PhYsiological function of focal adiesion protein vinexin

• Project/Area Number: 16380229
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied molecular and cellular biology
• Research Institution: Kyoto University
• Principal Investigator: KIOKA Noriyuki Kyoto University, Division of Applied life Sciences, Associate Professor (90234179)
• Co-Investigator(Kenkyū-buntansha): YAMADA Masayasu Kyoin University, Division of Biosciences, Associate Professor (10243073) ; UEDA Kazumitsu Kyoto University, Institute for Integrated Cell-Material Sriences(iCeMS), Professor (10151789)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥16,290,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥690,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000); Fiscal Year 2005: ¥4,200,000 (Direct Cost: ¥4,200,000); Fiscal Year 2004: ¥4,900,000 (Direct Cost: ¥4,900,000)
• Keywords: Cell Adhesion / Wound healing / Tumorigenesis / Migration / Signal transduction / がん / 再生医学 / ビネキシン / 細胞骨格 / 分化 / アクチン / 浸潤 / 足場依存性

Research Abstract

Cell migration play important roles in various physiological and pathophysiological conditions, including wound healing, angiogenesis, and tumor invasion. Clarifying the mechanisms of cell migration can contribute to the development of new anti-cancer or anti-metastasis drugs. This research has investigated the function of a novel focal adhesion protein, vinexin, in wound healings, cell migration, and signal transduction,using vinexin-knock out mice and knockdown cells.
1) Wound healing-We found that gene disruption of vinexin induces the delayed wound healing of cutaneous injury. Knockdown of vinexin expression in cultured keratinocytes showed that vinexin regulate wound healing through regulating the activation and localization of EGRR
2) Anchorage-dependence of signaling-Mechanisms of regulating anchorage-independent activation of ERK by vinexin was examined. We found that vinexin inhibits the inactivation of ERK. We also showed that anchorage-dependent regulation of ERK activation depends on the inactivation process in part.
3) Roles in the regulation of cytoskeleton and spreading-Knockdown of vinexin expression in Highly invasive HT1080 cells showed that vinexin has roles in cell spreading through the control of a small G-protein activation. We also found that vinexin directly associates with WAVE2, a downstream factor of the small G protein, and regulates its phosphorylation and amount.

Research Products

• [Journal Article] Abl kinase interacts with and phosphorylates vinexin (2008)
  • Author(s): Mitsushima, M., H. Takahashi, T. Shishido, K. Ueda, and N. Kioka
  • Journal Title: FEBS Lett 580 Pages: 4288-4295
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation (2007)
  • Author(s): Mitsushima, M., K. Ueda, and N. Kioka.
  • Journal Title: Exp Cell Res 313 Pages: 1830-1838
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. (2007)
  • Author(s): Kimura, Y., N. Kioka, H. Kato, M. Matsuo, and K. Ueda.
  • Journal Title: Biochem J 401 Pages: 597-605
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingom yelin-deficient Chinese hamster ovary cells. (2007)
  • Author(s): Nagao, K., K. Takahashi, K. Hanada, N. Kioka, M. Matsuo, and K. Ueda.
  • Journal Title: J Biol Chem 282 Pages: 14868-14874
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4. (2007)
  • Author(s): Morita, S. Y., A. Kobayashi, Y. Takanezawa, N. Kioka, T. Handa, H. Arai, M. Matsuo, and K. Ueda
  • Journal Title: Hepatology 46 Pages: 188-199
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ビンキュリン活性化を取り巻くタンパク質間相互作用 (2007)
  • Author(s): 木岡紀幸
  • Journal Title: 生体の科学 58 Pages: 430-431
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Modulation of drug-stimulated ATPase activity of human MDRUP-glycoprotein by cholesterol. (2007)
  • Author(s): Kimura, Y., N., Kioka, H., Kato, M., Matsuo, K., Ueda
  • Journal Title: Biochem J 401 Pages: 597-605
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation. (2007)
  • Author(s): Mitsushima, M., K., Ueda, N., Kioka
  • Journal Title: Exp Cell Res 313 Pages: 1830-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4. (2007)
  • Author(s): Morita, S., Y., A., Kobayashi, Y., Takanezawa, N., Kioka, T., Handa, H., Arai, M., Matsuo, K., Ueda
  • Journal Title: Hepatology 46 Pages: 188-99
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells. (2007)
  • Author(s): Nagao, K., K., Takahashi, K., Hanada, N., Kioka, M., Matsuo, K., Ueda
  • Journal Title: J Biol Chem 282 Pages: 14868-74
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein-protein interaction regulating vinculin activation. (2007)
  • Author(s): Kioka, N
  • Journal Title: Seitai-no-Kagaku 58 Pages: 430-431
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of phosphatases in the anchorgage-dependent regulation of ERK2 activation (2007)
  • Author(s): Mitsushima, M., K. Ueda, and N. Kioka.
  • Journal Title: Exp Cell Res 313 Pages: 1830-1838
  • Peer Reviewed
• [Journal Article] Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary (2007)
  • Author(s): Nagao, K., K. Takahashi, K. Hanada, N. Kioka, M. Matsuo, and K. Ueda.
  • Journal Title: J Biol Chem 287 Pages: 14868-14874
  • Peer Reviewed
• [Journal Article] INVOLVEMENT OF PHOSPHATASES IN THE ANCHORAGE-DEPENDENT REGULATION OF ERK2 ACTIVATION. (2007)
  • Author(s): Mitsushima, M., K.Ueda, N.Kioka.
  • Journal Title: Exp Cell Res (in press)
• [Journal Article] Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. (2007)
  • Author(s): Kimura, Y., N.Kioka, H.Kato, M.Matsuo, K.Ueda.
  • Journal Title: Biochem J 401 Pages: 597-605
• [Journal Article] Purification and ATPase activity of human ABCAl (2007)
  • Author(s): Takahashi, K., Y.Kimura, N.Kioka, M.Matsuo, K.Ueda
  • Journal Title: J Biol Chem 281 Pages: 10760-10768
• [Journal Article] Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. (2006)
  • Author(s): Mitsushima, M., T. Sezaki, R. Akahane, K. Ueda, S. Suetsugu, T. Takenawa, and N. Kioka
  • Journal Title: Genes Cells 11 Pages: 281-292
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. (2006)
  • Author(s): Mitsushima, M., K. Ueda, and N. Kioka
  • Journal Title: Genes Cells 11 Pages: 971-982
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Purification and ATPase activity of human ABCA1 (2006)
  • Author(s): Takahashi, K., Y. Kimura, N. Kioka, M. Matsuo, and K. Ueda
  • Journal Title: J Biol Chem 281 Pages: 10760-10768
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 (2006)
  • Author(s): Kobayashi, A., Y. Takanezawa, T. Hirata, Y. Shimizu, K. Misasa, N. Kioka, H. Arai, K. Ueda, and M. Matsuo.
  • Journal Title: J Lipid Res 47 Pages: 791-802
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 細胞-細胞外基質間接着-インテグリン裏打ちタンパク質による接着構造のターンオーバーと運動の制御. (2006)
  • Author(s): 木岡紀幸, 満島勝, 高橋穂波, 植田和光
  • Journal Title: 実験医学 24 Pages: 1991-1997
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. (2006)
  • Author(s): Kobayashi, A., Y., Takanezawa, T., Hirata, Y., Shimizu, K., Misasa, N., Kioka, H., Arai, K., Ueda, M., Matsuo
  • Journal Title: J Lipid Res 47 Pages: 791-802
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. (2006)
  • Author(s): Mitsushima, M., T., Sezaki, R., Akahane, K., Ueda, S., Suetsugu, T., Takenawa, N., Kioka
  • Journal Title: Genes Cells 11 Pages: 281-92
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Abl kinase interacts with and phosphorylates vinexin. (2006)
  • Author(s): Mitsushima, M., H., Takahashi, T., Shishido, K., Ueda, N., Kioka
  • Journal Title: FEBS Lett 580 Pages: 4288-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. (2006)
  • Author(s): Mitsushima, M., K., Ueda, N., Kioka
  • Journal Title: Genes Cells 11 Pages: 971-82
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Purification and ATPase activity of human ABCA1. (2006)
  • Author(s): Takahashi, K., Y., Kimura, N., Kioka, M. Matsuo, K., Ueda
  • Journal Title: J Biol Chem 281 Pages: 10760-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of cell migration and turn over of focal adhesion by integrin associated proteins. (2006)
  • Author(s): Kioka, N., Mitsushima, M., Takahashi, H., Ueda, K
  • Journal Title: Jikken Igaku 24 Pages: 1991-1997
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. (2006)
  • Author(s): Mitsushima, M., T.Sezaki, R.Akahane, K.Ueda, S.Suetsugu, T.Takenawa, N.Kioka
  • Journal Title: Genes Cells 11 Pages: 281-292
• [Journal Article] Abl kinase interacts with and phosphorylates vinexin (2006)
  • Author(s): Mitsushima, M., H.Takahashi, T.Shishido, K.Ueda, N.Kioka
  • Journal Title: FEBS Lett 580 Pages: 4288-4295
• [Journal Article] Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. (2006)
  • Author(s): Mitsushima, M., K.Ueda, N.Kioka
  • Journal Title: Genes Cells 11 Pages: 971-982
• [Journal Article] Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin (2006)
  • Author(s): Mitsushima M, Sezaki T, Akahane R, Ueda K, Suetsugu S, Takenawa T, Kioka N
  • Journal Title: Genes Cells 11 Pages: 281-292
• [Journal Article] Spatial distribution and functional significance of activated vinculin in living cells (2005)
  • Author(s): Chen H, Cohen DM, Choudhury DM, Kioka N, Craig SW
  • Journal Title: J Cell Biol 169 Pages: 459-470
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SHIP2 interaction with the cytoskeletal protein Vinexin (2005)
  • Author(s): Paternotte N, Zhang J, Vandenbroere I, Backers K, Blero D, Kioka N, Vanderwinden JM, Pirson I, Erneux C
  • Journal Title: FEBS J 272 Pages: 6052-6066
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of interaction with vinculin in recruitment of vinexins to focal adhesions (2005)
  • Author(s): Takahashi H, Mitsushima M, Okada N, Ito T, Aizawa S, Akahane R, Umemoto T, Ueda K, Kioka N
  • Journal Title: Biochem Biophys Res Commun 336 Pages: 239-246
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Detection of ABCA7-positive cells in salivary glands from patients with Sjogren's syndrome (2005)
  • Author(s): Toda Y, Aoki R, Ikeda Y, Azuma Y, Kioka N, Matsuo M, Sakamoto M, Mori S, Fukumoto M, Ueda K
  • Journal Title: Pathol Int 55 Pages: 639-643
  • NAID: 10017125838
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Spatial distribution and functional significance of activated vinculin in living cells. (2005)
  • Author(s): Chen, H., D., M., Cohen, D., M., Choudhury, N., Kioka, S., W., Craig
  • Journal Title: J Cell Biol 169 Pages: 459-70
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SHIP2 interaction with the cytoskeletal protein Vinexin. (2005)
  • Author(s): Paternotte, N., J., Zhang, I., Vandenbroere, K., Backers, D., Blero, N., Kioka, J., M., Vanderwinden, I., Pirson, C., Erneux
  • Journal Title: Febs J 272 Pages: 6052-66
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of interaction with vinculin in recruitment of vinexins to focal adhesions. (2005)
  • Author(s): Takahashi, H., M., Mitsushima, N., Okada, T., Ito, S., Aizawa, R., Akahane, T., Umemoto, K., Ueda, N., Kioka
  • Journal Title: Biochem Biophys Res Commun 336 Pages: 239-46
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Detection of ABCA7-positive cells in salivary glands from patients with Sjogren's syndrome. (2005)
  • Author(s): Toda, Y., R., Aoki, Y., Ikeda, Y., Azunia, N., Kioka, M., Matsuo, M., Sakamoto, S., Mori, M., Fukumoto, K., Ueda
  • Journal Title: Pathol Int 55 Pages: 639-43
  • NAID: 10017125838
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Extracellular Signal-regulated Kinase Activated by Epidermal Growth Factor and Cell Adhesion Interacts with and Phosphorylates Vinexin. (2004)
  • Author(s): Mitsushima, M., Suwa, A., Amachi, T., Ueda, K. and Kioka, N.
  • Journal Title: J Biol Chem 279 Pages: 34570-34577
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Alphal-syntrophin modulates turnover of ABCA1 (2004)
  • Author(s): Munehira, Y., Ohnishi, T., Kawamoto, S., Furuya, A., Shitara, K., Imamura, M., Yokota, T., Takeda, S., Amachi, T., Matsuo, M., Kioka, N. and Ueda, K.:
  • Journal Title: J Biol Chem 279 Pages: 15091-15095
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein. (2004)
  • Author(s): Kimura, Y., Matsuo, M., Takahashi, K., Saeki, T., Kioka, N., Amachi, T. and Ueda, K
  • Journal Title: Drug Metab 5 Pages: 1-10
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles (2004)
  • Author(s): Nagata, K., Yamamoto, A., Ban, N., Tanaka, A. R., Matsuo, M., Kioka, N., Inagaki, N. and Ueda, K.
  • Journal Title: Biochem Biophys Res Commun 324 Pages: 262-268
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ATP hydrolysis-dependent multidrug efflux transporter : MDR1/P-glycoprotein. (2004)
  • Author(s): Kimura, Y., M., Matsuo, K., Takahashi, T., Saeki, N., Kioka, T., Amachi, K., Ueda
  • Journal Title: Curr Drug Metab 5 Pages: 1-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Extracellular Signal-regulated Kinase Activated by Epidermal Growth Factor and Cell Adhesion Interacts with and Phosphorylates Vinexin. (2004)
  • Author(s): Mitsushima, M., A., Suwa, T., Amachi, K., Ueda, N., Kioka
  • Journal Title: J Biol Chem 279 Pages: 34570-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alpha1-syntrophin modulates turnover of ABCA1. (2004)
  • Author(s): Munehira, Y., T., Ohnishi, S., Kawamoto, A., Furuya, K., Shitara, M., Imamura, T., Yokota, S., Takeda, T., Amachi, M., Matsuo, N., Kioka, K., Ueda
  • Journal Title: J Biol Chem 279 Pages: 15091-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles. (2004)
  • Author(s): Nagata, K., A., Yamamoto, N., Ban, A., R., Tanaka ; M., Matsuo, N., Kioka, N., Inagaki, K., Ueda
  • Journal Title: Biochem Biophys Res Commun 324 Pages: 262-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Extracellular Signal-regulated Kinase Activated by Epidermal Growth Factor and Cell Adhesion Interacts with and Phosphorylates Vinexin. (2004)
  • Author(s): Mitsushima, M., Suwa, A., Amachi T., Ueda, K., Kioka, N.
  • Journal Title: J Biol Chem 279 Pages: 34570-34577
• [Journal Article] Alpha1-syntrophin modulates turnover of ABCA1 (2004)
  • Author(s): Munehira, Y., Ohnishi, T., Kawamoto, S., Furuya, A., Shitara, K., Imamura, M., Yokota, T., Takeda, S., Amachi, T., Matsuo, M., Kioka, N., Ueda, K.
  • Journal Title: J Biol Chem 279 Pages: 15091-15095
• [Journal Article] ATP hydrolysis-dependent multidrug efflux transporter : MDR1/P-glycoprotein. (2004)
  • Author(s): Kimura, Y., Matsuo, M., Takahashi, K., Saeki, T., Kioka, N., Amachi, T., Ueda, K
  • Journal Title: Drug Metab 5 Pages: 1-10
• [Journal Article] Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles (2004)
  • Author(s): Nagata, K., Yamamoto, A., Ban, N., Tanaka, A.R., Matsuo, M., Kioka, N., Inagaki, N., Ueda, K.
  • Journal Title: Biochem Biophys Res Commun 324 Pages: 262-268
• [Presentation] Loss of vinexin expression impairs the wound healing in vitro and in vivo. (2007)
  • Author(s): N. Kioka, T. Itoh, T. Umemoto, N. Uekawa, M. Yamada, H. Imai, K. Ueda
  • Organizer: 47th Annual Meeting of American Sciety of Cell Biology
  • Place of Presentation: Washington DC, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] V-Src Suppresses the Expression but Stimulates Tyrosine Phosphorylation of Vinexin (2007)
  • Author(s): T. Umemoto, K. Tanaka, M. Mitsushima, K. Ueda, and N. Kioka
  • Organizer: 47th Annual Meeting of American Sciety of Cell Biology
  • Place of Presentation: Washington DC, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ueda Loss of vinexin expression impairs the wound healing in vitro and in vivo (2007)
  • Author(s): N., Kioka, T., Itoh, T., Umemoto, N., Uekawa, M., Yamada, H., Imai, K
  • Organizer: 47th ASCB Annual Meeting I
  • Place of Presentation: Washingto DC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] V-Src Suppresses the Expression but Stimulates Tyrosine Phosphorylation of Vinexin (2007)
  • Author(s): T., Umemoto, K., Tanaka, M., Mitsushima, K., Ueda, N., Kioka
  • Organizer: 47th ASCB Annual Meeting I
  • Place of Presentation: Washingto DC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Loss of vinexin expression impairs the wound healing in vitro and in vivo. (2007)
  • Author(s): N. Kioka, T. Itoh, T. Umemoto, N. Uekawa, M. Yamada, H. Imai, K.
  • Organizer: 47th Annual Meeting of American Sciety of Cell Biology
  • Place of Presentation: Washington DC, USA Washington Convention Center
• [Presentation] Vinexin a Promotes the Association of Vinculin with Cytoskeleton at Focal Adhesions. (2006)
  • Author(s): H. Takahashi, K. Ueda, and N. Kioka
  • Organizer: 46th Annual Meeting of American Sciety of Cell Biology
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anchorage-dependent regulation of ERK2 activation: involvement of phosphatases and vinexin b (2006)
  • Author(s): N. Kioka
  • Organizer: Gordon Research Conferences "Signaling by Adhesion Receptor"
  • Place of Presentation: South Hadley, MA, US
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Vinexin a Promotes the Association of Vinculin with Cytoskeleton at Focal Adhesions (2006)
  • Author(s): H., Takahashi, K., Ueda, N., Kioka
  • Organizer: 46th ASCB Annual Meeting I
  • Place of Presentation: San Diego, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Anchorage-dependent regulation of ERK2 activation : involvement of phosphatases and vinexin b (2006)
  • Author(s): N., Kioka
  • Organizer: Gordon Research Conferences "Signaling by Adhesion Receptor"
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of Cell Migration and Anchorage-dependent Cell Signaling by Focal Adhesion Protein, vinexin (2005)
  • Author(s): N. Kioka
  • Organizer: The 44th Annual Meeting of Korean Society for Life Science
  • Place of Presentation: Jinju, Korea
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of Cell Migration and Anchorage-dependent Cell Signaling by Focal Adhesion Protein, vinexin (2005)
  • Author(s): N., Kioka
  • Organizer: The 44th Annual Meeting of Korean Society for Life Science
  • Place of Presentation: Korea
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ERK2 activated by EGF and cell adhesion interacts with and phosphor ylates vinexin (2004)
  • Author(s): N. Kioka
  • Organizer: Gordon Research Conferences "Signaling by Adhesion Receptor"
  • Place of Presentation: Bristol, RI, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ERK2 activated by EGF and cell adhesion interacts with and phosphorylates vinexin (2004)
  • Author(s): N., Kioka
  • Organizer: Gordon Research Conferences "Signaling by Adhesion Receptor"
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.biochemistry.kais.kyoto-u.ac.jp/