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Characterization of Biological Tissues by Polarization Analysis of diffused light

Research Project

Project/Area Number 16500303
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionSophia University

Principal Investigator

FUJII Mamiko  Sophia University, Faculty of Science & Technology, Professor (20173396)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Kiyoshi  Sophia University, Faculty of Science & Technology, Professor (00053653)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords2D polarization measurement of back scattered ligh / scattering pattern / back scattering / Monte Carlo method / intra cellular structure / tissue structure / モンテカルロシミュレーション
Research Abstract

The scattering properties of a tissue depend on the cell size, cell constituents and cell structure ; therefore, the measurement of scattering light can be useful for tissue characterization, metabolism monitoring and so on. In particular, backscattering is very sensitive to both the size of the subcellular structure and the polarization state. The conventional method employed to study the scattering from biological material involves goniophotometric measurement ; however, the sample for this method should be very thin. Because biological tissues have very strong scattering properties and incident polarized beam becomes diffusive light while passing through very short path.
This project aims to propose new method to obtain the 2D angular pattern of polarized backscattering light from small volume of turbid media such as living tissue without pretreatment. The system derives a single scattering component that has a specific angular distribution pattern depending on the constituents and s … More tructures of the scattering substances. We attempt to detect the angular distribution of the backscattered light by using a 2D imaging sensor. We developed a Monte Carlo simulation to estimate the photon propagation behavior of our experimental system. This simulation employed Mie scattering phase function and the results were normalized with incident beam power. The simulation results showed that the characteristic patterns, which contain information on the scattering particles and medium, are due to the scattering phenomenon that occurs only in a very small volume around the incident point. Moreover, the reduced scattering coefficient μs' served as a suitable index for estimating the influence of diffusive multiple scattering on the 2D pattern. The small pinhole system enables the suppression of the diffusive multiple scattering; therefore, the angular distribution of the informative single scattering component can be observed as a 2D image by using our system. We developed a basic experimental system that could obtain the 2D angular pattern of backscattering, and preliminary experiments using suspensions of polystyrene sphere in water were performed. We verified that the proposed system could obtain the 2D angular pattern of backscattered polarized light from even high scattering materials, with a μs' value of 1 mm^<-1>, which was equivalent to that obtained from biological materials. However, difference of intensity due to polarization direction was not clear compare to the predictions by the simulation. The reason of this discrepancy remains unsolved yet. In order to apply our method for tissue characterization, the experimental system should be improved further and new approaches to relate the 2D patterns of angular distribution to the tissue structure and constituents are required. Less

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (14 results)

All 2006 2005 2004

All Journal Article (14 results)

  • [Journal Article] 生体組織の2次元後方散乱偏光計測法の検討2006

    • Author(s)
      藤井 麻美子、中山 淑
    • Journal Title

      日本生体医工学会誌生体医工学 第44特別号

      Pages: 687-687

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 2D polarization measurement of backscattering from biological tissue2006

    • Author(s)
      Mamiko Fujii, Kiyoshi Nakayama
    • Journal Title

      Transaction of the Japanese Society for Medical and Biological Engineering Vol.44, Suppl.1

      Pages: 687-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 2次元後方散乱偏光計測の実験とシミュレーションによる検討2005

    • Author(s)
      藤井 麻美子、中山 淑
    • Journal Title

      日本生体医工学会誌生体医工学 第43巻特別号

      Pages: 328-328

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polarization measurement of backscattering from turbid media for tissue characterization2005

    • Author(s)
      M. Fujii, K. Nakayama
    • Journal Title

      IFMBE Proceedings EMBEC'05"3rd European Medical&Biological Engineering Conference, IFMBE European Conference on Biomedical Engineering" Vol.11

      Pages: 18421-18425

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 2-D polarization measurement of backscattering from turbid media : simulation and experiment2005

    • Author(s)
      Mamiko Fujii, Kiyoshi Nakayama
    • Journal Title

      Transaction of the Japanese Society for Medical and Biologicm Engineering Vol.43, Suppl.1

      Pages: 328-328

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polarization measurement of backscattering from turbid media for tissue characterization2005

    • Author(s)
      Mamiko Fujii, Kiyoshi Nakayama
    • Journal Title

      Proceedings of 3th European Medical & Biological Engineering Conference

      Pages: 18421-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 2次元後方散乱偏光計測の実験とシミュレーションによる検討2005

    • Author(s)
      藤井 麻美子, 中山淑
    • Journal Title

      日本エム・イー学会誌 生体医工学 第43巻特別号

      Pages: 328-328

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polarization measurement of backscattering from turbid media for tissue characterization2005

    • Author(s)
      M.Fujii, K.Nakayama
    • Journal Title

      IFMBE Proceedings EMBEC'05 "3rd European Medical & Biological Engineering Conference, IFMBE European Conference on Biomedical Engineering" Vol.11(CD-ROM)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 後方散乱偏光分析による生体組織同定の基礎的検討2004

    • Author(s)
      藤井 麻美子, 田中 秀和, 鈴木 彰文, 中山 淑
    • Journal Title

      日本エム・イー学会誌生体医工学 第42巻特別号

      Pages: 484-484

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polarization measurement of backscattering from turbid media:simulation and experiment2004

    • Author(s)
      Mamiko Fujii, Kiyoahi Nakayama
    • Journal Title

      Proceedings of The Second Asian and Pacific Rim Symposiumon Biophotonics IEEE Catalog No.04EX927

      Pages: 26-27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fundamental study of tissue characterization by polarization analysis of back scattering2004

    • Author(s)
      Mamiko Fujii, Hidekazu Tanaka, Akifumi Suzuki, Kiyoshi Nakayama
    • Journal Title

      Transaction of the Japanese Society for Medical and Biological Engineering Vol.42, Suppl.1

      Pages: 484-484

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Polarization measurement of backscattering from turbid media : simulation and experiment2004

    • Author(s)
      Mamiko Fujii, Kiyoshi Nakayama
    • Journal Title

      Proceedings of The Second Asian and Pacific Rim Symposium on Biophotonics, IEEE Catalog No.04E027

      Pages: 26-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 後方散乱偏光分析による生体組織同定の基礎的検討2004

    • Author(s)
      藤井麻美子, 田中秀和, 鈴木彰文, 中山淑
    • Journal Title

      日本エム・イー学会誌 生体医工学 第42巻特別号

      Pages: 484-484

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Polarization measurement of backscattering from turbid media : simulation and experiment2004

    • Author(s)
      M.Fujii, K.Nakayama
    • Journal Title

      The Second Asian and Pacific Rim Symposium on Biophotonics Proceedings IEEE Catalog No.04EX927

      Pages: 26-27

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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