Development of instantaneous laser hemostasis on sheath removal hole after catheter intervention
| Project/Area Number |
16300177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Keio University |
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Principal Investigator |
ARAI Tsunenori KEIO UNIVERSITY, FACULTY OF SCIENCE AND TECHNOLOGY, Professor, 理工学部, 教授 (30338199)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥14,900,000 (Direct Cost: ¥14,900,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2004: ¥8,800,000 (Direct Cost: ¥8,800,000)
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| Keywords | laser welding / sheath removal hole / diode laser / tissue characterization / backscattering light |
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| Research Abstract |
Hemostasis method of sheath removal hole after catheter intervention should be improved to reduce patient inconvenience and doctor' s labor. I have had a idea to apply laser tissue welding technique to make above mentioned problem..
2004 financial year
I developed experimental system with porcine carotid artery pressurized by saline to study many parameters of laser tissue welding along the laser irradiation time. Diode laser (wavelength:800nm approxi.) light was irradiated through an optical fiber traveled by automatic-stage with constant speed to the artery model stained by indocyanine green. Pressure and temperature in the model were measured by a digital recorder. The best sealing was obtained when the laser power was 0.75W with 50um/s in the traveling speed. A personal computer was used as data processing and documentation.
2005 financial year
I developed experimental system with arterial pressure even when leak hole presented in the artery model. Thin angioscope was fabricated to observe intraluminal view during the sealing procedure. The sheath removal hole was sealed up to 97% of its area by adventitia welding. The temperature measurement and fluorescence measurement by the fluorospectrophotometer revealed that the mechanism of this sheath hole closure may be collagen fiber welding by laser heating.
2006 financial year
To attain stable sealing, I developed new feedback control system using light measurement at the fiber tip to arrange laser irradiation power. I developed a novel fiber tip geometry to diffuse irradiation light to the sheath hole. I conclude that bleaching measurement of indocyanine green which is correlated with received laser power can not be used for temperature monitoring of the fiber tip due to the lack accuracy
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Report
(4 results)
Research Products
(2 results)
