Development of Oxidative Stability and Bioavailability of Fatty Nutraceuticals Using Single Dispersed Micro/Nanosphere

• Project/Area Number: 16380082
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: MIYASHITA Kazuo Hokkaido University, Faculty of Fisheries Sciences, Professor, 大学院水産科学研究院, 教授 (10182015)
• Co-Investigator(Kenkyū-buntansha): HOSOKAWA Masashi Hokkaido University, Faculty of Fisheries Sciences, Associate Professor, 大学院水産科学研究院, 助教授 (10241374)
• Project Period (FY): 2004 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥15,600,000); Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000); Fiscal Year 2005: ¥4,300,000 (Direct Cost: ¥4,300,000); Fiscal Year 2004: ¥7,000,000 (Direct Cost: ¥7,000,000)
• Keywords: Micro / Nanosphere / Functional lipids / DHA / EPA / Prevention of oxidation / Interface / Nano-emulsion / Stereochemical configuration / Particle size

Research Abstract

1.The oxidative stability of EPA and DHA in aqueous solutions was dramatically different from that in bulk phase. When the oxidative stabilities of six types of typical PUFA were compared in micelles, LA was the most susceptible to oxidation. In contrast, DHA and EPA were very stable. Oxidative stability of EPA and DHA in emulsion depended on the particle size and the interface. With decreasing particle size the stability of DHA and EPA increased. The reverse result was obtained in the oxidation of linoleate.
2.The oxidative stability of lipids in emulsion is strongly affected by altering the droplet size and the packing of the emulsifier and lipid molecules at the interface. Oxidative stability was compared among TGs dispersed with three kinds of sucrose esters having the same fatty acyl composition, the stability increased with increasing their hydrophile-lipophile balance (HLB) in both TGs, although these emulsifiers had no effect on the oxidative stability of SoyTG and DHATG in bulk phase.
3.Antioxidant activity also depended on the interface. With increasing the concentration of antioxidatns in interface layer the stability of lipids increased.
4.Micro/nanosphere containing functional lipid compounds can be stabilized by the regulation of interface. Moreover, it would be more acceptable to biological systems than other forms.

Research Products

• [Journal Article] Occurrence of conjugated linolenic acids in purified soybean oil. (2007)
  • Author(s): Kinami, T., Horii, N., Narayan, B., Arato, S., Hosokawa, M., Miyashita, K., Negishi, H., Ikuina, J., Noda, R., Shirasawa, S.
  • Journal Title: J. Am. Oil Chem. Soc. 84 Pages: 23-29
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Oxidative stability of salmon and herring roe lipids and their dietary effect on plasma cholesterol levels of rats. (2007)
  • Author(s): Moriya, H., Kuniminato, T., Hosokawa, M., Fukunaga, K., Nishiyama, T., Miyashita, K.
  • Journal Title: Fisheries Sci. (印刷中)
  • NAID: 10018761913
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Catalpa seed oil rich in 9t, 11t, 13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats. (2006)
  • Author(s): Suzuki, R., Yasui, Y., Kohno, H., Miyamoto, S., Hosokawa, M., Miyashita.K., Tanaka, T.
  • Journal Title: Oncology Re. 16 Pages: 989-996
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A_2. (2006)
  • Author(s): Yamamoto, Y., Hosokawa, M., Miyashita, K.
  • Journal Title: J. Mole. Cata. B : Enzymatic 41 Pages: 92-96
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. (2006)
  • Author(s): Beppu, F., Hosokawa, M., Tanaka, L., Miyashita, K.
  • Journal Title: J. Nutri. Biochem. 17 Pages: 830-836
  • NAID: 120000967720
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fucoxanthin and its metabolite, fucoxanthinol, suppress sdipocyte differentiation in 3T3-Ll cells. (2006)
  • Author(s): Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K.
  • Journal Title: Int. J. Mole. Med. 18 Pages: 147-152
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 水産脂質の水系での酸化安定性. (2006)
  • Author(s): 宮下和夫
  • Journal Title: 日本水産学会誌 72 Pages: 636-639
  • NAID: 110004818341
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 水系での不飽和脂質の酸化安定性に関する研究. (2006)
  • Author(s): 宮下和夫
  • Journal Title: オレオサイエンス 6 Pages: 585-591
  • NAID: 130004650787
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats. (2006)
  • Author(s): Suzuki, R., Yasui, Y., Kohno, H., Miyamoto, S., Hosokawa, M., Miyashita, K., Tanaka, T.
  • Journal Title: Oncology Re. 16 Pages: 989-996
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A_2. (2006)
  • Author(s): Yamamoto, Y., Hosokawa, M., Miyashita, K.
  • Journal Title: J.Mole.Cata.B : Enzymatic 41 Pages: 92-96
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells. (2006)
  • Author(s): Beppu, R, Hosokawa, M., Tanaka, L., Miyashita, K.
  • Journal Title: J.Nutri.Biochem. 17 Pages: 830-836
  • NAID: 120000967720
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fucoxanthin and its metabolite, fucoxanthinol, suppress sdipocyte differentiation in 3T3-L1 cells. (2006)
  • Author(s): Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K.
  • Journal Title: Int.J.Mole.Med. 18 Pages: 147-152
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Study on the oxidative stability of polyunsaturated fatty acids in aqueous systems. (2006)
  • Author(s): Miyashita, K.
  • Journal Title: Oleo Sci. 6 Pages: 585-591
  • NAID: 130004650787
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Oxidative stability of marine lipids in aqueous systems. (2006)
  • Author(s): Miyashita, K.
  • Journal Title: Nippon Suisan Gakkaishi 720 Pages: 636-639
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] "Occurrence of conjugated fatty acids in aquatic and terrestrial plants and their physiological effects" In : Nutraceutical and Specialty Lipids and Their Co-Products (Shahidi, F. ed.) (2006)
  • Author(s): Narayan, B., Hosokawa, M., Miyashita, K.
  • Journal Title: CRC Taylor ＆ Francis, New York Pages: 201-218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potent inhibitory effect of trans9, transll isomer of conjugated linoleic acid on the growth of human colon cancer cells. (2006)
  • Author(s): Beppu, F., Hosokawa, M., Tanaka, L., Miyashita, K.
  • Journal Title: J. Nutri. Biochem. 17 Pages: 830-836
• [Journal Article] Fucoxanthin and its metabolite, fucoxanthinol, suppress sdipocyte differentiation in 3T3-L1 cells. (2006)
  • Author(s): Maeda, H., Hosokawa, M., Sashima, T., Takahashi, N., Kawada, T., Miyashita, K.
  • Journal Title: Int. J. Mole. Med. 18 Pages: 147-152
• [Journal Article] 水系での不飽和脂質の酸化安定牲に関する研究. (2006)
  • Author(s): 宮下和夫
  • Journal Title: オレオサイエンス 6 Pages: 585-591
• [Journal Article] Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme (2005)
  • Author(s): Ono S, Hosokawa M, Miyashita K, Takahashi K
  • Journal Title: Int. J. Food Sci. Tech. 40 Pages: 1-4
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo (2005)
  • Author(s): Shiratori K, Ohgami K, Ilieva I, X.-H.Jin X-H, Koyama Y, Miyashita K, Yoshida K, Kase S, Ohno S
  • Journal Title: Exp. Eye Res. 81 Pages: 422-428
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues (2005)
  • Author(s): Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K
  • Journal Title: Biochem. Biophys. Res. Comm. 332 Pages: 392-397
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression (2005)
  • Author(s): Ishigamori H, Hosokawa M, Kohno H, Tanaka T, Miyashita K, Takahashi K
  • Journal Title: Mole. Cell. Biochem. 275 Pages: 127-133
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bitter gourd seed fatty acid rich in 9c, 11t, 13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells (2005)
  • Author(s): Yasui Y, Hosokawa M, Sahara T, Suzuki R, Ohgiya S, Kohno H, Tanaka T, Miyashita K
  • Journal Title: Prostag. Leukotr. Ess. 73 Pages: 113-119
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid (2005)
  • Author(s): Araseki, M, Kobayashi H, Hosokawa M, Miyashita K
  • Journal Title: Biosci. Biotechnol. Biochem. 69 Pages: 483-490
  • NAID: 10016640520
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. (2005)
  • Author(s): Ono, S., Hosokawa, M., Miyashita, K., Takahashi, K.
  • Journal Title: Int.J.Food Sci.Tech. 40 Pages: 1-4
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. (2005)
  • Author(s): Shiratori, K., Ohgami, K., Ilieva, I., Jin.X.-H., Koyama, Y., Miyashita, K., Yoshida, K., Kase, S., Ohno, S.
  • Journal Title: Exp.Eye Res. 81 Pages: 422-428
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. (2005)
  • Author(s): Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., Miyashita, K.
  • Journal Title: Biochem.Biophys.Res.Comm. 332 Pages: 392-397
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. (2005)
  • Author(s): Ishigamori, H., Hosokawa, M., Kohno, H., Tanaka, T., Miyashita, K., Takahashi, K.
  • Journal Title: Mole.Cell.Biochem. 275 Pages: 127-133
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bitter gourd seed fatty acid rich it 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells. (2005)
  • Author(s): Yasui, Y., Hosokawa, M., Sahara, T., Suzuki, R., Ohgiya, S., Kohno, H., Tanaka, T., Miyashita, K.
  • Journal Title: Prostag.Leukotr.Ess. 73 Pages: 113-119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid. (2005)
  • Author(s): Araseki, M., Kobayashi, H., Hosokawa, M., Miyashita, K.
  • Journal Title: Biosci.Biotechnol.Biochem. 69 Pages: 483-490
  • NAID: 10016640520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme (2005)
  • Author(s): Ono S, Hosokawa M, Miyashita K, Takahashi K.
  • Journal Title: Int.J.Food Sci.Tech. 40 Pages: 1-4
• [Journal Article] Effects of fucoxanthin on Iipopolysaccharide-induced inflammation in vitro in vivo (2005)
  • Author(s): Siratori K, Ohgami K, Ilieva I, X.-H.Jin X-H, Koyama Y, Miyashita K, Yoshida K, Kase S, Ohno S.
  • Journal Title: Exp.Eye Res. 81 Pages: 422-428
• [Journal Article] Fucoxanthin from edible seaweed, Undariapinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues (2005)
  • Author(s): Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K.
  • Journal Title: Biochem.Biophys.Res.Comm 332 Pages: 392-397
• [Journal Article] Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression (2005)
  • Author(s): Ishigamori H, Hosokawa M, Kohno H, Tanaka T, Miyashito K, Takahashi K.
  • Journal Title: Mole.Cell.Biochem. 275 Pages: 127-133
• [Journal Article] Bitter gourd seed fatty acid rich in 9c, 11t, 13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells (2005)
  • Author(s): Yasui Y, HosoKawa M, sSahara T, Suzuki R, Ohgiya S, Kohno H, Tanaka T, Miyashita K.
  • Journal Title: Prostag.Leukotr.Ess 73 Pages: 113-119
• [Journal Article] Lipid per oxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid (2005)
  • Author(s): Araseki, M, Kobayashi H, Hosokawa M, Miyashita K.
  • Journal Title: Biosci.Biotechnol.Biochem. 69 Pages: 483-490
  • NAID: 10016640520
• [Journal Article] Proton NMR relaxation times of polyunsaturated fatty acids in chloroform solutions and aqueous micelles. (2004)
  • Author(s): Kobayashi, H., Yoshida, M., Maeda, I., Miyashita, K.
  • Journal Title: J. Oleo Sci. 56 Pages: 105-108
  • NAID: 10012104242
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. (2004)
  • Author(s): Kohno, H., Suzuki, R., Yasui, Y., Hosokawa, M., Miyashita, K., Tanaka, T.
  • Journal Title: Cancer Sci. 95 Pages: 481-486
  • NAID: 10013723418
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparative study on the autoxidation of TAG containing conjugated and nonconjugated C18 PUFA. (2004)
  • Author(s): Suzuki, R., Abe, M., Miyashita, K.
  • Journal Title: J. Am. Oil Chem. Soc. 81 Pages: 563-569
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARy expression and alteration of lipid composition. (2004)
  • Author(s): Kohno, H., Yasui, Y., Suzuki, R., Hosokawa, M., Miyashita, K., Tanaka, T.
  • Journal Title: Int. J. Cancer 110 Pages: 896-901
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Saparartion of sardine oil without heating from surimi waste and its effect on lipid metabolism in rats. (2004)
  • Author(s): Toyoshima, K., Noguchi, R., Hosokawa, M., Fukunaga, K., Nishiyama, T., Takahashi, R., Miyashita, K.
  • Journal Title: J. Agric. Food Chem. 52 Pages: 2372-2375
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bacterial microflora of carp (Cyprius carpio) and its shelf-life extension by essential oil compounds. (2004)
  • Author(s): Mahmoud, B.S.M., Yamazaki, K., Miyashita, K., Shin, I.-S., Chang, D.-S., Suzuki, T.
  • Journal Title: Food Micro. 21 Pages: 657-666
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Decontamination effect of electrolyzed NaCl solutions on carp. (2004)
  • Author(s): Mahmoud, B.S.M., Yamazaki, K., Miyashita, K., Shin, I.-S., Chang, D.-S., Suzuki, T.
  • Journal Title: Lett. Appl. Micro. 39 Pages: 169-173
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells. (2004)
  • Author(s): Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., Myashita, K.
  • Journal Title: Biochim. Biophys. Acta 1675 Pages: 113-119
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] O/Wエマルションの界面化学特性と脂質酸化. (2004)
  • Author(s): 宮下和夫
  • Journal Title: FFIジャーナル 209 Pages: 947-953
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of flexibility and permeability of polyunsaturated fatty acid molecules on their oxidative stability in aqueous systems. (2004)
  • Author(s): Miyashita, K.
  • Journal Title: Lipid Technology Newsletter 16 Pages: 197-202
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Proton NMR relaxation times of polyunsaturated fatty acids in chloroform solutions and aqueous micelles. (2004)
  • Author(s): Kobayashi, H., Yoshida, M., Maeda, I., Miyashita, K.
  • Journal Title: J.Oleo Sci. 56 Pages: 105-108
  • NAID: 10012104242
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative study on the autoxidation of TAG containing conjugated and nonconjugated C18 PUFA. (2004)
  • Author(s): Suzuki, R., Abe, M., Miyashita, K.
  • Journal Title: J Am.Oil Chem.Soc. 81 Pages: 563-569
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARD expression and alteration of lipid composition. (2004)
  • Author(s): Kohno, H., Yasui, Y., Suzuki, R., Hosokawa, M., Miyashita, K., Tanaka, T.
  • Journal Title: Int.J.Cancer 110 Pages: 896-901
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Separation of sardine oil without heating from surimi waste and its effect on lipid metabolism in rats. (2004)
  • Author(s): Toyoshima, K., Noguchi, R., Hosokawa, M., Fukunaga, K., Nishiyama, T., Takahashi, R., Miyashita, K.
  • Journal Title: J.Agric.Food Chem. 52 Pages: 2372-2375
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Decontamination effect of electrolyzed NaC1 solutions on carp. (2004)
  • Author(s): Mahmoud, B.S.M., Yamazaki, K., Miyashita, K.Shin, I.-S., Chang, D.-S., Suzuki, T.
  • Journal Title: Lett.Appl.Micro. 39 Pages: 169-173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells. (2004)
  • Author(s): Hosokawa, M., Kudo, M., Maeda, H., Kohno, H., Tanaka, T., Miyashita, K.
  • Journal Title: Biochim.Biophys.Acta 1675 Pages: 113-119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of chemical properties of oil in water emulsion on lipid peroxidation. (2004)
  • Author(s): Miyashita, K.
  • Journal Title: Foods ＆ Food Ingredients Journal of Japan 209 Pages: 947-954
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative Study on the Autoxidation of TAG Containing Conjugated and Non-conjugated C18 Polyunsaturated Fatty Acids (2004)
  • Author(s): R.Suzuki, M.Abe, K.Miyashita
  • Journal Title: J.Am.Oil Chem.Soc. 81 Pages: 563-569
• [Journal Article] Occurrence of Conjugated Polyenoic Fatty Acids in Seaweeds from the Indian Ocean (2004)
  • Author(s): B.Narayan, T.Kinami, K.Miyashita, Si.-B.Park, Y.Endo, K.Fujimoto
  • Journal Title: Zeitschrift fur Naturforschung 59C Pages: 310-314
• [Journal Article] Proton NMR Relaxation Time of Polyunsaturated Fatty Acids in Chloroform Solutions and Aqueous Micelles (2004)
  • Author(s): H.Kobayashi, M.Yoshida, I.Maeda, K.Miyashita
  • Journal Title: J.Oleo Sci. 56 Pages: 105-108
  • NAID: 10012104242
• [Journal Article] Fucoxanthin Induces Apoptosis and Enhances the Antiproliferative Effect of the PPAR-γ Ligand, troglitazone, on colon cancer cells (2004)
  • Author(s): M.Hosokawa, M.Kudo, H.Maeda, H.Kohno, T.Tanaka, K.Miyashita
  • Journal Title: Biochim.Biophys.Acta 1675 Pages: 113-119
• [Journal Article] O/Wエマルションの界面化学特性と脂質酸化 (2004)
  • Author(s): 宮下和夫
  • Journal Title: FFIジャーナル 209 Pages: 947-953
• [Journal Article] Effects of Flexibility and Permeability of Polyunsaturated Fatty Acid Molecules on Their Oxidative Stability in Aqueous Systems (2004)
  • Author(s): K.Miyashita
  • Journal Title: Lipid Technology Newsletter 16 Pages: 197-202
• [Journal Article] Oxidative stability of salmon and herring roe lipids and their dietary effect on plasma cholesterol levels of rats.
  • Author(s): Moriya, H., Kuniminato, T., Hosokawa, M., Fukunaga, K., Nishiyama, T., Miyashita, K.
  • Journal Title: Fosheries Sci. (in press)
  • NAID: 10018761913
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] "Occurrence of conjugated fatty acids in aquatic and terrestrial plants and their physiological effects" In : Nutraceutical and Specialty Lipids and Their Co-Products (2006)
  • Author(s): Narayan, B., Hosokawa, M., Miyashita, K.
  • Total Pages: 19
  • Publisher: CRC Taylor ＆ Francis, New York
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 酸化防止「油脂・脂質の基礎と応用」 (2005)
  • Author(s): 宮下和夫
  • Total Pages: 276
  • Publisher: 日本油化学会
• [Book] 酸化防止.「水産機能性脂質-給源・機能・利用-」 (2004)
  • Author(s): 宮下和夫
  • Total Pages: 9
  • Publisher: 恒星社厚生閣
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 酸化防止.「油脂・脂質の基礎と応用」 (2004)
  • Author(s): 宮下和夫
  • Total Pages: 6
  • Publisher: 日本油化学会
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 酸化防止(水産学シリーズ:水産機能性脂質;高橋是太郎編) (2004)
  • Author(s): 宮下和夫
  • Total Pages: 179
  • Publisher: 恒星社厚生閣