| Project/Area Number |
16209062
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAGATA Toshihiko The University of Tokushima Graduate School, Institute of Health Biosciences, Professor., 大学院ヘルスバイオサイエンス研究部, 教授 (10127847)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIE Hiromasa Niigata University, Graduate School of Medical and Dental Sciences, Professor., 大学院医歯学総合研究科, 教授 (20143787)
MURAKAMI Shinya Osaka University, Graduate School of Dentistry, Professor., 大学院歯学研究科, 教授 (70239490)
TAKASHIBA Shogo Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Proffesor., 大学院医歯薬学総合研究科, 教授 (50226768)
KURIHARA Hidemi Hiroshima University, Graduate School of Biomedical Sciences, Professor., 大学院医歯薬学総合研究科, 教授 (40161765)
IZUMI Yuichi Kagoshima University, Graduate School of Medical and Dental Sciences, Professor., 大学院医歯学総合研究科, 教授 (60159803)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000)
Fiscal Year 2006: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2005: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2004: ¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
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| Keywords | periodontal diseases / gene polymorphism / disease susceptibility / aggressive periodontitis / gingival overgrowth / immunoglobulin / cytokines / invader method |
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| Research Abstract |
Polymorphism analyses using the invader method were performed (case control studies). From 12 hospitals, 622 blood samples were collected : 172 aggressive periodontitis (AgP) and the 178 controls, and 147 chronic periodontitis (CP) and the 125 controls. When AgP and the controls was compared, significant differences were detected in FcaR56T/C and MMP-3(-1171)5A/6A(-/T). When CP and the controls was compared, significant differences were detected in IL-1(+4845)G/T. In these SNPs, there were no SNPs showing both differences concerning gene distribution and allele frequencies. Further examinations are necessary to clarify these points. On the other hand, several interesting results concerning SNPs were obtained from the investigator's laboratories as follows. 1) In gingival overgrowth patients, a2 integrin +807 polymorphism was found, indicating the +807C allele is one of the genetic risk factors for drug-induced gingival overgrowth. 2) The combination of stimulatory FcyIIA and inhibitory FcyRIIB genotypes may increase susceptibility to SLE and periodontitis in the Japanese population. 3) Salivary AST, ALT and LDH levels reflect inflammation and destruction of periodontal tissue, suggesting the clinical useful markers following periodontal therapy but IL-1A+4845 alleles may not influence clinical parameters. 4) The mutant (A115V) TNSALP gene produced the defective alkaline phosphatase enzyme and it could be recessively transmitted and be a disease-causing mutation of the adult-type hypophosphatasia 5) Mannnose-binding lectin (MBL) gene mutation and smoking would be involved in the excerbation of aggressive periodontitis, via gene-environmental interaction. (229 words)
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