| Project/Area Number |
16500186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyoto University |
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Principal Investigator |
AMONO Akira Kyoto University, Informatics, Associate Professor, 情報学研究科, 助教授 (60252491)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Tetsuya Informatics, Professor, 情報学研究科, 教授 (00209561)
MIZUTA Shinobu Informatics, Assistant Professor, 情報学研究科, 助手 (40314265)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Biomedical Simulation / Heart Model / Myocardial Cell Model / Finite Element Method / Coupling Simulation Algorithm |
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| Research Abstract |
In this research, we developed a left ventricle model which incorporates accurate cell model based on the recent advances in the cell physiology research area and other biomechanical aspects which includes cell orientation, material properties of the myocardial tissue and circulation model. First, we developed an authoring tool of the left ventricle model which can modify many parameters included in the model. Next, we developed a coupling simulation system which can use arbitrary circulation model and the left ventricle model. We also developed a description language which can describe a left ventricle model or myocardial cell model and also an experimental protocol. These tools offer formal representation of biological simulation models and by combining ontology information, many researchers from engineering area or information science area can safely handle these models. Finally, we used our model to simulate the left ventricle motion and evaluated the end systolic wall stress. There are hypothesis that the wall stress becomes homogeneous in the normal left ventricle. However, from our simulation results, we found that the wall stress in the apex area becomes large compared to the other area. This implies that the wall motion at apex is different from the other area, and this finding may related to the empirical knowledge of the heart surgeon that the preserving apex area in Batista operation is important for the prognosis.
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