| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shioto University of Yamanashi, Department of Research, Interdisciplinary Graduate School of Medicine and Engineering, Research Associate, 大学院・医学工学総合研究部, 助手 (40334859)
WATANABE Hideomi Gunma University, School of Medicine, Professor, 医学部, 教授 (40231724)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Research Abstract |
We have reported several diverse functions and abnormality of cell cycle regulator molecules in cultured cells and in human tumors. In the research during this term, analysis in correlation with aberration of oncogens was performed in soft tissue sarcomas, carcinomas of gastrointestinal tract and the lung. We clarified the followings.
i) Overexpression of cyclin D1 or ccdk4, which cause apoptosis in cultured cells, also caused apoptosis in lung carcinoma in vivo and it correlates with prognosis (Int.J.Cancer, 2004, Pathol.Int, 2005).
ii) Epidermal growth factor receptor (EGFR) is overexpressed in 10 to 15% of the cases in carcinomas of gastrointestinal tract, and overexpression is predominantly caused by gene amplification (Mod.Pathol. 2004, J.Pathol. 2005, Int.J.Cancer 2006).
iii) Overexpression of EGFR was observed in 1% of bone and soft tissue sarcomas, and those cases were exclusively associated with gene abnormality, i.e., amplification and polysomy (Mod.Pathol. 2004).
iv) By reviewing all resected cases of lung carcinomas in University of Yamanashi Hospital in the past 10 years, we found and reported that bronchioloalveolar carcinoma, newly defined in WHO classification (3rd Edition, 1999) never recur nor metastasize (Ann Thorac Surg, 2004).
v) Invasion-related protein, autocrine motility factor (AMF) were found to be expressed in 72.5% of the benign and malignant soft tissue tumors. The tumor expressing high level of mRNA and secreting AMF at high amount were found to be the cases showing high metastatic probability.
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