| Project/Area Number |
16590604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saga University |
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Principal Investigator |
TODA Shuji Saga University, Internal Medicine, Associate Professor, 医学部, 助教授 (80188755)
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| Co-Investigator(Kenkyū-buntansha) |
IWAKIRI Rhuuji Saga University, Internal Medicine, Associate Professor, 医学部, 助教授 (70232642)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Air-liquid interface / Luminal factor / mucosal epithelium of alimentary tracts / Growth / Differentiation / Apoptosis / Culture / Survival / アポトーシ |
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| Research Abstract |
Air-liquid interface (ALI) is a microenvironment for mucosal surface of alimentary tracts. We have shown that ALI microenvironment promotes the survival, growth and differentiation of gastric mucosal epithelium. In this study, we propose that ALI is a luminal factor of gastric mucosal epithelium. Our present project has demonstrated that ALI promoted the survival, proliferation and differentiation of mucosal epithelium of small and large intestines, while ALI did not affect the apoptosis. The ALI-promoted growth was intimately associated with MAP kinase cascade activation. The ALI-induced functional differentiation was closely related to the increased expression of aquaporin and pendrin molecules. These results suggest that ALI is an important luminal factor for mucosal epithelial cell types of alimentary tracts.
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