueta AV, Aguan K, Alonso ME, Shi J, Hara Y, Nishida M, Numata T, Medina MT, Takeuchi T, Morita R, Bai D, Ganesh S, Sugimoto Y, Inazawa J, Bailey JN, OchoaA, Jara-Prado A, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Inoue Y, Osawa M, Kaneko S, Oguni H, Mori Y, and Yamakawa K.
    • Journal Title

      Nat Genet 36(8)

      Pages: 842-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation in EFHC1 cause juvenile myoclonic epilepsy.2004

    • Author(s)
      Suzuki T, Yamakawa K, Kaneko S, et al.
    • Journal Title

      Nature Genet 36/8

      Pages: 842-849

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Seizure phenotypes of a family with missense mutations in SCN2A.2004

    • Author(s)
      Ito M, Hirose S, et al.
    • Journal Title

      Pediatr Neurol 31/2

      Pages: 150-152

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Mutation of neuronal voltage-gated Na^+ channel alpha 1 subunit gene SCN1A in core severe myoclonic epilepsy in infancy (SMEI) and in borderline SMEI (SMEB).2004

    • Author(s)
      Fukuma G, Kaneko S, et al.
    • Journal Title

      Epilepsia 45/2

      Pages: 140-148

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.2004

    • Author(s)
      Nakatsu F, et al.
    • Journal Title

      J Cell Biol 167/2

      Pages: 293-302

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Protein kinase associated with gating and closing transmission mechanisms in temporoammonic patyway.2004

    • Author(s)
      Okada M, et al.
    • Journal Title

      Neuropharmacol 47/4

      Pages: 485-504

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of localization of missense mutations in SCN1A on epilepsy phenotype severity.2004

    • Author(s)
      Kanai K, et al.
    • Journal Title

      Neurology 63/2

      Pages: 329-334

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Evaluation of the color-coding method for searching tanden repeats in prokaryotic genomes.2004

    • Author(s)
      Mizuta S, Shimizu T, et al.
    • Journal Title

      Chem-Bio Informatics J 4/4

      Pages: 133-141

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Proteome-wide functional classification and identification of Prokaryotic transmembrane proteins by transmembrane topology similarity comparison.2004

    • Author(s)
      Arai M, Shimizu T, et al.
    • Journal Title

      Protein Sci 13

      Pages: 2170-2183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ConPred II : a consensus prediction method for obtaining transmembrane topology models with high reliability.2004

    • Author(s)
      Arai M, Shimizu T, et al.
    • Journal Title

      Nucleic Acids Res 32

      Pages: 390-393

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Internal gene duplication in the evolution of prokaryotic transmembrane proteins.2004

    • Author(s)
      Shimizu T, et al.
    • Journal Title

      J Mol Biol 339

      Pages: 1-15

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Loss of PGC-specific expression of the orphan nusleara receptor ERR-β results in reduction of germ cell number in mouse embryos.2004

    • Author(s)
      Mitsunaga K, Araki K, et al.
    • Journal Title

      Mechanisms Development 121

      Pages: 237-246

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Serine-arginine-rich muclear protein Luc71 regulates myogenesis in mice.2004

    • Author(s)
      Kimura E, Araki K, et al.
    • Journal Title

      Gene 341

      Pages: 41-47

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Both 3, 4-dihydroxyphenylalanine and dopamine release are regulated by Ca^<2+>-induced Ca^<2+> releasing system in rat stritum.2004

    • Author(s)
      Zhu G, et al.
    • Journal Title

      Neurosci Lett 362/3

      Pages: 244-248

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pharmacological discrimination of protein kinase associated exocytosis mechanisms between dopamine and 3, 4-dihydroxyphenylalanine in rat using in vivo.2004

    • Author(s)
      Zhu G, et al.
    • Journal Title

      Neurosci Lett 363/2

      Pages: 120-124

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Determination of exocytosis mechanisms DOPA in rat striatum using in vivo microdialysis.2004

    • Author(s)
      Zhu G, et al.
    • Journal Title

      Neurosci Lett 367

      Pages: 241-245

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Marital status of patients with epilepsy with special reference to the influence of epileptic seizures on the patient's married life.2004

    • Author(s)
      Wada K, et al.
    • Journal Title

      Epilepsia 45(Suppl.(8)

      Pages: 33-36

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Physical and psychomotor development in the offspring born to mothers with epilepsy.2004

    • Author(s)
      Hirano, T, et al.
    • Journal Title

      Epilepsia 45(Suppl.8)

      Pages: 53-57

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequences-SNP analysis.2004

    • Author(s)
      Abe K, Kojima T, et al.
    • Journal Title

      Genome Res 14/12

      Pages: 2439-2447

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association analysis between longevity in the Japanese population land polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.2004

    • Author(s)
      Kojima T, et al.
    • Journal Title

      Exp Gerontol 39/11-12

      Pages: 1595-1598

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Japanese SCA families with an unusual phenotype linked to a locus overlapping with SCA15 locus.2004

    • Author(s)
      Hara K, Kuwano R, Tsuji S, et al.
    • Journal Title

      Neurology 62/4

      Pages: 648-651

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A rare case of hypohidrotic ectodermal dysplasia by compound heterozygous mutations in the EDAR gene.2004

    • Author(s)
      Shimomura Y, Kuwano R, et al.
    • Journal Title

      J Invest Dermatol 123/4

      Pages: 649-655

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization.2004

    • Author(s)
      Angeli V, Satoh K, et al.
    • Journal Title

      Immunity 21

      Pages: 561-574

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells.2004

    • Author(s)
      Ishikawa A, Satoh K, et al.
    • Journal Title

      Immunol Cell Biol 82

      Pages: 410-414

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Retinoic acid-inducible gene-I is induced by interferon-γ and regulates the expression of interferon-γ stimulated gene 15 in MCF-7 cells.2004

    • Author(s)
      Cui XE, Satoh K, et al.
    • Journal Title

      Biochem Cell Biol 82

      Pages: 401-405

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Heparin inhibits IFN-γ induced fractalkine/CX3CL1 expression in human endothelial cells.2004

    • Author(s)
      Hatakeyama M, Satoh K, et al.
    • Journal Title

      Inflammation 28/1

      Pages: 7-13

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of CX3CL1/fractalkine expression in endothelial cells.2004

    • Author(s)
      Imaizumi T, Satoh K, et al.
    • Journal Title

      J Atherosclerosis Thrombosis 11/1

      Pages: 15-21

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 15-deoxy- ^<12,14>-prostaglandin J_2 inhibits the IL-1β-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells.2004

    • Author(s)
      Kumagai M, Satoh K, et al.
    • Journal Title

      Tohoku J Exp Med 202

      Pages: 69-76

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotype.2004

    • Author(s)
      Yasui-Furukori N, et al.
    • Journal Title

      Br J Clin Pahrmacol 57/4

      Pages: 487-494

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The effects of ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil.2004

    • Author(s)
      Yasui-Furukori N, et al.
    • Journal Title

      J Clin Pharmacol 44/5

      Pages: 538-542

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone : lack of impact of MDR-1 genotypes.2004

    • Author(s)
      Yasui-Furukori N, et al.
    • Journal Title

      Br J Clin Pharmacol 57/5

      Pages: 569-575

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hyperactivity of endoplasmic reticulum associated exocytosis mechanism contributes to acute phencyclidine intoxication.2004

    • Author(s)
      Zhu G, et al.
    • Journal Title

      J Pharmacol Sci 95

      Pages: 214-227

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Establishment of new cloned enzyme donor immuassays (CEDIA【○!R】) for haloperidol and bromperidol.2004

    • Author(s)
      Yasui-Furukori N, et al.
    • Journal Title

      Ther Drug Monit 26/3

      Pages: 336-341

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca^<2+> signals of rat islet β-cells by affecting L-type Ca^<2+> channels and voltage-dependent K^+ channels2004

    • Author(s)
      Suga S, Wakui M, et al.
    • Journal Title

      Cell Calcium 36

      Pages: 469-477

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca^<2+> signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells.2004

    • Author(s)
      Wu J, Wakui M, et al.
    • Journal Title

      Pflugers Arch-Eur J Physiol 448

      Pages: 592-595

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-γ.2004

    • Author(s)
      Imaizumi T, Satoh K, et al.
    • Journal Title

      Life Sci 75

      Pages: 1171-1180

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interferon-γ induces retinoic acid-inducible gene-I in endothelia cells.2004

    • Author(s)
      Imaizumi T, Satoh K, et al.
    • Journal Title

      Endothelium 11

      Pages: 169-173

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Risk factors for hip fracture among elderly patients with Alzheimer's disease.2004

    • Author(s)
      Sato Y, Satoh K, et al.
    • Journal Title

      J Neurol Sci 223

      Pages: 107-112

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Upregulation of retinoic acid-inducible gene-I in T24 urinary blander carcinoma cells stimulated with interferon-γ.2004

    • Author(s)
      Imaizumi T, Satoh K, et al.
    • Journal Title

      Tohoku J Exp Med 203

      Pages: 313-318

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abnormal calcium homeostasis in disabled stroke patients with low 25-hydroxyvitamin D.2004

    • Author(s)
      Sato Y, Satoh K, et al.
    • Journal Title

      Bone 34

      Pages: 710-715

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interleukin-I β induces matrix metalloproteinase-I expression in cultured human gingival fibroblasts : role of cyclooxygenase-2 and prostaglandin E_2.2004

    • Author(s)
      Sasaki H, Satoh K, et al.
    • Journal Title

      Oral Diseases 10

      Pages: 87-93

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Myopathy phenotype in transgenic mice expressing mutated PABPN1 as a model of oculopharyngeal muscular dystrophy.2004

    • Author(s)
      Hino H, Araki K, et al.
    • Journal Title

      Human Mol Genet 13/2

      Pages: 181-190

    • Related Report
      2004 Annual Research Report
  • [Journal Article] チャネロパチー2004

    • Author(s)
      兼子直
    • Journal Title

      分子精神医学 4/2

      Pages: 162-163

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 抗てんかん薬の分類とその特徴2004

    • Author(s)
      和田一丸, 他
    • Journal Title

      日本医師会雑誌 131/12

      Pages: 97-98

    • Related Report
      2004 Annual Research Report
  • [Journal Article] てんかんの遺伝子診断の可能性2004

    • Author(s)
      兼子直, 他
    • Journal Title

      精神経誌 106/5

      Pages: 660-670

    • NAID

      10014249833

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 熱性けいれん,熱性けいれんプラス,及び乳児重症ミオクロニーてんかんの遺伝子解析と遺伝子診断の設定2004

    • Author(s)
      兼子直, 他
    • Journal Title

      てんかん治療研究振興財団研究年報 16

      Pages: 91-100

    • NAID

      120001197367

    • Related Report
      2004 Annual Research Report
  • [Journal Article] てんかんの遺伝子2004

    • Author(s)
      兼子直, 他
    • Journal Title

      神経進歩 48/6

      Pages: 889-898

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 特発性てんかんの分子生物学2004

    • Author(s)
      廣瀬伸一
    • Journal Title

      小児神経学の進歩 33

      Pages: 60-67

    • Related Report
      2004 Annual Research Report
  • [Journal Article] GABA受容体,Kチャネル異常を示すてんかん2004

    • Author(s)
      廣瀬伸一, 他
    • Journal Title

      てんかん研究 22/3

      Pages: 160-170

    • NAID

      10016244179

    • Related Report
      2004 Annual Research Report
  • [Journal Article] イオンチャネルとてんかん2004

    • Author(s)
      廣瀬伸一
    • Journal Title

      神経進歩 48/6

      Pages: 899-905

    • Related Report
      2004 Annual Research Report
  • [Journal Article] てんかんの病態へ分子生物学で迫る2004

    • Author(s)
      廣瀬伸一
    • Journal Title

      臨床神経学 44/11

      Pages: 975-978

    • NAID

      10014115075

    • Related Report
      2004 Annual Research Report
  • [Journal Article] リバースゲノミクス的研究手法を用いた中枢系機能性疾患におけるERストレス仮説の構築2004

    • Author(s)
      岡田元宏, 他
    • Journal Title

      精神薬療基金研究年報 36

      Pages: 74-82

    • Related Report
      2004 Annual Research Report
  • [Journal Article] マイクロダイアリーシスを用いた神経伝達物質開口分泌機構の解明2004

    • Author(s)
      岡田元宏, 他
    • Journal Title

      日本神経精神薬理学雑誌 24

      Pages: 165-170

    • NAID

      10015423137

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Child neurology in asia2004

    • Author(s)
      廣瀬伸一, 他
    • Journal Title

      脳と発達 36/2

      Pages: 141-142

    • NAID

      10012951581

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 抗精神病薬の薬物動態と遺伝子多型2004

    • Author(s)
      古郡規雄, 他
    • Journal Title

      分子精神医学 4/3

      Pages: 1-5

    • Related Report
      2004 Annual Research Report
  • [Journal Article] DNA variants in coding region of EFHC1 : SNPs do not associate with juvenile myoclonic epilepsy

    • Author(s)
      Bai D, Bailey JN, Duron RM, Alonso ME, Medina MT, Martinez-Juarez IE, Suzuki T, Machado-Salas J, Ramos-Ramirez R, Tanaka M, Ortega RH, Lopez-Ruiz M, Rasmussen A, Ochoa A, Jara-Prado A, Yamakawa K, Delgado-Escueta AV.
    • Journal Title

      Epilepsia (Epub ahead of print)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 部分てんかん治療におけるトピラマートの意義.2008

    • Author(s)
      兼子直.
    • Organizer
      第35回東北てんかん談話会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-03-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかん責任遺伝子変異データベースー.2008

    • Author(s)
      吉田秀一, 金井数明, 小島俊男, 山崎祥拓, 清水俊夫, 兼子直, Epilepsy Genetic Study Group Japan.
    • Organizer
      第35回東北てんかん談話会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-03-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epilepsy and Pregnancy.2008

    • Author(s)
      Kaneko S.
    • Organizer
      International CME on Emerging Trends in Management of Epilepsy
    • Place of Presentation
      Mumbai, INDIA
    • Year and Date
      2008-01-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epilepsy and Pregnancy.2008

    • Author(s)
      Kaneko S.
    • Organizer
      International CME on Emerging Trends in Management of Epilepsy
    • Place of Presentation
      Bengalore, INDIA
    • Year and Date
      2008-01-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epilepsy and Pregnancy.2008

    • Author(s)
      Kaneko S.
    • Organizer
      International CME on Emerging Trends in Management of Epilepsy
    • Place of Presentation
      Kolkata, INDIA
    • Year and Date
      2008-01-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epilepsy and Pregnancy.2008

    • Author(s)
      Kaneko S.
    • Organizer
      International CME on Emerging Trends in Management of Epilepsy
    • Place of Presentation
      Delhi, INDIA
    • Year and Date
      2008-01-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epilepsy Genetic Study Group Japan.Development of individualizedmedicine for epilepsy based upongenetic polymorphisms2008

    • Author(s)
      Kaneko S, Yoshida S, Kanai K, Iwasa H, Yasui-Furukori N
    • Organizer
      2008International Conference onPharmacogenomics (Joint Conferencewith the 14th Annual Meeting of thePRACP)
    • Place of Presentation
      Busan, KOREA
    • Related Report
      2008 Final Research Report
  • [Presentation] S6 : Pharmacogenomics based personalized pharmacotherapy : Development of individualized medicine for epilepsy based upon gene tic polymorphisms : Potential in the combination of various res earch approaches2008

    • Author(s)
      Kaneko S, Yoshida S, Kanai K, Iwasa H, Yasui-Furukori N, and Epilepsy Genetic Study Group Japan
    • Organizer
      2008 International Conference on Pharmacogenomics (Joint Conference with the 14^<th> Annual Meeting of the PRACP)
    • Place of Presentation
      Busan, KOREA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Allele frequencies of CYP2C19 and CYP2D6 in a Japanese population2008

    • Author(s)
      Yasui-Furukori N, Uemichi T, Nobori T, Mizuno M, Shirahama S, Miyoshi Y, and Kaneko S.
    • Organizer
      2008 International Conference on Pharmacoge nomics (Joint Conference with the 14^<th> Annual Meeting of the PRACP)
    • Place of Presentation
      Busan, KOREA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genomo-waide identification of febrile seizure and related epilepsy phenotype loci2008

    • Author(s)
      Yoshida S, Miyashita A, Kuwano R, Kojima T, Zhu G, Kanai K, Fujita K, Hirano S, and Kaneko S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Xiamen. CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Determination of neurotransmitter release in a novel spontaneous epilepsy model, Prip-1 knockout mice2008

    • Author(s)
      Zhu G, Okada M, Yoshida S, Ueno S, Wakabayashi K, and Kaneko S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Applicability of new spin trap agent, 2-diphenylphosphinoyl-2-methyl-3, 4-dihydro-2H-pyrrole N-oxide, in biological system2008

    • Author(s)
      Karakawa T, Muramoto Y, Mitani Y, Kitamado M, Iwanaga T, Nabeshima T, Maruyama K, Nakagawa K, Ishida K, Sasamoto K, Sato K.
    • Organizer
      A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th International EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
    • Place of Presentation
      Fukuoka, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Superoxide scavenging activity of pirfenidone-iron complex2008

    • Author(s)
      Mitani Y, Muramoto Y, Karakawa T, Kitamado M, Iwanaga T, Nabeshima T, Maruyama K, Nakagawa K, Ishida K, Sasamoto K, Sato K.
    • Organizer
      A Joint Conference of the 13th In Vivo ESR/EPR Spectroscopy & Imaging and the 10th Inte rnational EPR Spin Trapping/Spin Labeling : Biomedical Redox Navigation (EPR2008)
    • Place of Presentation
      Fukuoka, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of Genetic Polymorphisms And Occupational Exposure to Canary Seed Dust on Longitudinal decline in pulmonary function2008

    • Author(s)
      Pahwa P, Nakagawa K, Koehncke N, McDuffie HH.
    • Organizer
      The Sixth International Symposium : Public health and the agricultural rural ecosystem
    • Place of Presentation
      Saskatoon, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association between high-risk genotypes of glutathione S-trans ferases and type 2 diabetes mellitus, non-alcoholic fatty liver disease and hypertension2008

    • Author(s)
      Nakagawa K, Fujimura Y, Umemoto Y, Oniki K, Seo T, Mihara S, Marubavashi T.
    • Organizer
      The Sixth International Symposium : Public health and the agricultural rural ecosystem
    • Place of Presentation
      Saskatoon, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] A De Novo KCNQ2 Mutation Detected in Benign Neonatal Convulsions : Possible Involvement Of Genes responsible for Rare Inherited Epilepsy in Idiopathic Epilepsy2008

    • Author(s)
      Ishii A, Fukuma G, Uehara A, Yasukochi M, Miyajima T, Makita Y, Hamachi A, Yonetani M, Inoue T, Okada M, Kaneko S, and Hirose S.
    • Organizer
      The 4^<th> Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Perinatal Characteristics of Early-Onset Sepsis in Neonatal Intensive Care Unit in Recent Years2008

    • Author(s)
      Tsutsumi M, Ohta E, Inoue T, Kinoshita R, Nakamura M, Mori T. Hirose S.
    • Organizer
      The 4^<th> Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Application of Genetic Tests for Epilepsy-are there Guidelines for Clinicians?2008

    • Author(s)
      Hirose S
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress Xiamen
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] EEG Findings on Headache with MELAS2008

    • Author(s)
      Ihara Y, Fujita T, Inoue T, Yasumoto S, Mitsudome A, Hirose S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress Xiamen
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Myoclonic-Astatic Epilepsy with Focal Spike Discharge may have Unfavourable Prognosis2008

    • Author(s)
      Ideguchi H, Inoue T, Ninomiya S, Fujita T, Nakamura N, Yasumoto S, Hirose S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress Xiamen
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Non-convulsive Status Epilepticuso of Temporal Lobe Epilepsy Misdiagnosed as a Psychosomatic Disease2008

    • Author(s)
      Fujita T, Nakamura N, Inoue T, Ninomiya S, Ihara Y, Tomonou Y, Ideguchi H, Yasumoto S. Mitsudome A. Hirose S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress Xiamen
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Psychomotor Retardation Aggravated by Infantile Non-convpislve Status Epileptics in Angelman Syndrome2008

    • Author(s)
      Ninomiya S, Nakamura N, Fujita T, Ideguchi H, Inoue T., Yasumoto S, Hirose S.
    • Organizer
      7^<th> Asian & Oceanian Epilepsy Congress Xiamen
    • Place of Presentation
      Xiamen, CHINA
    • Related Report
      2008 Annual Research Report
  • [Presentation] The present Status and Problem of Plenatal Screening of Congenital Heart Defects ; 4 Major Refernal Centers in Kyusyu, Japan2008

    • Author(s)
      Yoshikane Y, Yoshizato T, Maeno Y, Nishibatake M, Kam N, Fusazaki N, Hirose S.
    • Organizer
      The 2^<nd> Asia-Pacific Congress of Pediatrics Cordiology and Cardiac Surgery
    • Place of Presentation
      Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Retrospective Analysis of Prenatally Detected Congenital Heart Defects : Six-year Experience of 4 Institutions in Japan2008

    • Author(s)
      Yashikane Y, Yoshizato T, Meno Y, Nishibatake M, Kan N, Fusazaki N, Hirose S.
    • Organizer
      15^<th> Congress of the FAOPS
    • Place of Presentation
      Nagoya, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Study of Septicemia Due to Enterbacter Cloacae in a Tertiary Neonatal Intensive Care Unit during 1997-20072008

    • Author(s)
      Ohta E, Setoue T, Tsutsumi M, Inoue S, Kinoshita R, Nakamura M, Mori T, Ogawa A, Hirose S.
    • Organizer
      15^<th> Congress of the FAOPS
    • Place of Presentation
      Nagoya, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prognoses of the Neonates of Multiple Births Admitted in NICU in recent Years2008

    • Author(s)
      Inoue T, Tsutsumi M, Kiposhita R, Ohta E, Nakamura M, Mori T, Hirose S.
    • Organizer
      15^<th> Congress of the FAOPS
    • Place of Presentation
      Nagoya, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new mode of prespore gene regulation : DdMybF functions as a reoressor for nresnore differentiation2008

    • Author(s)
      Tomita K, Fukuzawa M.
    • Organizer
      Dictyostelium international conference
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel differentiation inducing factor with low molecular weight in Dictyostelium discoideum : its purifi cation and characte rization2008

    • Author(s)
      Takaya Y, Fukuzawa M, Hotta R, Nakagawa M, Oohata AA.
    • Organizer
      Dictyostelium international conference
    • Place of Presentation
      Tsukuba, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dictyostelium PKB/AKT related kinase may function as an activator for a putative switch of stalk formation2008

    • Author(s)
      Ochiai H, Koki, Nagayama K, Takeda K, Fukuzawa M, Takiya S, Ohmachi T.
    • Organizer
      Dictyostelium international conference
    • Place of Presentation
      Tsukube, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症薬物治療における薬物相互作用・副作用に関する文献的考察(高プロラクチン血症を中心に).2007

    • Author(s)
      古郡規雄, 斉藤まなぶ, 中神卓, 兼子直.
    • Organizer
      平成19年度精神・神経疾患研究委託費(18指-7)研究報告会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかんの個別化治療の開発に関する研究.2007

    • Author(s)
      兼子直, 岩佐博人, 古郡規雄, 岡田元宏, 土嶺章子, 佐々木智美, 藤井学, 吉田秀一, 廣瀬伸一, 石津棟暎, 小国弘量, 大澤真木子, 前澤真理子, 小島俊男, 金井数明, 和田一丸.
    • Organizer
      平成19年度精神・神経疾患研究委託費(19指-6)研究報告会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] シンポジウムI:強迫の臨床,思春期発症の摂食障害女性・A子の長期治療経過-摂食障害における強迫性をめぐって-.2007

    • Author(s)
      栗林理人, 兼子直.
    • Organizer
      第61回東北精神神経学会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかんの薬物治療-現状と展望-.2007

    • Author(s)
      兼子直.
    • Organizer
      第43回(社)日本脳神経外科学会東北支部会
    • Place of Presentation
      弘前
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかん・熱性けいれん遺伝子解析グループ.マイクロサテライトマーカーを用いたFS・GEFS+・SMEIにおける新規責任遺伝子の網羅的検索(第1報).2007

    • Author(s)
      吉田秀一, 桑野良三, 宮下哲典, 小島俊男, 佐々木智美, 朱剛, 金井数明, 伊藤正利, 藤田浩史, 廣瀬伸一, 兼子直, ,
    • Organizer
      第1回日本てんかん学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 機能性精神疾患の皮質錐体細胞回路障害のtwo hit model仮説の構築.2007

    • Author(s)
      兼子直.
    • Organizer
      平成19年度特定領域研究「統合脳」夏のワークショップ合同班会議・統合シンポジウム・サテライトシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] ミスマッチ陰性電位における時間窓統合機能内部の逸脱検出感度と刺激呈示確率との関係について.2007

    • Author(s)
      松岡貴志, 朝井廉, 原悦子, 矢部博興, 兼子直.,
    • Organizer
      第24回日本脳電磁図トポグラフィ研究会
    • Place of Presentation
      岡崎
    • Related Report
      2007 Annual Research Report
  • [Presentation] パロキセチンの薬物動態に対するイトラコナゾールの影響-消化管の役割-.2007

    • Author(s)
      古郡規雄, 斉藤まなぶ, 新岡武典, 井上義政, 佐藤靖, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症におけるリスペリドンによる治療効果と血漿薬物濃度の関係について.2007

    • Author(s)
      古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 鈴木昭仁, 三原一雄, 近藤毅, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 急性期におけるrisperidoneと選択的dopamine遮断薬の治療反応性の比較.2007

    • Author(s)
      斉藤まなぶ, 古郡規雄, 中神卓, 古郡華子, 石田正之, 田中治, 三原一雄, 鈴木昭仁, 大谷浩一, 近藤毅, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] オランザピンおよびリスペリドネ内服中の統合失調症患者のクッキーテストによる代謝性因子の比較検討.2007

    • Author(s)
      佐藤靖, 古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] リスペリドンの薬物反応性における主要MDR1遺伝子型C3435Tの役割について.2007

    • Author(s)
      中神卓, 古郡規雄, 土嶺章子, 斉藤まなぶ, 古郡華子, 高橋一志, 樋口久, 近藤毅, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 早期治療反応性を用いたリスペリドンの初期治療におけるプロラクチン反応.2007

    • Author(s)
      楠木将人, 古郡規雄, 斉藤まなぶ, 中神卓, 古郡華子, 鈴木昭仁, 近藤毅, 兼子直.
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗てんかん薬慢性投与による細胞内カルシウム放出(CICR)機構に対する発現変化の検討.2007

    • Author(s)
      吉田淑子, 岡田元宏, 朱剛, 兼子直.
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] 乳児重症ミオクロニー患者におけるSCN1A遺伝子を含んだ染色体微小欠失.2007

    • Author(s)
      倉橋宏和, 王紀文, 大府正治, 井上貴仁, 小川厚, 安元佐和, 小島俊男, 兼子直, 廣瀬伸一.
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] てんかん治療における新規抗てんかん薬の使い方-トピラマートを中心に-.2007

    • Author(s)
      兼子直.
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] 逸脱音検出時に誘発される事象関連反応に対する注意の影響.2007

    • Author(s)
      朝井廉, 矢部博興, 原悦子, 晝間臣治, 松岡貴志, 朝井春子, 兼子直.
    • Organizer
      第37回日本臨床神経生理学会学術大会
    • Place of Presentation
      宇都宮
    • Related Report
      2007 Annual Research Report
  • [Presentation] 時間統合窓(TWI)内部における逸脱呈示確率の効果について:第二報.2007

    • Author(s)
      松岡貴志, 矢部博興, 朝井廉, 原悦子, 晝間臣治, 兼子直.
    • Organizer
      第37回日本臨床神経生理学会学術大会
    • Place of Presentation
      宇都宮
    • Related Report
      2007 Annual Research Report
  • [Presentation] 日本人のTCIによる人格特性とMAO-AおよびCOMT遺伝子多型との関係について.2007

    • Author(s)
      土嶺章子, 古郡規雄, 金田絢子, 斉藤まなぶ, 中神卓, 兼子直.
    • Organizer
      第29回日本生物学的精神医学会, 第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] ドパミン受容体遺伝子多型と日本人における人格特性との関係について2007

    • Author(s)
      古郡規雄, 土嶺章子, 金田絢子, 斉藤まなぶ, 中神卓, 兼子直.
    • Organizer
      第29回日本生物学的精神医学会, 第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] ポア形成領域以外に生じたSCN1Aミスセンス変異のアミノ酸置換が表現型に与える影響.2007

    • Author(s)
      金井数明, 廣瀬伸一, 小国弘量, 福間五龍, 桑原聡, 吉田秀一, 澤井摂, 岩佐博人, 清水俊夫, 伊藤正利, 服部孝道, 兼子直.
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] DRIP-1遺伝子欠損マウスの自発性けいれん発現機序の解明.2007

    • Author(s)
      朱剛, 岡田元宏, 吉田淑子, 吉田秀一, 森秋文, 上野伸哉, 兼松隆, 若林孝一, 兼子直.
    • Organizer
      第41回日本てんかん学会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] 機能性精神疾患の皮質錐体細胞回路障害のtwo hit model仮説の構築.2007

    • Author(s)
      兼子直.
    • Organizer
      平成19年度特定領域研究「統合脳」冬のシンンポジウム
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Book] てんかんの生物学的背景-病態解明から個別化治療の開発へ-. てんかん-臨床的側面-. 松下正昭, 加藤敏, 神庭重信編. 精神医学対話.2008

    • Author(s)
      兼子直
    • Total Pages
      1064
    • Publisher
      (株)弘文堂・東京発行
    • Related Report
      2008 Final Research Report
  • [Book] Progress in genetics of severe myoclonic epilepsy in fancy. In : Fukuyama Y, Takahashi T, editors. Progress in Epileptic Disorders Biology of Seizere Susceptibility in Developing Brain. 1-32008

    • Author(s)
      Kurahashi K, Wang J, Ishii A, Fukuma G, Hamachi A, Yonetani M, Ogawa A, Ohfu M, Inoue T, Yasumoto S, Hirose S.; 2008
    • Total Pages
      734
    • Publisher
      Paris : Editions John Libbey Eurotext Montrouge
    • Related Report
      2008 Annual Research Report
  • [Book] Roadmap抗精神病薬の精神薬理を生かした重度精神疾患個別化治療(ed. by Peter JW et.al. Translating the psychopharmacology of antipsychotics to individualized treatment for severe mental illness : a roadmap). 兼子直監訳2008

    • Author(s)
      兼子直
    • Total Pages
      77
    • Publisher
      アルタ出版(株)・東京
    • Related Report
      2008 Annual Research Report
  • [Book] てんかんの生物学的背景-病態解明から個別化治療の開発ヘ-. てんかん-臨床的側面-. 松下正昭, 加藤敏, 神庭重信編. 精神医学対話. 1002-142008

    • Author(s)
      兼子直
    • Total Pages
      1064
    • Publisher
      (株)弘文堂・東京
    • Related Report
      2008 Annual Research Report
  • [Book] てんかん.コア・ローテイション精神科(改訂2版)2007

    • Author(s)
      和田一丸, 兼子直.
    • Total Pages
      426
    • Publisher
      金芳堂
    • Related Report
      2007 Annual Research Report
  • [Book] チャネロパチー.KEY WORD精神(第4版)2007

    • Author(s)
      兼子直.
    • Total Pages
      240
    • Publisher
      (株)先端医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 佐藤光源, 丹羽真一, 井上新平編:統合失調症の治寮-臨床と基礎-.2007

    • Author(s)
      森園修一郎, 菊池淳宏, 近藤毅, 兼子直.
    • Total Pages
      576
    • Publisher
      朝倉書店
    • Related Report
      2007 Annual Research Report
  • [Book] バルプロ酸の臨床薬理(改訂版)2006

    • Author(s)
      兼子直, Heinz Nau
    • Publisher
      ライフ・サイエンス
    • Related Report
      2006 Annual Research Report
  • [Book] Chaptor 6 : mechanisms of calcium-associated exocytosis of striatal dopamine and DOPA release, studied by in vivo microdialysis. (Eds by Misu Yoshimi & Goshima Yoshio), pp.89-992005

    • Author(s)
      Okada Motohiro, Zhu Gang, Yoshida Shukuko, Hirose Shinichi, Kaneko Sunao
    • Total Pages
      350
    • Publisher
      Taylor & Francis ; New York
    • Related Report
      2005 Annual Research Report
  • [Book] 「脳の世紀」推進会議(伊藤正男, 晝馬輝夫, 河西春郎, 山口陽子, 兼子直, 酒井邦嘉)編,脳を知る・創る・守る・育む,pp.100-1292005

    • Author(s)
      兼子 直
    • Total Pages
      155
    • Publisher
      (株)クバプロ,東京
    • Related Report
      2005 Annual Research Report
  • [Book] Exchangeable gene trapping. In Genetically Engineered Mice (eds Sundberg.J.P. & IchikiT.) pp.131-143.2005

    • Author(s)
      Araki, K.
    • Total Pages
      300
    • Publisher
      CRC Press, Boca Raton, USA
    • Related Report
      2005 Annual Research Report
  • [Book] イオンチャネル仮説2004

    • Author(s)
      金井数明
    • Total Pages
      391
    • Publisher
      石郷岡純編「精神疾患100の仮説(改訂版)」,星和書店,東京
    • Related Report
      2004 Annual Research Report
  • [Book] てんかん2004

    • Author(s)
      和田一丸, 他
    • Total Pages
      386
    • Publisher
      武田雅俊,鹿島春雄編集「コア・ローテイション精神科」,金芳堂,東京
    • Related Report
      2004 Annual Research Report
  • [Book] てんかんの仮説2004

    • Author(s)
      兼子直, 他
    • Total Pages
      391
    • Publisher
      石郷岡純編「精神疾患100の仮説(改訂版)」,星和書店,東京
    • Related Report
      2004 Annual Research Report
  • [Book] ニコチン性アセチルコリン受容体のアセチルコリン開口分泌機構に与える効果2004

    • Author(s)
      岡田元宏
    • Total Pages
      85
    • Publisher
      佐藤公道編集「セロトニン:最近の話題(第7回神経伝達物質研究会記録集),Excerpta Medica, Elesevier Japan, K.K.
    • Related Report
      2004 Annual Research Report
  • [Book] 妊娠とてんかん2004

    • Author(s)
      兼子直, 他
    • Total Pages
      23
    • Publisher
      武谷雄二監修「Recent Advances in Reproductive Medicine」,Excerpta Medica, Elesevier Japan, K.K., Tokyo
    • Related Report
      2004 Annual Research Report
  • [Remarks]

    • URL

      http://www.enieene.ora/mutation/

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] てんかんモデル非ヒトモデル哺乳動物2009

    • Inventor(s)
      兼子直, 廣瀬伸一
    • Industrial Property Rights Holder
      兼子直, 廣瀬伸一
    • Industrial Property Number
      2008-031002
    • Filing Date
      2009-02-10
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] てんかんモデル非ヒト哺乳動物2009

    • Inventor(s)
      兼子直, 廣瀬伸一
    • Industrial Property Rights Holder
      兼子直, 廣瀬伸一
    • Filing Date
      2009-02-10
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] てんかんモデル非ヒト哺乳動物2008

    • Inventor(s)
      廣瀬伸一, 兼子直
    • Industrial Property Rights Holder
      廣瀬伸一, 兼子直
    • Industrial Property Number
      2008-031002
    • Filing Date
      2008-02-12
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] けいれん性疾患に関連する遺伝子変異とけいれん性疾患診断方法2006

    • Inventor(s)
      小島俊男, 廣瀬伸一, 岡田元宏, 兼子直
    • Industrial Property Rights Holder
      小島俊男, 廣瀬伸一, 岡田元宏, 兼子直
    • Industrial Property Number
      2005-155133
    • Acquisition Date
      2006-12-07
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] てんかんモデル動物(CHRNA4:S284L)2005

    • Inventor(s)
      廣瀬伸一, 兼子直, 岡田元宏, 斉藤亮
    • Industrial Property Rights Holder
      廣瀬伸一, 兼子直, 岡田元宏, 斉藤亮
    • Industrial Property Number
      2004-062907
    • Acquisition Date
      2005-09-15
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] てんかんモデル動物(CHRNA4:S284L)2004

    • Inventor(s)
      廣瀬伸一, 兼子 直, 岡田元宏, 斉藤 亮
    • Industrial Property Rights Holder
      廣瀬伸一, 兼子 直, 岡田元宏, 斉藤 亮
    • Industrial Property Number
      2004-062907
    • Filing Date
      2004-03-05
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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