Logistic strategy for molecule-targeting therapy in brain tumors
| Project/Area Number |
16390416
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MINEURA Katsuyoshi Kyoto Prefectural University of Medicine, Department of Neurosurgery, Professor, 医学研究科, 教授 (70134103)
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| Co-Investigator(Kenkyū-buntansha) |
SASAJIMA Hiroyasu Kyoto Prefectural University of Medicine, Department of Neurosurgery, Associate Professor, 医学研究科, 助教授 (80196188)
OHWADA Kei Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (80332948)
KIMURA Satoshi Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (00301424)
KAWABE Takuya Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (10360033)
KURIOKA Hiroki Kyoto Prefectural University of Medicine, Department of Neurosurgery, Instructor, 医学研究科, 助手 (30405295)
今堀 良夫 京都府立医科大学, 医学研究科, 助教授 (80191899)
梅澤 邦彦 京都府立医科大学, 医学研究科, 助手
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2005: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2004: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Keywords | brain tumors / molecule-targeting therapy / logistics / malignancy / localization / PET / F-18-fluorodeoxyglucose / F-18-B-10-fluoroboronophenylalanine / C-11-methionine |
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| Research Abstract |
Determination of therapeutic management of brain tumors is based on both host factors of individual patients and tumor factors. Current development in functional neuroimaging such as PET characterizes in vivo tumor factors including physiological and biochemical process of brain tumors.
To test in vivo transport system and tumor proliferation of meningiomas, kinetic analysis using ^<18>F-fluorodeoxyglucose (FDG) or ^<18>F-fluoroboronophenylalanine-was obtained and compared with immunoreactivity to vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1). K1 was higher in meningiomas than in gliomas, and was higher in atypical than in benign meningiomas. k3 was correlated with a proliferating index, MIB-1 LI, in meningiomas. Immunohistochemically, meningiomas were less reactive to VEGF or Glut-1 than gliomas, but atypical meningiomas stained more intensely than benign meningiomas. High values for K1 and k3 indicate the aggressive proliferation of meningiomas, and in a
… More
typical meningiomas, the synergistic interaction of the high permeability and the large surface area yielded conditions conducive to glucose metabolism and tumor proliferation.
The uptake and distribution of FDG is important landmark for malignancy and tumor extent. The tumor portion including a peak FDG uptake portion is a target for accurate diagnosis of malignancy. High-grade gliomas show heterogeneous uptake patterns, reflecting a topographic variation of cellular composition consisting of aggregated tumor cells, necrosis, and peritumoral edema. Among mostly benign tumors such as meningioma and central neurocytoma, atypical subsets have a relatively high uptake of FDG. The maximum reduction of tumor mass may be applied, when atypical.
The present study indicates that logistic support factors enhance tumor growth including tumor angiogenesis. Clinical use of functional image less invasively provides multidisciplinary biologic characteristics and leads to more appropriate treatment based on the tumor factors, and may result in prolonging high levels of performance status in brain tumors. Less
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] 代謝2006
Author(s)
峯浦一喜
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Journal Title
グリオーマ-病態と治療-.(田渕和雄(編))(シュプリンガーフェアラーク東京)
Pages: 93-102
Description
「研究成果報告書概要(和文)」より
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