Development of therapeutics using interleukin-4 (IL-4) mutein in atherosclerotic mouse model showing Th1-dominant immune response

• Project/Area Number: 16590328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of the Ryukyus (2006-2007); Kurume University (2004-2005)
• Principal Investigator: KATO Seiya University of the Ryukyus, Medicine, Professor (60268844)
• Co-Investigator(Kenkyū-buntansha): HOSHINO Tomoaki Kurume University, Medicine, Lecturer (00261066)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: atherosclerosis / inflammation / Th1 response / cytokine / interleukin-4 (IL-4) / mouse / cell culture / Thl反応

Research Abstract

Inflammatory process of atherosclerosis and its therapeutic implication have been studied. LPA (Lysophosphatidic acid) showed mitogenic activity in the cultured smooth muscle cells as well as induction of NADPH-dependent intracellular oxidative stress, rac-1 (small GTPase) activation, and MCP-1 expression, of which pathway was inhibited by antioxidant and statin. Such in vitro experiments suggested an inflammatory phenotype of vascular cells. Administration of soluble INF_<-γ> receptor in ApoE knockout mice resulted in the suppression of atherogenesis. Moreover, STAT6 knockout mice (B6 backbone) showed not only Th1 shift in the immunological response but the phenotypes of obesity and glucose tolerance, suggesting a close relationship between inflammatory, immunological process and atherosclerosis or metabolic risk factors. Wild type mouse IL-4 gene and its specific cell oriented mutein, Q116E, were sub-cloned into adenovirus-derive expression (shuttle) vector. Primary mouse vascular cells were tested for the changes in inflammatory phenotypes. Development of replication-deficient adenoviral vector was attempting for in vivo experiments. These results further highlighted the importance of inflammatory process of atherosclerosis and suggest the therapeutic implications. We gratefully appreciate for supporting our work and continue to make our best effort to dissolve the pathological problems in human cardiovascular diseases.

Research Products

• [Journal Article] Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. (2008)
  • Author(s): Fukushima S, Kato S, Maeda M, Shigemori M.
  • Journal Title: Int J Oncol 32 Pages: 467-473
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] IL-18 production and pulmonary function in chronic obstructive pulmonary disease. (2008)
  • Author(s): Imaoka H, Hoshino T, Takei S, Kinoshita T, Okamoto M, Kawayama T, Kato S, Iwasaki H, Watanabe K, Aizawa H.
  • Journal Title: Eur Respir J 31 Pages: 287-297
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. (2008)
  • Author(s): Fukushima S
  • Journal Title: Int J Oncol 32 Pages: 467-473
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IL-18 production and pulmonary function in chronic obstructive pulmonary disease. (2008)
  • Author(s): Imaoka H
  • Journal Title: Eur Respir J 31 Pages: 287-297
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. (2008)
  • Author(s): Fukushima S, Kato S, Maeda M, Shigemori M
  • Journal Title: Int J Oncol 32 Pages: 467-473
  • Peer Reviewed
• [Journal Article] Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model. (2007)
  • Author(s): Imaoka H, Hoshino T, Takei S, Sakazaki Y, Kinoshita T, Okamoto M, Kawayama T, Yodoi J, Kato S, Iwanaga T, Aizawa H.
  • Journal Title: Biochem Biophys Res Commun 360 Pages: 525-530
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Postnatal blocking of interferon-gamma function prevented atheros clerotic plaque formation in apolipoprotein E-knockout mice. (2007)
  • Author(s): Koga M, Kai H, Yasukawa H, Kato S, Yamamoto T, Kawai Y, Kusaba K, Seki Y, Kai M, Egashira K, Kataoka Y, Imaizumi T.
  • Journal Title: Hypertens Res 30 Pages: 259-267
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibition of progression and stabilization of plaques by postnatal interferon-gamma function blocking in ApoE-knockout mice. (2007)
  • Author(s): Koga M, Kai H, Yasukawa H, Yamamoto T, Kawai Y, Kato S, Kusaba K, Kai M, Egashira K, Kataoka Y, Imaizumi T.
  • Journal Title: Circ Res 101 Pages: 348-356
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pulmonary inflammation and emphysema : role of the cytokines IL-18and IL-13. (2007)
  • Author(s): Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
  • Journal Title: Am J Respir Crit Care Med 176 Pages: 49-62
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (2007)
  • Author(s): Miyagi M, Aoyagi K, Kato S, Shirouzu K.
  • Journal Title: Int J Clin Oncol 12 Pages: 17-24
  • NAID: 10018565642
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema. (2007)
  • Author(s): Kinoshita T, Hoshino T, Imaoka H, Ichiki H, Okamoto M, Kawayama T, Yodoi J, Kato S, Aizawa H.
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 712-719
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation (2007)
  • Author(s): Kaneyuki U, Ueda S, Yamagishi S, Kato S, Fujimura T, Shibata R, Hayashida A, Yoshimura J, Kojiro M, Oshima K, Okuda S.
  • Journal Title: Vascul Pharmacol 46 Pages: 286-292
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model. (2007)
  • Author(s): Imaoka H
  • Journal Title: Biochem Biophys Res Commun 360 Pages: 525-530
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Postnatal blocking of interferon-gamma function prevented atherosclerotic plaque formation in apolipoprotein E-knockout mice. (2007)
  • Author(s): Koga M
  • Journal Title: Hypertens Res 30 Pages: 259-267
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of progression and stabilization of plaques by postnatal interferon-gamma unction blocking in ApoEknockout mice. (2007)
  • Author(s): Koga M
  • Journal Title: Circ Res 101 Pages: 348-356
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pulmonary inflammation and emphysema: role of the cytokines IL-18and IL-13. (2007)
  • Author(s): Hoshino T
  • Journal Title: Am J Respir Crit Care Med 176 Pages: 49-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (2007)
  • Author(s): Miyagi M
  • Journal Title: Int J Clin Oncol 12 Pages: 17-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thioredoxin prevents the development and progression of elastase-induced emphysema. (2007)
  • Author(s): Kinoshita T
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 712-719
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation (2007)
  • Author(s): Kaneyuki U
  • Journal Title: VaSCul Pharmacol 46 Pages: 286-292
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. (2007)
  • Author(s): Hoshino T, Kato S, Oka N, Imaoka H, Kinoshita T, Takei S, Kitasato Y, Kawayama T, Imaizumi T, Yamada K, Young HA, Aizawa H.
  • Journal Title: Am J Respir Crit Care Med 176 Pages: 49-62
  • Peer Reviewed
• [Journal Article] Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation. (2007)
  • Author(s): Kaneyuki U, Ueda S, Yamagishi S, Kato S, Fujimura T, Shibata R, Hayashida A, Yoshimura J, Kojiro M, Oshima K, Okuda S.
  • Journal Title: Vascul Pharmacol 46 Pages: 286-292
  • Peer Reviewed
• [Journal Article] Effects of thioredoxin on established airway remodeling in a chronicantigen exposure asthma model. (2007)
  • Author(s): Imaoka H, Hoshino T, Takei S, Sakazaki Y, Kinoshita T, Okamoto M, Kawayama T, Yodoi J, Kato S, Iwanaga T, Aizawa H.
  • Journal Title: Biochem Biophys Res Commun 360 Pages: 525-530
  • Peer Reviewed
• [Journal Article] Postnatal blocking of interferon-gamma function prevented atherosclerotic plaque formation in apolipoprotein E-knockout mice. (2007)
  • Author(s): Koga M, Kai H, Yasukawa H, Kato S, Yamamoto T, Kawai Y, Kusaba K, Seki Y, Kai M, Egashira K, Kataoka Y, Imaizumi T.
  • Journal Title: Hypertens Res 30 Pages: 259-267
  • Peer Reviewed
• [Journal Article] Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. (2006)
  • Author(s): Matsuguma K, Ueda S, Yamagishi S, Matsumoto Y, Kaneyuki U, Shibata R, Fujimura T, Matsuoka H, Kimoto M, Kato S, Imaizumi T, Okuda S.
  • Journal Title: J Am Soc Nephrol 17 Pages: 2176-2183
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCSl-deficient mice. (2006)
  • Author(s): Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A.
  • Journal Title: J Exp Med 203 Pages: 1391-1397
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor. (2006)
  • Author(s): Maeda M, Kato S, Fukushima S, Kaneyuki U, Fujii T, Kazanietz MG, Oshima K, Shigemori M.
  • Journal Title: Int J Mol Med 17 Pages: 559-566
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. (2006)
  • Author(s): Matsuguma K
  • Journal Title: J Am Soc Nephrol 17 Pages: 2176-2183
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. (2006)
  • Author(s): Hanada T
  • Journal Title: J Exp Med 203 Pages: 1391-1397
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbolester receptor. (2006)
  • Author(s): Maeda M
  • Journal Title: Int J Mol Med 17 Pages: 559-566
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of vascular smooth muscle proliferation and migration by beta2-chimaerin, a non-protein kinase C phorbol ester receptor. (2006)
  • Author(s): Maeda M, Kato S, Fukushima S, Kaneyuki U, Fujii T, Kazaniets MG, Oshima K, Shigemori M
  • Journal Title: Int J Mol Med 17 Pages: 559-566
• [Journal Article] Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease. (2006)
  • Author(s): Matsuguma K, Ueda S, Yamagishi S, Matsumoto Y, Kaneyuki U, Shibata R, Fujimura T, Matsuoka H, Kimoto M, Kato S, Imaizumi T, Okuda S
  • Journal Title: J Am Soc Nephrol 17 Pages: 2176-2183
• [Journal Article] Comparison of histological findings and parathyroid scintigraphy in hemodialysis patients with secondary hyparathyroid glands. (2005)
  • Author(s): Nishida H, Ishibashi M, Hiromatsu Y, Kaida H, Baba K, Miyake I, Ikedo H, Kato S, Fukami K, Iida S, Okuda S.
  • Journal Title: Endocr J 52 Pages: 223-228
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase : a novel anti-oxidative mechanism of PEDF. (2005)
  • Author(s): Yamagishi S, Nakamura K, Ueda S, Kato S, Imaizumi T.
  • Journal Title: Cell Tissue Res 320 Pages: 437-445
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Nitric Oxide Regulation System in Degenerative Lumbar Disease. (2005)
  • Author(s): Watanabe T, Kato S, Sato K, Nagata K.
  • Journal Title: Kurume Med J 52 Pages: 39-47
  • NAID: 130000097849
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Advanced glycation end-products attenuate htiman mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. (2005)
  • Author(s): Kume S, Kato S, Yamagishi S, Inagaki Y, Ueda S, Arima N, Okawa T, Kojiro M, Nagata K.
  • Journal Title: J Bone Miner Res 20 Pages: 1647-1658
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Related Articles, Links Abstract Thioredoxin suppresses airway hyperre sponsiveness and airway inflammation in asthma. (2005)
  • Author(s): Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S, Inoue H, Nakamura H, Yodoi J, Young HA, Aizawa H.
  • Journal Title: Biochem Biophys Res Commun 334 Pages: 1141-1148
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pigment epithelium-derived factor as a new diagnostic marker for melanocytic tumors. (2005)
  • Author(s): Tsuru M, Arima N, Toyozumi Y, Kato S.
  • Journal Title: Kurume Med J 52 Pages: 81-87
  • NAID: 130000097839
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparison of histological findings and parathyroid scintigraphy in hemodialysis patients with secondary hyperpar athyroid glands (2005)
  • Author(s): Nishida H
  • Journal Title: Endocr J 52 Pages: 223-228
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase: a novel anti-oxidative mechanism of PEDF. (2005)
  • Author(s): Yamagishi S
  • Journal Title: Cell Tissue Res 320 Pages: 437-445
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Nitric Oxide Regulation System in Degenerative Lumbar Disease. (2005)
  • Author(s): Watanabe T
  • Journal Title: Kurume Med J 52 Pages: 52-52
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. (2005)
  • Author(s): Kume S
  • Journal Title: J Bone Miner Res 20 Pages: 1647-1658
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Related Articles, Links Abstract Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma. (2005)
  • Author(s): Ichiki H
  • Journal Title: Biochem Biophys Res Commun 334 Pages: 1141-1148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pigment epithelium-derived factor as a new diagnostic marker for melanocytic tumors (2005)
  • Author(s): Tsuru M
  • Journal Title: Kurume Med J 52 Pages: 81-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pigment epithelium-derived factor (PEDF) blocks angiotensin II signaling in endothelial cells via suppression of NADPH oxidase : a novel anti-oxidative mechanism of PEDF (2005)
  • Author(s): Yamagishi SI, Nakamura K, Ueda S, Kato S他
  • Journal Title: Cell Tissue Res 320 Pages: 437-445
• [Journal Article] Nitric Oxide Regulation System in Degenerative Lumbar Disease (2005)
  • Author(s): Watanabe T, Kato S他
  • Journal Title: Kurume Med J 52 Pages: 39-47
  • NAID: 130000097849
• [Journal Article] Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone (2005)
  • Author(s): Kume S, Kato S他
  • Journal Title: J Bone Miner Res 20 Pages: 1647-1658
• [Journal Article] Thioredoxin suppresses airway hyperresponsiveness and airway inflammation in asthma (2005)
  • Author(s): Ichiki H, Hoshino T, Kinoshita T, Imaoka H, Kato S他
  • Journal Title: Biochem Biophys Res Commun 334 Pages: 1141-1148
• [Journal Article] Pigment epithelium-derived factor as a new diagnostic marker for melanocytic tumors (2005)
  • Author(s): Tsuru M, Arima N, Toyozumi Y, Kato S
  • Journal Title: Kurume Med J 52 Pages: 81-87
  • NAID: 130000097839
• [Journal Article] Down-regulation of p21Waf-1 protein facilitates IR-and UV-induced apoptosis in human squamous carcinoma cells. (2004)
  • Author(s): Izumaru S, Arima N, Toyozumi Y, Kato S, Morimatsu M, Nakashima T.
  • Journal Title: Int J Oncol 24 Pages: 1245-1255
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cyclin-dependent kinase inhibitor, p21Waf1, regulates vascular smooth muscle cell hypertrophy. (2004)
  • Author(s): Okamoto K, Kato S, Arima N, Fujii T, Morimatsu M, Imaizumi T.
  • Journal Title: Hypertens Res 27 Pages: 283-291
  • NAID: 10012925972
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Loss of caspase-8 activation pathway is a possible mechanismfor CDDP resistance in human laryngeal squamous cell carcinoma, Hep-2 cells. (2004)
  • Author(s): Toyozumi Y Arima N, Izumaru S, Kato S, morimatsu M, Nakashima D.
  • Journal Title: Int J Oncol 25 Pages: 721-728
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] AGEs activate mesangial TGF-β-Smad signaling via an angiotensin II-type I receptor interaction. (2004)
  • Author(s): Fukami K, Ueda S, Yamagishi S, Kato S, Inagaki Y Takeuchi M, Motomiya Y Bucala R, Iida S, Tamaki K, Imaizumi T, Cooper ME, Okuda S.
  • Journal Title: Kidney Int 66 Pages: 2137-2147
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Experimental gene therapy using p21Waf-1 gene for esophageal squamous cell carcinoma by gene gun technology. (2004)
  • Author(s): Tanaka Y, Fujii T, Yamana H, Kato S, Morimatsu M, Shirouzu K.
  • Journal Title: Int J Mol Med 14 Pages: 545-551
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosis. (2004)
  • Author(s): Eatasato Y, Hoshino T, Okamoto M, Kato S, Koda Y Nagata N, Kinoshita M, Koga H, Yoon DY, Asao H, Ohmoto H, Koga T, Rikimaru T, Aizawa H.
  • Journal Title: Am J Resp Cell Mol Biol 31 Pages: 619-625
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Down-regulation of p21Waf-1 protein facilitates IR- and UV-induced apoptosis in human squamous carcinoma cells. (2004)
  • Author(s): Izumaru S
  • Journal Title: Int J Oncol 24 Pages: 1245-1255
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cyclin-dependent kinase inhibitor, p21Waf1, regulates vascular smooth muscle cell hypertrophy. (2004)
  • Author(s): Okamoto K
  • Journal Title: Hypertens Res 27 Pages: 283-291
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma, Hep-2 cells. (2004)
  • Author(s): Toyozumi Y
  • Journal Title: Int J Oncol 25 Pages: 721-728
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] AGEs activate mesangial TGF-β-Smad signaling via an angiotensin II-type I receptor interactino. (2004)
  • Author(s): Fukami K
  • Journal Title: Kidney Int 66 Pages: 2137-2147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Experimental gene therapy using p21Waf-1 gene for esophageal squamous cell carcinoma by gene gun technology (2004)
  • Author(s): Tanaka Y
  • Journal Title: Am J Resp Cell Mol Biol 14 Pages: 545-551
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosi (2004)
  • Author(s): Kitasato Y
  • Journal Title: Am J Resp Cell Mol Biol 31 Pages: 619-625
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pneumoconiosis in rush mat workers exposed to clay dye "sendo"-dust : clinical, radiologic, and histopathologic features in seven patients. (2004)
  • Author(s): Fujimoto K, Muller NL, Kato S他
  • Journal Title: Chest 125 Pages: 737-743
• [Journal Article] Down-regulation of p21Waf-1 protein facilitates IR- and UV-induced apoptosis in human squamous carcinoma cells. (2004)
  • Author(s): Izumaru S, Arima N, Toyozumi Y, Kato S他
  • Journal Title: Int J Oncol 24 Pages: 1245-1255
• [Journal Article] Cyclin-dependent kinase inhibitor, p21Waf1, regulates vascular smooth muscle cell hypertrophy. (2004)
  • Author(s): Okamoto K, Kato S他
  • Journal Title: Hypertension Research 27 Pages: 283-291
  • NAID: 10012925972
• [Journal Article] Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma Hep-2 cells. (2004)
  • Author(s): Toyozumi Y, Arima N, Izumaru S, Kato S他
  • Journal Title: Int J Oncol 25 Pages: 721-728
• [Journal Article] AGEs activate mesangial TGF-β-Smad signaling via an angiotensin II-type I receptor interaction. (2004)
  • Author(s): Fukami K, Ueda S, Yamagishi S, Kato S他
  • Journal Title: Kidney Int 66 Pages: 2137-2147
• [Journal Article] Enhanced expression of IL-18 and its receptor in idiopathic pulmonary fibrosis. (2004)
  • Author(s): Kitasato Y, Hoshino T, Okamoto M, Kato S他
  • Journal Title: Am J Respir Cell Mol Biol 31 Pages: 619-625
• [Presentation] Beta2-chimaerin, a non-protein kinase C phorbol ester receptor, regulates proliferation and migration of vascular smooth musclecells. (2004)
  • Author(s): Maeda M, Kato S, Fujii T, Kazanietz MG, Shigemori S.
  • Organizer: The XXV International Congress of the Intern ational Academy of Pathology
  • Place of Presentation: Brisbane, Australia
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Advanced glycation end-products regulate proliferation and differentiation of human mesenchymal stem cells (2004)
  • Author(s): Kume S, Kato S, Yamagishi S, Inagaki Y, Nagata K.
  • Organizer: The XXV International Congress of the International Academy of Pathology
  • Place of Presentation: Brisbane, Australia
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Role of caspase-9 pathway in apoptosis of human glioma cells in duced by the inhibition of endogenous fibroblast growth factor signaling. (2004)
  • Author(s): Fukushima S, Kato S, Miyagi N, Aoki T, Sakata K, Shigemori M.
  • Organizer: 1st International Meeting on Tumor Progressi on & Therapeutic Resistance-2004
  • Place of Presentation: Philadelphia, PA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of proinflamma tory cytokine and chemokine in lysophosphatidic acid-treated vascular smooth muscle cells : A role ofmitogen-stimulated smooth muscle cells in the vascular inflammatory system. (2004)
  • Author(s): Kaneyuki U, Kato S, Ueda S, Yamagishi S, Inagaki Y, Yoshimura J, Imaizumit, Okuda S.
  • Organizer: European Congress of Pathology
  • Place of Presentation: Paris, France
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Beta2-chimaerin, a non-protein kinase C phorbol ester receptor, regulates proliferation and migration of vascular smooth muscle cells. (2004)
  • Author(s): Maeda M
  • Organizer: The XXV International Congress of the International Academy of Pathology
  • Place of Presentation: Brisbane, Australia
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Advanced glycation end-products regulate proliferation and differentiation of human mesenchymal stem cells. (2004)
  • Author(s): Kume S
  • Organizer: The XXV International Congress of the International Academy of Pathology
  • Place of Presentation: Brisbane, Australia
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of caspase-9 pathway in apoptosis of human glioma cells induced by the inhibition of endogenous fibroblast growth factor signaling. (2004)
  • Author(s): Fukushima S
  • Organizer: 1st International Meeting on Tumor Progression & Therapeutic Resistance 2004
  • Place of Presentation: Philadelphia, PA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of proinflammatory cytokine and chemokine in lysophosphatidic acid-treated vascular smooth muscle cells: A role of mitogen-stimulated smooth muscle cells in the vascular inflammatory system. (2004)
  • Author(s): Kaneyuki U
  • Organizer: European Congress of Pathology
  • Place of Presentation: Paris, France
  • Description: 「研究成果報告書概要(欧文)」より