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A Nation-wide estimation of the cumulative incidence and disease burden of the rotavirus gastroenteritis

Research Project

Project/Area Number 16590504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionThe University of Tokushima

Principal Investigator

ARISAWA Kokichi  The University of Tokushima, Institute of Health Biosciences, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (30203384)

Co-Investigator(Kenkyū-buntansha) NAKAGOMI Osamu  Nagasaki University, Institute of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (70143047)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsRotavirus / Gastroenteritis / Incidence rate / Meta-analysis / Vaccine / Intussusception / Epidemiology
Research Abstract

(1)Estimation of annual incidence, age-specific incidence rate, and the cumulative risk of rotavirus gastroenteritis among children in Japan.
Rotavirus gastroenteritis is a common childhood infection, but the exact morbidity of the disease is not well described in Japan. We aimed at estimating morbidity measures to determine the magnitude of rotavirus gastroenteritis. An estimate for acute infectious gastroenteritis of all causes, to which rotavirus gastroenteritis belongs, has been available since the enactment in 1999 of the Law concerning the Prevention of Infectious Diseases and Medical Care of Patients with Infectious Diseases. Using this estimate and another estimate for the detection proportion of rotavirus among outpatients with acute infectious gastroenteritis, we calculated the annual incidence, the age-specific annual incidence rate, and the cumulative risk by the age of 6 years for rotavirus gastroenteritis. The latter estimate was obtained by a meta-analysis of four indepen … More dent studies previously performed in Japan. According to our estimates, approximately 800,000 children in Japan under the age of 6 years visit pediatric practices or the outpatient department of hospitals because of rotavirus gastroenteritis at a rate of 11 cases/100 persons/year, and one in two children will visit pediatricians before they go to primary school. Such pediatrician visits most frequently occur at the age of 1 year (27 cases/100 persons/year). Thus, the magnitude of the burden of rotavirus disease among Japanese children is substantial.
(2)A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period (1978-2002).
The development of second-generation rotavirus vaccines requires knowledge of baseline incidence rates for intussusception in infants prior to vaccine introduction. To obtain such estimates we reviewed clinical records in a hospital that served as the major provider of paediatric beds in a local community in the northern part of Japan. During the 25-year period (1978-2002), there were 91 hospitalizations due to radiologically confirmed intussusception in children <5 years of age, of which 45% were <1 year of age. Assuming that all children with intussusception in the area had been admitted to this hospital, there were an average of 185 and 78 hospitalizations per 100000 person-years for children <1 year old and 5 years old respectively. There was period-to-period variability with no long-term secular trend in the incidence of intussusception. The incidence rate in Japan was among the highest thus far reported, providing further evidence of geographic variability. Less

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (22 results)

All 2006 2005 2004 Other

All Journal Article (19 results) Book (3 results)

  • [Journal Article] A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period (1978-2002).2006

    • Author(s)
      Nakagomi T
    • Journal Title

      Epidemiology and Infection 134(1)

      Pages: 57-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4year longitudinal study among atomic bomb survivors in Nagasaki, Japan.2006

    • Author(s)
      Arisawa K
    • Journal Title

      Cancer Science 97

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A high incidence of intussusception in Japan as studied in a sentinel hospital over a 25-year period (1978-2002).2006

    • Author(s)
      Nakagomi T.
    • Journal Title

      Epidemiology and Infection 134(1)

      Pages: 57-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan.2006

    • Author(s)
      Arisawa K
    • Journal Title

      Cancer Science 97(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multi-prefectural spread of gastroenteritis outbreaks attributable to a single genogroup II norovirus strain from a tourist restaurant in Nagasaki, Japan.2005

    • Author(s)
      Hirakawa Y
    • Journal Title

      Journal of Clinical Microbiology 43(3)

      Pages: 1093-1098

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Background exposure to PCDDs/PCDFs/PCBs and its potential health effects : a review of epidemiologic studies.2005

    • Author(s)
      Arisawa K
    • Journal Title

      Journal of Medical Investigation 52(1,2)

      Pages: 10-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Relationship between the type of urinary incontinence and falls among frail elderly women in Japan.2005

    • Author(s)
      Takazawa K.
    • Journal Title

      Journal of Medical Investigation 52(3,4)

      Pages: 165-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multi-prefectural spread of gastroenteritis outbreaks attributable to a single genogroup II norovirus strain from a tourist restaurant in Nagasaki, Japan.2005

    • Author(s)
      Hirakata Y.
    • Journal Title

      Journal of Clinical Microbiology 43(3)

      Pages: 1093-1098

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Background exposure to PCDDs/PCDFs/PCBs and its potential health effects : a review of epidemiologic studies.2005

    • Author(s)
      Arisawa K.
    • Journal Title

      Journal of Medical Investigation 52(1,2)

      Pages: 10-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multi-prefectural spread of gastroenteritis outbreaks attributable to a single genogroup II norovirus strain from a tourist restaurant in Nagasaki, Japan.2005

    • Author(s)
      Hirakata Y
    • Journal Title

      Journal of Clinical Microbiology 43(3)

      Pages: 1093-1098

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Journal Article] Estimation of annual incidence, age-specific incidence rate, and the cumulative risk of rotavirus gastroenteritis among children in Japan.2004

    • Author(s)
      Yokoo M
    • Journal Title

      Japanese Journal of Infectious Diseases 57(4)

      Pages: 166-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] an outbreak of gastroenteritis during school trip caused by serotype G2 group A rotavirus.2004

    • Author(s)
      Mikami T
    • Journal Title

      Journal of Medical Virology 73(3)

      Pages: 460-464

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan.2004

    • Author(s)
      Takamura N.
    • Journal Title

      European Journal of Nutrition 43(5)

      Pages: 285-287

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Estimation of annual incidence, age-specific incidence rate, and the cumulative risk of rotavirus gastroenteritis among children in Japan.2004

    • Author(s)
      Yokoo M.
    • Journal Title

      Japanese Journal of Infectious Diseases 57(4)

      Pages: 166-171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An outbreak of gastroenteritis during school trip caused by serotype G2 group A rotavirus.2004

    • Author(s)
      Mikami T.
    • Journal Title

      Journal of Medical Virology 73(3)

      Pages: 460-464

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An outbreak of gastroenteritis during school trip caused by serotype G2 group A rotavirus.2004

    • Author(s)
      Mikami T
    • Journal Title

      Journal of Medical Virology 73(3)

      Pages: 460-464

    • Related Report
      2005 Annual Research Report 2004 Annual Research Report
  • [Journal Article] Abnormal folic acid homocysteine metabolism as maternal risk factors for Down syndrome in Japan.2004

    • Author(s)
      Takamura N
    • Journal Title

      European Journal of Nutrition 43(5)

      Pages: 285-287

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Randomized controlled trial of swaddling versus massage in the management of excessive crying in infants with cerebral injuries.2004

    • Author(s)
      Ohgi S
    • Journal Title

      Archives of Disease in Childhood 89(3)

      Pages: 212-216

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human T-cell lymphotropic virus type-1 infection and risk of cancer : 15.4 year longitudinal study among atomic bomb survivors in Nagasaki, Japan.

    • Author(s)
      Arisawa K.
    • Journal Title

      Cancer Science (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 医科細菌学第4版(南江堂)2006

    • Author(s)
      有澤 孝吉
    • Publisher
      国際感染症と公衆衛生. 感染の疫学.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 医科細菌学第4版 国際感染症と公衆衛生.感染の疫学2006

    • Author(s)
      有澤 孝吉
    • Publisher
      南江堂(印刷中)
    • Related Report
      2005 Annual Research Report
  • [Book] 標準微生物学2005

    • Author(s)
      有澤 孝吉
    • Publisher
      医学書院(印刷中)
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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