Effects of Asian sand dust on lung toxicity, allergy, oxidative DNA damages, and reproductive function
| Project/Area Number |
16310030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | Oita University of Nursing and Health Sciences (OUNHS) |
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Principal Investigator |
ICHINOSE T. OUNHS, Department of Health Sciences, Professor, 看護学部, 教授 (50124334)
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| Co-Investigator(Kenkyū-buntansha) |
YOSIDA S. OUNHS, Department of Health Sciences, Assistant Professor, 看護学部, 講師 (40360060)
SADAKANE K. OUNHS, Department of Health Sciences, Assistant, 看護学部, 助教 (20322381)
HIRAKU Y. Mie University Graduate School of Medicine, Department of Environmental and Molecular Medicine, Assistant Professor, 医学部・衛生学教室, 講師 (30324510)
TAKAO H. National Institute for Environmental Studies, Environmental Health Sciences Division, Director, 病態生理研究, 領域長 (60281698)
NISHIKAWA M. National Institute for Environmental Studies, Laboratory for Intellectual Fundamentals for Environmental Studies, Team Director, 環境分析科学, 室長 (80228171)
川西 正祐 三重大学, 医学部・衛生学教室, 教授 (10025637)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,700,000 (Direct Cost: ¥15,700,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2004: ¥7,800,000 (Direct Cost: ¥7,800,000)
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| Keywords | Asian Sand dust / Allergy / Oxidative DNA damages / Reproductive function / Murine lung / Bronchial asthma / IgE production / Mineral dust |
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| Research Abstract |
A recent study has shown that Asian dust (AD) events are associated with an increase in daily mortality, and caused cardiovascular and respiratory problems in Seoul, Korea. Here, we report the danger of wind-borne AD on pulmonary and male reproductive system. ICR mice were instilled intratracheally with Asian dust. We found that inflammatory lung injury and DNA damages (8-oxo-dG production) were induced by Asian dust with Cl^-, SO_4^<2->, NO_3 and microbiological materials, such as lipopolysaccharide (LPS), and beta-glucans. We examined the effects of Asian dusts toward allergic airway inflammation induced by antigen. AD induced the adjuvant effects to specific IgE and IgG1 production in serum by antigens. AD caused the aggravating effect on antigen-associated eosinophilic lung inflammation, which may be due mainly to the microbial materials and silica contained in AD. AD also caused the aggravating effect on Japanese cender pollen-associated allergic rhinitis in guinea pigs. Atmospheric exposure to molds, bacteria and silica-carrying AD may affect human health directly through allergic induction of respiratory stress. We also investigated the effects of AD on male reproductive system of mice. We found that AD has adverse effects on mouse male reproductive function, such as spermatogenesis. Our data suggest that AD may potentially influence spermatogenesis in men.
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Report
(4 results)
Research Products
(3 results)
