Morphological and molecular biological analyses for the mechanism of vascular development in the embryogenesis
| Project/Area Number |
16390049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Iwate Medical University |
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Principal Investigator |
HITOMI Jiro Iwate Medical University, School of Medicine, Professor (00218728)
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| Co-Investigator(Kenkyū-buntansha) |
ISOGAI Sumio Iwate Medical University, School of Medicine, Lecturer (60212966)
KAMO Masaharu Iwate Medical University, School of Dentistry, Associate Professor (40214564)
HABANO Wataru Iwate Medical University, School of Medicine, Assistant Professor (50332979)
SHOUJI Wataru Tohoku University Institute of Development, Aging and Cancer, Assistant Professor (40250831)
小岩 弘之 東北化学薬品(株), 生命システム情報研究所, 所長
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2004: ¥8,500,000 (Direct Cost: ¥8,500,000)
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| Keywords | angiogenesis / vasculogenesis / lymphatic vessel / transcription factor / zebrafish / rat / organogenesis / kidney / 血管 / 血球分化 / 血管伸長ガイダンス因子 / ゼブラフィッシュ / 二光子顕微鏡 / イメージング / 脳血管 / 血管内皮細胞 / 遺伝子発現 |
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| Research Abstract |
The morphological and molecular biological analyses for the vascular development showed us the following novel phenomena precisely.
Renal and the related arteries vary in their level of origin and in their calibre, number and precise anatomical relationship to other structures. Studies of the origin and early development of these arteries have evoked sharp disputes. The ladder theory of Felix, which states that 'All the mesonephric arteries may persist ; from them are formed the phrenic, suprarenal, renal and internal spermatic arteries' has been generally quoted in the anatomical textbooks without rigorous verification for 100 years. In this study, we re-examined this theory by performing micro-injection of dye and resin into rat embryos. Our results revealed that most of the mesonephric arteries had degenerated before the metanephros started its ascent The definitive renal and the related arteries appeared as new branches from the gonadal artery and/or directly from the abdominal aort
… More
a to the para-aortic ridge. We also demonstrated that the route of venous drainage changed from the posterior cardinal vein to the inferior (caudal) vena cava.
The lymphatic system has become the subject of great interest in recent years because of its important role in normal and pathological processes. Progress in understanding the origins and early development of this system, however has been hampered by difficulties in observing lymphatic cells in vivo and in performing defined genetic and experimental manipulation of the lymphatic system in currently available model organisms. However we could show that the optically clear developing zebrafish provides a useful model for imaging and studying lymphatic development, with a lymphatic system that shares many of the morphological, molecular and functional characteristics of the lymphatic vessels found in other vertebrates. Our results showed lymphatic endothelial cells of the thoracic duct arise from primitive veins through a novel and unexpected pathway. Less
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Report
(4 results)
Research Products
(30 results)
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[Presentation] 馬蹄腎に分布する動脈2005
Author(s)
堀口・泉山真由子, 相澤幸夫, 磯貝純夫, 燕軍, 人見次郎
Organizer
第110回日本解剖学会総会・全国学術集会
Place of Presentation
富山
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Morphological features of the alimentary tract and its blood supply in the adult zebrafish2004
Author(s)
Ono,T., Isogai,S., Yan,J., Aizawa,Y., Weinstein B.M., Ajioka,Y., Hitomi.J.
Organizer
16th International Congress of the IFAA
Place of Presentation
Kyoto
Description
「研究成果報告書概要(和文)」より
Related Report
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