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Control mechanism of pulmonary ventilation in response to exercise in humans

Research Project

Project/Area Number 16500383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical education
Research InstitutionPrefectural University of Hiroshima (2005-2006)
Hiroshima Prefectural Women's University (2004)

Principal Investigator

FUKUBA Yoshiyuki  Prefectural University of Hiroshima, Department of Health Science, Professor, 人間文化学部, 教授 (00165309)

Co-Investigator(Kenkyū-buntansha) MIURA Akira  Prefectural University of Hiroshima, Department of Health Sciences, Prafessor, 人間文化学部, 教授 (30190581)
NISHIYASU Takeshi  University of Tsukuba, Institute of Health and Sports Science, Associate Professor, 体育科学系, 助教授 (90237751)
HAYASHI Naoyuki  Kyushu University, Institute of Health Science, Associate Professor, 健康科学センター, 助教授 (80273720)
ENDO Masako  Prefectural University of Hiroshima, Department of Health Sciences, Research Associate, 人間文化学部, 助手 (30336911)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsexercise / pulmonary ventilation / physiological control
Research Abstract

While there are numerous afferent drives to the respiratory center to control exercise ventilation, one of the important drive certainly comes from the exercising skeletal muscles. Stimulation of afferent nerves with endings in hindlimb skeletal muscles is known to have marked reflex effects on the respiratory system of anesthetized animals. The recent animal studies appropriated the neural monitoring system to hemodynamic effect (i.e., a "flow-linked" control) of ventilation. Therefore, to investigated to verify this hypothesis, i.e., whether the mechanosensitive, flow-dependent stimulation in muscle can be linked the ventilatory control in response to exercise in humans, we performed the following experiments, 1; to investigate the effect of occluding of femoral blood flow on the post-exercise ventilatory response of both the sub-and supra-anaerobic threshold (AT) leg cycling, 2; to investigate the effect of static/intermittent compressing stimulus to the lower limb using the anti-shock pant on post-exercise ventilatory response from leg cycling exercise, 3; to investigate the effect of postural change from supine to upright (it means blood retention to the lower limb) just after the cessation of cycling exercise on post-exercise ventilatory response, and 4; to investigate the causal linkage of ventilatory depression and blood flow to the lower limb during cycling exercise just after the 5-minintentional hyperventilation to induce vasoconstriction. As a result, two experiments supported the hypothesis whereas the remaining two did not. Accordingly, further study is clearly needed to deserve these issues.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (11 results)

All 2007 2006 2005

All Journal Article (11 results)

  • [Journal Article] Effects of femoral vascular occlusion on ventilatory responses during recovery from exercise in human.2007

    • Author(s)
      Fukuba, Y. et al.
    • Journal Title

      Respiratory Physiology and Neurobiology 155・1

      Pages: 29-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Central circulatory and peripheral 02 extraction changes as interactive facilitators of pulmonary 02 uptake during a repeated high-intensity exercise protocol in humans.2007

    • Author(s)
      Fukuba, Y. et al.
    • Journal Title

      European Journal of Applied Physiology 99・4

      Pages: 361-369

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effects of femoral vascular occlusion on ventilatory responses during recovery from exercise in human.2007

    • Author(s)
      Fukuba, Y. et al.
    • Journal Title

      Respiratory Physiology and Neurobiology 155(1)

      Pages: 29-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Central circulatory and peripheral 02 extraction changes as interactive facilitators of pulmonary 02 uptake during a repeated high-intensity exercise protocol in humans.2007

    • Author(s)
      Fukuba, Y. et al.
    • Journal Title

      European Journal of Applied Physiology 99(4)

      Pages: 361-369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Volitional hyperventilation during ramp exercise to exhaustion.2006

    • Author(s)
      Walsh, M.L., Fukuba, Y.et al.
    • Journal Title

      Applied Physiology, Nutrition and Metabolism 31・3

      Pages: 211-217

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vasoconstriction and blood flow responses in visceral arteries to mental task.2006

    • Author(s)
      Hayashi, N., Fukuba, Y.et al.
    • Journal Title

      Experimental Physiology 91・1

      Pages: 215-220

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Volitional hyperventilation during ramp exercise to exhaustion.2006

    • Author(s)
      Walsh, M.L., Fukuba, Y.et al.
    • Journal Title

      Applied Physiology, Nutrition and Metabolism 31(3)

      Pages: 211-217

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vasoconstriction and blood flow responses in visceral arteries to mental task.2006

    • Author(s)
      Hayashi, N., Fukuba, Y.et al.
    • Journal Title

      Experimental Physiology 91(1)

      Pages: 215-220

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Volitional hyperventilation during ramp exercise to exhaustion2006

    • Author(s)
      Walsh, M.L., Fukuba, Y.et al.
    • Journal Title

      Applied Physiology, Nutrition, and Metabolism 31(3)(受理・印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Kinetics of pulmonary VO2 and femoral artery blood flow and their relationship during repeated bouts of heavy exercise.2005

    • Author(s)
      Endo, M., Fukuba, Y.et al.
    • Journal Title

      European Journal of Applied Physiology 95・5

      Pages: 418-430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Kinetics of pulmonary V02 and femoral artery blood flow and their relationship during repeated bouts of heavy exercise.2005

    • Author(s)
      Endo, M., Fukuba, Y.et al.
    • Journal Title

      European Journal of Applied Physiology 95(5)

      Pages: 418-430

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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