| Project/Area Number |
16500441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TAN Nobusuke Yamaguchi University, Faculty of Education, Professor (00179920)
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| Co-Investigator(Kenkyū-buntansha) |
SONE Ryoko Yamaguchi University, Faculty of Education, Associate Professor (50271078)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | exercise training / hypertension / chronic stress / nitric oxide / GABA / brain / rats / 運動 |
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| Research Abstract |
We investigated the effect of voluntary wheel running training on increase in resting blood pressure induced by chronic stress in male borderline hypertensive rats (BHR). We also examined the possibility that central GABAergic system and/or nitric oxide system in paraventricular nucleus (PVN) of hypothalamus might be involved in anti-hypertensive effects of voluntary wheel running training. BHR were divided into three groups: stress (S) group which chronically received tail shocks for 9 weeks (200 times/day, 5 days/wk), stress plus exercise (S-Ex) group which chronically received tail shocks and freely accessed to running wheels from their home cages, and control (C) group which received neither intervention. Arterial pressure was measured for 24 hours by using radio telemetry system on a non-stress day of every week. Resting mean arterial pressure was significantly elevated during chronic stress period in S group, but not significantly elevated in both S-Ex and C group (S (n=6): 105±4 and 114±7 mmHg during light period at 0 and 9wk, S-Ex (n=6): 105±7 and 109±9 mmHg during light period at 0 and 9 wk, C (n=5): 98±3 and 103±4 mmHg during light period at 0 and 9 wk). There was no significant difference in the number of nitric oxide synthase-positive cells in PVN between S and S-Ex group. Blood pressure response to intracerebroventricular injection of bicuculline, GABA receptor antagonist, did not differ between S and S-Ex group. These results suggest that voluntary wheel running training attenuates the rise in resting blood pressure induced by chronic stress, but it is unclear that central GABAergic system and nitric oxide system in PVN may be involved in this protective effect of exercise training.
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