| Project/Area Number |
16200031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
YAMAGUCHI Takami Tohoku University, Grad.Sch.Eng., Professor, 大学院工学研究科, 教授 (30101843)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Shigeo Osaka University, Grad.Sch.Eng.Sci, Professor, 大学院基礎工学研究科, 教授 (70240546)
TSUBOTA Ken-ichi Tohoku University, Grad.Sch.Eng., Research Associate, 大学院工学研究科, 助手 (10344045)
ISHIKAWA Takuji Tohoku University, Grad.Sch.Eng., Associate Professor, 大学院工学研究科, 助教授 (20313728)
IMAI Yohsuke Tohoku University, Grad.Sch.Eng., Research Associate, 大学院工学研究科, 助手 (60431524)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
Fiscal Year 2006: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2005: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2004: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
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| Keywords | Biomechanics / Medical Engineering / Blood Flow / Thrombosis / Platelet / Red Blood Cell / Cardiovascular System / Simulation / 生物・生体工学 / 粒子法 / マイクロPIV / 血球 / 構造流体連成 |
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| Research Abstract |
We investigated multi-scale behaviors of the formation, destruction, and movement of thrombi under blood flow that are responsible for ischemia of vital organs by using computer simulation and in vitro experiments based on biomechanics. We carried out computer simulations based on a Stokesian Dynamics method and a particle method to characterize the relationships between physiological and fluid mechanical factors in platelet aggregation under blood flow. We determined the relationships between deformation of red blood cells and apparent blood flow resistance. The result indicated that interactions among blood cells play a pivotal role in blood flow properties. It was also shown that biological/mechanical interactions among different types of blood cells determine thrombogenesis process. We established an in vitro quantitative measurement of blood flow through micro channel with micro PIV system, and obtained a spatiotemporal velocity fluctuation in blood flow that depends on hemaetocrit values. This indicated that mechanical interaction among blood cells governs blood flow properties. We proposed a large-scale computer simulation model of flow of red blood cells with the Earth Simulator, and established mathematical formulae of blood flow that can explain hierarchical mechanical behaviors of blood flows from the scale of blood cells (jam) to large vessel (cm). We also developed an integrated computer model of the left ventricle and the aorta, and demonstrated that the model is practically useful in detailed evaluation of the vortex and stagnation, which greatly affects thrombogenesis, in heart and large arteries.
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