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Research of the role of growth hormone in adult

Research Project

Project/Area Number 16390270
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKobe University

Principal Investigator

CHIHARA Kazuo  Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00107955)

Co-Investigator(Kenkyū-buntansha) OKIMURA Yasuhiko  Kobe University, Graduate School of Medicine, Associate Professor, 医学部, 助教授 (30204100)
TAKAHASHI Yutaka  Kobe University, Graduate School of Medicine, Lecturer, 医学部附属病院, 講師 (70301281)
井口 元三  神戸大学, 大学院・医学系研究科, 助手 (60346260)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2005: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2004: ¥9,600,000 (Direct Cost: ¥9,600,000)
Keywordsgrowth hormone / adult growth hormone deficiency / metabolic syndrome / gene expression profile / cDNA microarray / 成人成長ホルモン欠損症 / モデルマウス / 成長ホルモン標的遺伝子
Research Abstract

It is well known that increased visceral fat, decreased lean body mass, decreased total body water, reduced quality of life, sense of vitality, reduced bone mineral density, abnormal lipid profile and increased risk of cardiovascular disease are commonly seen in adult growth hormone deficiency (AGHD). In this study, we have attempted to clarify the significance of GH in metabolic syndrome and ageing by approaching the analysis of pathophysiology in AGHD using an animal model. We found GH deficient rat, known as spontaneous dwarf rat (SDR) demonstrated that visceral obesity and fatty liver, suggesting a good animal model for AGHD. Next we have analyzed gene expression profiles in various tissues in SDR using cDNA microarray. In the heart, we found that GH regulates essential molecules which regulate structural, contractile, remodeling and regenerative functions. Also, in the liver, GH regulated many metabolic regulating enzymes which explained fatty liver change in AGHD (manuscript in preparation). We cloned a novel chemokine as a GH-induced gene in Hepatocyes and the chemokine enhanced insulin-induced glucose uptake in adiopocyte (submitted). We further are investigating the molecular mechanisms of AGHD using these animal model.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (73 results)

All 2006 2005 2004

All Journal Article (73 results)

  • [Journal Article] Gene expression profile in the heart of spontaneous dwarf rat : in vivo effects of growth hormone2006

    • Author(s)
      Yoshioka S et al.
    • Journal Title

      Biochem Biophys Res Commun. 341(1)

      Pages: 88-93

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] An individualized GH dose regimen for long-term GH treatment in Japanese patients with adult GH deficiency.2005

    • Author(s)
      Chihara K
    • Journal Title

      Eur J Endocrinol 153

      Pages: 57-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Low-dose parathyroid hormone and estrogen reverse alkaline phosphatase activity suppressed by dexamethasone in mouse osteoblastic cells.2005

    • Author(s)
      Iu MF
    • Journal Title

      J Bone Miner Metab 23

      Pages: 450-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Dexamethasone suppresses Smad3 pathway in osteoblastic cells.2005

    • Author(s)
      Iu MF
    • Journal Title

      J Endocrinol 185

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography : comparisons between female and male.2005

    • Author(s)
      Kaji H
    • Journal Title

      Endocr J 52

      Pages: 659-666

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The threshold of bone mineral density for vertebral fractures in female patients with primary hyperparathyroidism.2005

    • Author(s)
      Kaji H
    • Journal Title

      Eur J Endocrinol 152

      Pages: 373-378

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures.2005

    • Author(s)
      Kaji H
    • Journal Title

      Horm Metab Res 37

      Pages: 589-592

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Body composition and vertebral fracture risk in female patients treated with glucocorticoid.2005

    • Author(s)
      Kaji H
    • Journal Title

      Osteoporos Int. Dec 31

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transforming growth factor-beta enhances connective tissue growth factor expression in L6 rat skeletal myotubes.2005

    • Author(s)
      Maeda N
    • Journal Title

      Neuromuscul Disord 15

      Pages: 790-793

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.2005

    • Author(s)
      Murata M
    • Journal Title

      Int J Mol Med 15

      Pages: 649-653

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD.2005

    • Author(s)
      Naito J
    • Journal Title

      J Biol Chem 280

      Pages: 4785-4791

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Activation of the precuneus is related to reduced reaction time in serial reaction time tasks.2005

    • Author(s)
      Oishi K
    • Journal Title

      Neurosci Res 52

      Pages: 37-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The role of transcriptional coactivator TRAP22O in myelomonocytic differentiation.2005

    • Author(s)
      Urahama N
    • Journal Title

      Genes Cells 10

      Pages: 1127-1137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Successful treatment with defibrotide for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation.2005

    • Author(s)
      Yakushijin K
    • Journal Title

      Kobe J Med Sci 51

      Pages: 55-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Multiple vertebral fractures are associated with refractory reflux esophagitis in postmenopausal women.2005

    • Author(s)
      Yamaguchi T
    • Journal Title

      J Bone Miner Metab 23

      Pages: 36-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells.2005

    • Author(s)
      Yamauchi M
    • Journal Title

      Am J Physiol Endocrinol Metab 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] GH作用機構-GH受容体情報伝達とその制御 (総説)2005

    • Author(s)
      高橋 裕
    • Journal Title

      ホルモンと臨床 8

      Pages: 3-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] インスリン抵抗性 下垂体・甲状腺・副腎2005

    • Author(s)
      高橋 裕
    • Journal Title

      総合臨床 7

      Pages: 1633-1637

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] シグナル伝達と臨床応用-アプローチ2005

    • Author(s)
      高橋 裕
    • Journal Title

      最新医学 7

      Pages: 1515-1520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 【臨床で出遭う内分泌疾患】内分泌検査の選択と結果をどう読むか? 下垂体機能検査2005

    • Author(s)
      飯田啓二
    • Journal Title

      Medicina 42

      Pages: 1184-1187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 【内分泌疾患UPDATE】 視床下部-下垂体 成長ホルモン遺伝子異常による成長障害 成長ホルモン分泌不全症と作用異常症2005

    • Author(s)
      飯田啓二
    • Journal Title

      医学のあゆみ 213

      Pages: 337-341

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 【インスリン抵抗性 チアゾリジン誘導体の臨床応用を中心に】インスリン抵抗性関連疾患とその対策下垂体・甲状腺・副腎疾庸2005

    • Author(s)
      高橋裕
    • Journal Title

      綜合臨床 54

      Pages: 11633-1637

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 基本的転写共役因子TRAP220による骨髄系細胞の分化調節2005

    • Author(s)
      伊藤光宏
    • Journal Title

      日本癌学会64回総会記事

      Pages: 164-65

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 脳室上衣腫合併MEN1型の一例と副甲状腺におけるMeninの検討2005

    • Author(s)
      飛松崇子
    • Journal Title

      日本内分泌学会雑誌 81

      Pages: 101-103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Prader-Willi症候群2例の代謝異常についての検討2005

    • Author(s)
      福岡秀規
    • Journal Title

      日本内分泌学会雑誌 81

      Pages: 16-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells.2005

    • Author(s)
      Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K
    • Journal Title

      Am J Physiol Endocrinol Metab 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multiple vertebral fractures are associated with refractory reflux esophagitis in postmenopausal women.2005

    • Author(s)
      Yamaguchi T, Sugimoto T, Yamauchi M, Matsumori Y, Tsutsumi M, Chihara K
    • Journal Title

      J Bone Miner Metab 23

      Pages: 36-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Successful treatment with defibrotide for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation.2005

    • Author(s)
      Yakushijin K, Matsui T, Okamura A, Yamamoto K, Ito M, Chihara K
    • Journal Title

      Kobe J Med Sci 51

      Pages: 55-65

    • NAID

      110004091735

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.2005

    • Author(s)
      Urahama N, Ito M, Sada A, Yakushijin K, Yamamoto K, Okamura A, Minagawa K, Hato A, Chihara K, Roeder RG, Matsui T
    • Journal Title

      Genes Cells 10

      Pages: 1127-1137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Activation of the precuneus is related to reduced reaction time in serial reaction time tasks.2005

    • Author(s)
      Oishi K, Toma K, Bagarinao ET, Matsuo K, Nakai T, Chihara K, Fukuyama H
    • Journal Title

      Neurosci Res 52

      Pages: 37-45

    • NAID

      10016475964

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD.2005

    • Author(s)
      Naito J, Kaji H, Sowa H, Hendy GN, Sugimoto T, Chihara K
    • Journal Title

      J Biol Chem 280

      Pages: 4785-4791

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.2005

    • Author(s)
      Murata M, Miura Y, Hashiramoto A, Kitamura H, Kawasaki H, Shiozawa K, Yoshiya S, Baba H, Chihara K, Shiozawa S
    • Journal Title

      Int J Mol Med 15

      Pages: 649-653

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transforming growth factor-beta enhances connective tissue growth factor expression in L6 rat skeletal myotubes.2005

    • Author(s)
      Maeda N, Kanda F, Okuda S, Ishihara H, Chihara K
    • Journal Title

      Neuromuscul Disord 15

      Pages: 790-793

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Body composition and vertebral fracture risk in female patients treated with glucocorticoid.2005

    • Author(s)
      Kaji H, Tobimatsu T, Naito J, Iu MF, Yamauchi M, Sugimoto T, Chihara K
    • Journal Title

      Osteoporos Int. 2005

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Statins modulate the levels of osteoprotegerin/receptor activator of NEkappaB ligand mRNA in mouse bone-cell cultures.2005

    • Author(s)
      Kaji H, Kanatani M, Sugimoto T, Chihara K
    • Journal Title

      Horm Metab Res 37

      Pages: 589-592

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The threshold of bone mineral density for vertebral fractures in female patients with primary hyperparathyroidism.2005

    • Author(s)
      Kaji H, Yamauchi M, Chihara K, Sugimoto T
    • Journal Title

      Eur J Endocrinol 153

      Pages: 373-378

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography : comparisons between female and male.2005

    • Author(s)
      Kaji H, Kosaka R, Yamauchi M, Kuno K, Chihara K, Sugimoto T
    • Journal Title

      Endocr J 52

      Pages: 659-666

    • NAID

      10016916212

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dexamethasone suppresses Smad3 pathway in osteoblastic cells.2005

    • Author(s)
      Iu MF, Kaji H, Sowa H, Naito J, Sugimoto T, Chihara K
    • Journal Title

      J Endocrinol 185

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Low-dose parathyroid hormone and estrogen reverse alkaline phosphatase activity suppressed by dexamethasone in mouse osteoblastic cells.2005

    • Author(s)
      Iu MF, Kaji H, Naito J, Sowa H, Sugimoto T, Chihara K
    • Journal Title

      J Bone Miner Metab 23

      Pages: 450-455

    • NAID

      10017133652

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An individualized GH dose regimen for long-term GH treatment in Japanese patients with adult GH deficiency.2005

    • Author(s)
      Chihara K, Koledova E, Shimatsu A, Kato Y, Kohno H, Tanaka T, Teramoto A, Bates PC, Attanasio AF
    • Journal Title

      Eur J Endocrinol 153

      Pages: 57-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of age, grip strength and smoking, on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography : comparisons between female and male.2005

    • Author(s)
      Kaji H
    • Journal Title

      Endocr J 52

      Pages: 659-666

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The threshold of bone mineral density for vertebral fractures in female patients with primary hyperparathyroidism.2005

    • Author(s)
      Kaji H
    • Journal Title

      Eur J Endocrinol 153

      Pages: 373-378

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Body composition and vertebral fracture risk in female patients treated with glucocorticoid.2005

    • Author(s)
      Kaji H
    • Journal Title

      Osteoporos Int. Dec31

      Pages: 1-7

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transforming. growth factor-beta enhances connective tissue growth factor expression in L6 rat skeletal myotubes.2005

    • Author(s)
      Maeda N
    • Journal Title

      Neuromuscul Disord 15

      Pages: 790-793

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.2005

    • Author(s)
      Urahama N
    • Journal Title

      Genes Cells 10

      Pages: 1127-1137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] GH作用機構-GH受容体情報伝達とその制御(総説)2005

    • Author(s)
      高橋 裕
    • Journal Title

      ホルモンと臨床 8

      Pages: 3-8

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 【内分泌疾患UPDATE】視床下部-下垂体成長 ホルモン遺伝子異常による成長障害 成長ホルモン分泌不全症と作用異常症2005

    • Author(s)
      飯田啓二
    • Journal Title

      医学のあゆみ 213

      Pages: 337-341

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 【インスリン抵抗性 チアゾリジン誘導体の臨床応用を中心に】インスリン抵抗性関連疾患とその対策下垂体・甲状腺・副腎疾患2005

    • Author(s)
      高橋裕
    • Journal Title

      綜合臨床 54

      Pages: 1633-1637

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.2004

    • Author(s)
      Yoshioka S, Okimura Y, Takahashi Y, Iida K, Kaji H, Matsuo M, Chihara K
    • Journal Title

      Life Sci 74

      Pages: 2097-2109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determinants of vertebral fragility : the participation of cortical bone factors.2004

    • Author(s)
      Yamauchi M, Sugimoto T, Chihara K
    • Journal Title

      J Bone Miner Metab 22

      Pages: 79-85

    • NAID

      50000004924

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects.2004

    • Author(s)
      Takeno R, Okimura Y, Iguchi G, Kishimoto M, Kudo T, Takahashi K, Takahashi Y, Kaji H, Ohno M, Ikuta H, Kuroda Y, Obara T, Hosoda H, Kangawa K, Chihara K
    • Journal Title

      Eur J Endocrinol 151

      Pages: 447-450

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2.2004

    • Author(s)
      Sowa H, Kaji H, Hendy GN, Canaff L, Komori T, Sugimoto T, Chihara K
    • Journal Title

      J Biol Chem 279

      Pages: 40267-40275

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion.2004

    • Author(s)
      Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K
    • Journal Title

      Cancer Res 64

      Pages: 2222-2228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] HLA typing in focal myositis.2004

    • Author(s)
      Sekiguchi K, Kanda F, Oishi K, Hamaguchi H, Nakazawa K, Maeda N, Ishihara H, Chihara K
    • Journal Title

      J Neurol Sci 227

      Pages: 21-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Long-term improvement of puality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H).2004

    • Author(s)
      Rosilio M, Blum WF, Edwards DJ, Shavrikova EP, Valle D, Lamberts SW, Erfurth EM, Webb SM, Ross RJ, Chihara K, Henrich G, Herschbach P, Attanasio AF
    • Journal Title

      J Clin Endocrinol Metab 89

      Pages: 1684-1693

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Subacute bulbar palsy as the initial sign of follicular thyroid cancer.2004

    • Author(s)
      Okuda S, Kanda F, Kawamoto K, Chihara K
    • Journal Title

      Intern Med 43

      Pages: 997-999

    • NAID

      130000084173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of casein kinase lepsilon in cytokine-induced granulocytic differentiation.2004

    • Author(s)
      Okamura A, Iwata N, Nagata A, Tamekane A, Shimoyama M, Gomyo H, Yakushijin K, Urahama N, Hamaguchi M, Fukui C, Chihara K, Ito M, Matsui T
    • Journal Title

      Blood 103

      Pages: 2997-3004

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Marked and sustained increase in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism ; a six-year longitudinal study with or without parathyroidectomy in a Japanese population.2004

    • Author(s)
      Nomura R, Sugimoto T, Tsukamoto T, Yamauchi M, Sowa H, Chen Q, Yamaguchi T, Kobayashi A, Chihara K
    • Journal Title

      Clin Endocrinol (Oxf) 60

      Pages: 335-342

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Focal myositis in monozygotic twins.2004

    • Author(s)
      Naggar EA, Kanda F, Okuda S, Maeda N, Nakazawa K, Oishi K, Sekiguchi K, Ishihara H, Chihara K
    • Journal Title

      Intern Med 43

      Pages: 599-601

    • NAID

      130000084922

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction.2004

    • Author(s)
      Kanatani M, Sugimoto T, Sowa H, Kobayashi T, Kanzawa M, Chihara K
    • Journal Title

      J Cell Physiol 201

      Pages: 17-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct causes of death in Japanese patients with hypopituitarism as analyzed from a nation-wide autopsy database.2004

    • Author(s)
      Kaji H, Chihara K
    • Journal Title

      Eur J Endocrinol 150

      Pages: 149-152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred.2004

    • Author(s)
      Iida K, Okimura Y, Takahashi K, Inomata S, Iguchi G, Kaji H, Chihara K
    • Journal Title

      Int J Mol Med 13

      Pages: 401-404

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel splice site mutation of the thiazide-sensitive NaCl cotransporter gene in a Jananese patient with Gitelman syndrome.2004

    • Author(s)
      Iida K, Hanafusa M, Maekawa I, Kudo T, Takahashi K, Yoshioka S, Kishimoto M, Iguchi G, Tsukamoto T, Okimura Y, Kaji H, Chihara K
    • Journal Title

      Clin Nephrol 62

      Pages: 180-184

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Metabolic effects of 20-kilodalton human growth hormone (20K-hGH) for adults with growth hormone deficiency : results of an exploratory uncontrolled multicenter clinical trial of 20K-hGH.2004

    • Author(s)
      Hayakawa M, Shimazaki Y, Tsushima T, Kato Y, Takano K, Chihara K, Shimatsu A, Irie M
    • Journal Title

      J Clin Endocrinol Metab 89

      Pages: 1562-1571

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct effects of tumor necrosis factor alpha (TNF-alpha) on L6 myotubes.2004

    • Author(s)
      el-Naggar EA, Kanda F, Okuda S, Maeda N, Nishimoto K, Ishihara H, Chihara K
    • Journal Title

      Kobe J Med Sci 50

      Pages: 39-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Adult GH deficiency in Japanese patients : effects of GH treatment in a randomised, placebo-controlled trial.2004

    • Author(s)
      Chihara K, Koledova E, Shimatsu A, Kato Y, Kohno H, Tanaka T, Teramoto A, Bates PC, Attanasio AF
    • Journal Title

      Eur J Endocrinol 151

      Pages: 343-350

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Testosterone increases osteoprotegerin mRNA expression in mouse osteoblast_cells.2004

    • Author(s)
      Chen Q, Kaji H, Kanatani M, Sugimoto T, Chihara K
    • Journal Title

      Horm Metab Res 36

      Pages: 674-678

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A novel splice site mutation of the thiazide-sensitive NaCl cotransporter gene in a Japanese patient with Gitelman syndrome2004

    • Author(s)
      Iida, K et al.
    • Journal Title

      Clin Nephrol 62

      Pages: 180-184

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intravenous administration of ghrelin stimulates growth hormone secretion in vagotomized patients as well as normal subjects2004

    • Author(s)
      Takeno, R et al.
    • Journal Title

      Eur J Endocrinol 151

      Pages: 447-450

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Adult GH deficiency in Japanese patients : effects of GH treatment in a randomised, placebo-controlled trial2004

    • Author(s)
      Chihara, K et al.
    • Journal Title

      Eur J Endocrinol 151

      Pages: 343-350

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC2004

    • Author(s)
      Yoshioka, S.et al.
    • Journal Title

      Life Sci 74

      Pages: 2097-2109

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred2004

    • Author(s)
      Iida, K.et al.
    • Journal Title

      Int J Mol Med 13

      Pages: 401-404

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx22004

    • Author(s)
      Sowa, H.et al.
    • Journal Title

      J Biol Chem 279

      Pages: 40267-40275

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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