Development of CT radiotherapy machine equipped with micro multileaf collimator

• Project/Area Number: 16390342
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: KUNIEDA Etsuo Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (70170008)
• Co-Investigator(Kenkyū-buntansha): KAWAGUCHI Osamu Keio University, School of Medicine, Assistant Instructor, 医学部, 助手 (90276428) ; SAITOU Hidetoshi Tokyo Metropolitan University, epartment of Health & Welfare, Professor, 健康福祉学部, 教授 (50196002) ; OGAWA Koichi Hosei University, Department of Technology, Professor, 工学部, 教授 (00158817)
• Project Period (FY): 2004 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥7,900,000 (Direct Cost: ¥7,900,000); Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2004: ¥6,900,000 (Direct Cost: ¥6,900,000)
• Keywords: Monte Carlo simulation / keV / Stereotacitc / X-CT / radiotherapy / Micro Multileaf / 低エネルギーX線

Research Abstract

An experimental kilovoltage CT radiotherapy machine with dedicated micro multileaf collimators was developed, which will be used for imaging as well as for kilo-voltage Tomotherapy. Preliminary trails of this system were investigated by observing the dose distributions in water and thorax phantoms., for the kilo-voltage energies and a comparison was done with the MeV energy from Co-60 source. Animal studies were carried out with rabbits. Phantom experiments were performed to acquire the energy spectra of 100,120 and 135 keV from CT measurements and compared those results with Monte Carlo simulations. The Percentage of Depth Dose (PDD) in the water phantom calculated from the experimental and simulated spectra show good agreement with each other. The PDD of 135 keV spectra at 5,10 and 15 cm depths were 30%,12% and 5%, respectively. Dose distributions in water phantom at a depth of 12 cm for 200 keV energy was almost 3 times lower than that dose of Co-60 photons and dose distributions in the lung region of a thorax phantom demonstrated the possibility of Tomotherapy with our kilo-voltage radiotherapy machine. A detail performance of this system as kilo-voltage conformal Tomotherapy has been investigated with animal studies, and the long term results are obtained in the near feature

Research Products

• [Journal Article] 肺腫瘍定位照射におけるKilo-voltageとMega-voltage X線のMonte Carlo simulationによる比較 (2005)
  • Author(s): 角尾卓紀, Deloar HM, 国枝悦夫, 他
  • Journal Title: 高精度放射線外部照射研究会抄録,2005 12・1 Pages: 81-81
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of an Interface for DOSXYZnrc Monte Carlo does on Xio RTP System (2005)
  • Author(s): Kunieda E, Deloar H, Takagi S, et al.
  • Journal Title: ICMP2005/BMT2005 Proceeding Pages: 301-302
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Experimental model of radiation sequelae induced with single steretactic irradiation to normal rabbit lung. Computed tomogtaghical analysis (2005)
  • Author(s): Kuwase T, Kunieda E
  • Journal Title: Proceedings of ECCO 13
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 異なる施設間での肺小腫瘤GTVの解析 (2005)
  • Author(s): 関智史, Hossain, M Deloar, 国枝悦夫 他
  • Journal Title: 日本放射線腫瘍学会誌 17(1) Pages: 25-30
  • NAID: 10027060528
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Small lung tumors : long-scan-time CT for planning of hypofractionated stereotactic radiation therapy-initial findings (2005)
  • Author(s): Takeda, A., Kunieda, E., Shigematsu, N., et al.
  • Journal Title: Radiology 237(1) Pages: 295-300
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Successful pregnancy and noramal delivery after whole craniospinal irradiation in two patients (2005)
  • Author(s): Shigematsu, N., Shimoto, H., Ito, N., Kunieda, E., Takeda, A., et al.
  • Journal Title: Anticancer Res 25(5) Pages: 3481-3487
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differences in pulmonary function before vs. 1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumors (2005)
  • Author(s): Ohashi, T., Takeda, A., Shigematsu, N., Kunieda, E.et al.
  • Journal Title: Int J Radiat Oncol Biol Phys 62(4) Pages: 1003-1008
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 高齢者の早期前立腺癌に対する,集光照射法を用いた非侵襲的な4次元放射線治療システムの開発 (2005)
  • Author(s): 川瀬貴嗣, 国枝悦夫, Deloar Hossain M
  • Journal Title: 大和証券ヘルス財団研究業績集 28 Pages: 87-92
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differences in pulmonary function before vs.1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumors. (2005)
  • Author(s): Ohashi, T., Takeda, A., Shigematsu, N., Kunieda, E., Ishizaka, A., Fukada, J., Deloar, H.M., Kawaguchi O., Takeda, T., Takemasa, K., Isobe, K., Kudo, A.
  • Journal Title: Int J Radiat Oncol Biol Phys 62(4) Pages: 1003-1008
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dose Calculation system for remotely supporting radiotherapy. (2005)
  • Author(s): Saito, K., Kunieda, E., Narita, Y., Kimura.H., Hirai, M., Deloar, H.M., Kaneko, K., Ozaki, M., Fujisaki, T., Myojoyama, A., Saitoh, H.
  • Journal Title: Radial Prot Dosimetry 116(1-4 Pt2) Pages: 190-195
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Successful pregnancy and normal delivery after whole craniospinal irradiation in two patients. (2005)
  • Author(s): Shigematsu, N., Shinmoto, H., Ito.N., Kunieda, E., Takeda, A., Ohashi, T., Kawaguchi, O., Kawata, T., Ito, H., Kuribayashi, S., Kubo, A.
  • Journal Title: Anticancer Res 25(5) Pages: 3481-3487
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small lung tumors : long-scan-time CT for planning of hypofractionated stereotactic radiation therapy-initial findings. (2005)
  • Author(s): Takeda, A., Kunieda, E., Shigematsu, N., Hossain, D.M., Kawase, T., Ohashi, T., Fukada, J., Kawaguchi, O., Uematsu, M., Takeda, T., Takemasa, K., Takahashi, T., Kubo, A.
  • Journal Title: Radiology. 237(1) Pages: 295-300
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Investigations of Suitable Kilo-Voltage X-ray energy for 3DCRT system with Monte Carlo Simulations (2005)
  • Author(s): Deloar, H., Kunieda, E., Kawase, T., Saitoh, H., Ozaki, M., Fnjisaki, T., Myojoyama, A., Saito, K., Takagi, S., Sato, O., Kubo.A.
  • Journal Title: The 14th Int'l Conference of Medical Physics (ICMP 2005), Nuremberg, Germany
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Simultaneous SRS for multiple intracranial lesions with single isocenter usins micromultileaf collimator. (2005)
  • Author(s): Fokada, J.,.Kunieda, E., Kawaguchi, O., Seki, S., Shigematsu, N., Uematsu, M., Kubo, A.
  • Journal Title: The 17th ISRS Congress, Brussel, Belgium
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Visualization of DOSXYZnrc Monte Carlo simulation on RTP System (2005)
  • Author(s): Ishikawa, A., Deloar, H.M., Kunieda, E., Tsunoo, T., Kawase, T., Saitoh, H., Myojoyama, A., Tatsuya, F., Kubo, A.
  • Journal Title: The 18th Annual Meeting of the Japanese Society for Therapeutic Radiology and Oncology, Kawagoe, Saitama
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Converging raidotherapy with kilo-voltage x-ray energy on Hepatic tumors. (2005)
  • Author(s): Ishikawa, S., Deloar, H., Kunieda, E., Fujisaki, T, Tunoo, T., Saitoh, H., Fujibuchi, T.
  • Journal Title: The 4th Japan-korea Joint Meeting on Medical Physics and The 5th Asia-Oceania Congress of Medical Physics, Kyoto, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Experimental model of radiation sequelae induced with single stereotactic irradiation to normal rabbit lung, Computed tomographical analysis. (2005)
  • Author(s): Kawase, T., Kunieda, E.
  • Journal Title: The ECCO 13, Paris
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 肺腫瘍定位照射におけるKilo-voltageとMega-voltage X線のMonte Carlo simulationによる比較 (2005)
  • Author(s): 角尾卓紀, Deloar HM, 国枝悦夫, 他
  • Journal Title: 高精度放射線外部照射研究会抄録2005 12.1 Pages: 81-81
• [Journal Article] Development of an Interface for DOSXYZnrc Monte Carlo dose on XiO RTP System (2005)
  • Author(s): Kunieda E, Deloar H, Takagi S, et al.
  • Journal Title: In : ICMP2005/BMT2005 Proceeding Pages: 301-302
• [Journal Article] Experimental model of radiation sequelae induced with single stereotactic irradiation to normal rabbit lung. Computed tomographical analysis (2005)
  • Author(s): Kawase T., Kunieda E
  • Journal Title: Proceedings of ECCO 13
• [Journal Article] Measurement of beam-axis displacement from the isocenter during three-dimensional conformal radiosurgery with a micro-multileaf collimator (2004)
  • Author(s): E.Kunieda, O.Kawaguchi, H, A.Kubo
  • Journal Title: Radiotherapy and Oncology 70(1) Pages: 45-48
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Thmors : Serial Changes on Computed Tomography (2004)
  • Author(s): T.Takeda, A.Takeda, E.Kunieda 他7名
  • Journal Title: American Journal of -Rentogenology 182(5) Pages: 1123-1128
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] DdTe半導体検出器を搭載した小型ガンマカメラによるセンチネルリンパ節イメージング (2004)
  • Author(s): 藤井博史, 池田正, 神野浩光, 北川雄光, 中原理紀, 国枝悦夫, 中村佳代子, 北島正樹, 久保敦司
  • Journal Title: 日本医学放射線学会雑誌 64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 小型ガンマカメラの画質改善に関する検討 (2004)
  • Author(s): 藤井博史, 田中智香子, 尾川浩一, 中村佳代子, 中原理紀, 国枝悦夫, 北川雄光, 池田正, 北島正樹, 久保敦司
  • Journal Title: 核医学 41 Pages: 344-344
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ウサギ肺に対する定位照射による有害事象の実験的検討 (2004)
  • Author(s): 川瀬貴嗣, 国枝悦夫, ホサイン・デコア, 笠松智孝, 川口修, 武田篤也, 沓木章二, 中原理紀, 藤井博史, 久保敦司
  • Journal Title: 日本医学放射線学会雑誌 64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] AVM radiosurgery 治療計画における動脈造影dynamic CTの意義 (2004)
  • Author(s): 川口修, 国枝悦夫, 久保敦司
  • Journal Title: 定位放射線治療 Pages: 71-79
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 早期食道癌に対する放射線治療成績 (2004)
  • Author(s): 大橋俊夫, 茂松直之, 沓木章二, 川口修, 川瀬貴嗣, 緒方雄史, 国枝悦夫, 久保敦司
  • Journal Title: 日本医学放射線学会雑誌 64
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] I期非小細胞肺がんに対する治療戦略 小腫瘤に照射する際の諸問題 (2004)
  • Author(s): 国枝悦夫, Hossain Deloar, 関智史, 斉藤秀敏, 武田篤也, 久保敦司
  • Journal Title: 日本放射線腫瘍学会誌 16 Pages: 77-77
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Thallium SPECTを用いた腫瘍診断 CTとのimage fusionの有用性について (2004)
  • Author(s): 中原理紀, 藤井博史, 茂松直之, 国枝悦夫, 橋本順, 久保敦司
  • Journal Title: 核医学 41 Pages: 353-353
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Evaluation of novel modified tangential irradiation technique for breast cancer patients using does-volume histograms (2004)
  • Author(s): Takeda, A, Shigematsu, N, Ikeda, T, Kawaguchi, O, Kutsuki, S, Ishibashi, R, Kunieda E, et al.
  • Journal Title: Int J Radiat Oncol Biol Phys. 58(4) Pages: 1280-1288
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery (2004)
  • Author(s): Kawaguchi, O., Kunieda, E., Fujii, H., Shigematsu, N., Kutsuki, Itou, H., Kubo, A.
  • Journal Title: Radiat Med 22(3) Pages: 198-200
  • NAID: 10013428430
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of density changes in the chest on lung stereotactic radiotherapy (2004)
  • Author(s): Fujisaki, T., Kikuchi, K., Saitoh, H., Tohyama, N., Myojoyama, A., Osawa, A., Kuramoto, A., Abe, S., Inada, T., Kawase, T., Kunieda, E.
  • Journal Title: Radiat Med 22(4) Pages: 233-238
  • NAID: 10013780004
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Optimization of the Width of the Photopeak Energy Window in the TDCS Technique for Scatter Correction in Quantitative SPECT (2004)
  • Author(s): Deloar, H.M., Hiroshi, Watanabe, Kyeong Min, Kim, Toshiyuki, Aoi, Etsuo, Kunieda, Hirofumi, Fujii, Hidehiro, Iida
  • Journal Title: IEEE TRANSACTIONS ON NUCLEAR SCIENCE 51(3) Pages: 625-630
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Optimization of the Width of the Photopeak Energy Window in the TDCS Technique for Scatter Correction in Quantitative SPECT (2004)
  • Author(s): Deloar, H.M., Hiroshi, W., Kyeong Min, K., Toshiyuki, A., Etsuo, K., Hirofumi, F., Hidehiro I.
  • Journal Title: IEEE TRANSACTIONS ON NUCLEAR SCIENCE 51(3) Pages: 625-630
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of density changes in the chest on lung stereotactic radiotherapy. (2004)
  • Author(s): Fujisaki T., Kikuchi K., Saitoh H., Tohyama, N., Myojoyama, A., Osawa, A., Kuramoto, A., Abe, S., Inada, T., Kawase, T., Kunieda, E.
  • Journal Title: Radiat Med 22(4) Pages: 233-238
  • NAID: 10013780004
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Measurement of beam-axis displacement from the isocenter during three-dimensional conformal radiosurgery with a micro-multileaf collimator (2004)
  • Author(s): Kunieda, E., Kawaguchi, O., Saitoh, H., Fujisaki, T., Takeda, A., Kawase, T., Deloar, H.M., Shigematsu, N., Kubo, A.
  • Journal Title: Radiotherapy and Oncology 70(1) Pages: 45-48
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of realistic high-resolution whole-body voxel models of Japanese adult males and females of average height and weight, and application of models to radio-frequency electromagnetic-field dosimetry. (2004)
  • Author(s): Nagaoka, T., Watanabe, S., Sakurai, K., Kunieda, E., Watanabe, S., Taki, M., Yamanaka, Y.
  • Journal Title: Phys Med Biol 49(1) Pages: 1-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation of novel modified tangential irradiation technique for breast cancer patients using dose-volume histograms. (2004)
  • Author(s): Takeda, A., Shigematsu, N., Ikeda, T., Kawaguchi, O., Kutsuki, S., Ishibashi, R., Kunieda, E., Takeda, T., Takemasa, K., Ito, H., Uno, T., Jinno, H., Kubo, A.
  • Journal Title: Int J Radiat Oncol Biol Phys 58(4) Pages: 1280-1288
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors : Serial Changes on Computed Tomography. (2004)
  • Author(s): Takeda, T., Takeda, A., Kunieda, E., Ishizaka, A., Takemasa, K., Shimada, K., Yamamoto, S., Shigematsu, N., Kawaguchi, O., Fukada, J.-i., Ohashi, T., Kuribayashi, S., Kubo, A.
  • Journal Title: American Journal of Rentogenology 182(5) Pages: 1123-1128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Monte Carlo Simulations for Stereotactic Radiotherapy System with Various Kilo Voltage X-ray Energy (2004)
  • Author(s): Deloar, H., Kunieda, E., Kawase, T., Saitoh, H., Ozaki, M., Fujisaki, T., Myojoyama, A., Saito, K., Takagi, S., Sato, O., Kubo, A.
  • Journal Title: The 3rd International EGS Workshop, KEK, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of Stereotactic Radiotherapy System with Medium Energy X-ray Initial Trails with Water Phantom and Human Lung. (2004)
  • Author(s): Deloar, H., Kunieda, E., Kawase, T., Saitoh, H., Ozaki, M., Saito, K., Kubo, A.
  • Journal Title: The 10th Meeting of Japan 3D Conformal External Beam Radiotherapy, Tokyo Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tomotherapy with Kilo-Voltage X-ray Energy : Preliminary Trails with Monte Carlo Simulation. (2004)
  • Author(s): Deloar, H., Kunieda, E., Kawase, T., Saitoh, H., Toyama, N., Ozaki, M., Kimura, H., Fujisaki, T., Kubo, A.
  • Journal Title: The XIVth International Conference on the Use of Computers in Radiation Therapy(ICCR), Seou
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiotherapy with Kilo-Voltage X-ray Energy : Preliminary Trails with Monte Carlo Simulation. (2004)
  • Author(s): Deloar, H., Kunieda, E., Kawase, T., Saitoh, H., Toyama, N., Ozaki, M., Kimura, H., Fujisaki, T., Kubo, A.
  • Journal Title: The 87th Scientific Meeting of JSMP, Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stereotactic Radiotherapy System with Kilo Voltage X-ray Energy : Trails with Monte Carlo Simulation. (2004)
  • Author(s): Kawase, T., Deloar, H.M., Kunieda, E., Saitoh, H., Ozaki M., Kimura, H., Saito, K., Kubo, A.
  • Journal Title: The 22th International Conference of EuroPACS-MIR, Trieste, Italy
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Measurement of beam-axis displacement from the isocenter during three-dimensional conformal radiosurgery with a micro-multileaf collimator (2004)
  • Author(s): E.Kunieda, O.Kawaguchi, H., A.Kubo
  • Journal Title: Radiotherapy and Oncology 70(1) Pages: 45-48
• [Journal Article] Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors : Serial Changes on Computed Tomography (2004)
  • Author(s): T.Takeda, A.Takeda, E.Kunieda 他7名
  • Journal Title: American Journal of Rentogenology 182(5) Pages: 1123-1128
• [Journal Article] Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery
  • Author(s): Kawaguchi, O., Kunieda, E., Fujii, H., Shigematsu, N., Kutsuki, S., Itou, H., Kubo, A.
  • Journal Title: Radiat Med 22(3) Pages: 198-200
  • NAID: 10013428430
  • Description: 「研究成果報告書概要(欧文)」より