| Project/Area Number |
16203037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
OSAKA Naoyuki KYOTO UNIVERSITY, Kyoto Univ., Graduate School of Letters, Prof. (20113136)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Hidenao 高次脳機能総合研究センター, Prof. (90181297)
ASHIDA Hiroshi 京都大学, Graduate School of Letters, Assistant Prof. (20293847)
OSAKA Mariko Osaka Univ., of Foreign Studies, Dept. of Psychology, Prof. (70144300)
十河 宏行 京都大学, 産業技術総合研究所, (非常勤)研究員 (90359795)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2006: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2005: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2004: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Keywords | Working Memory / Central Executive / Prefrontal Cortex / ACC / Attention / Reading Span / 上部頭頂小葉 / 内側前頭前野 / RST / ワーキングメモリー |
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| Research Abstract |
Using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS), brain's prefrontal cortex was investigated in terms of working memory functions in human. Individual differences in working memory capacity were measured by use of reading span test both for young (graduate and undergraduate student) and elderly people (over 65). Results showed that the central executive that plays critical attentional mechanism for efficient working memory control incorporated in the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), medial prefrontal cortex (MPFC) and superior parietal lobule (SPL). These areas, working together, are highly possible to contribute efficient and adaptive processing of high-level cognition and behavior. Thus the area could be called as the central executive complex system. Specifically, we found anterior cingulated cortex (ACC) in the medial prefrontal cortex plays an important role in the processing and maintenance of ongoing verbal/spatial information. Using reading span test, we found high functional connectivity for high working memory subjects between DLPFC and ACC. This suggests that high performer's efficient working memory processing is likely based on efficient control of DLPFC-ACC executive complex.
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