Remodeling of skeletal muscle-molecular mechanisms of muscle fiber type switching
| Project/Area Number |
16590853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
FURUTAMA Daisuke Osaka Medical College, Faculty of Medicine, Research Associate, 医学部, 助手 (70291987)
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| Co-Investigator(Kenkyū-buntansha) |
OHSAWA Nakaaki Aino Institute for Aging Research, President, 藍野短期大学・藍野加齢医学研究所, 所長 (90010090)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | slow fiber / fast fiber / gene expression / regeneration / 転写因子 / cis-element / 骨格筋 / 分化 |
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| Research Abstract |
In this study we investigated the molecular mechanisms of muscle fiber type switching, especially slow to fast fiber switching. Using reporter plasmids for slow or fast fiber specific genes, we screened the cis-element for muscle fiber type specific gene expression. For example, the myoglobin gene promoter region must contain the slow fiber specific cis-element(s), whereas the myosin heavy chain 2A gene promoter could contain the fast fiber specific cis-element. We conducted these experiments several times and found the several cis-elements muscle fiber type specific gene expression.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] A Chronic Progressive Case of Enteroviral Limbic Encephalitis Associated with Autoantibody to Glutamate Receptor epsilon22007
Author(s)
Nakajima H, Hosoya M, Takahashi Y, Matsuyama K, Tagami M, Ishida S, Furutama D, Sugino M, Kimura F, Shinoda KI, Hanafusa T.
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Journal Title
Eur Neurol. 57(4)
Pages: 238-240
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Novel Therapeutic Strategy for Stroke in Rats by Bone Marrow Stromal Cells and Ex Vivo HGF Gene Transfer with HSV-1 Vector.2006
Author(s)
Ming-Zhu Zhao, Naosuke Nonoguchi, Naokado Ikeda, Takuji Watanabe, Daisuke Furutama, Daisuke Miyazawa, Hiroshi Funakoshi, Yoshinaga Kajimoto, Toshikazu Nakamura, Mari Dezawa, Masa-Aki Shibata, Yoshinori Otsuki, Robert S. Coffin, Wei-Dong Liu, Toshihiko Kuroiwa, Shin-Ichi Miyatake.
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Journal Title
J Cerebral Blood Flow and Metabolism 26
Pages: 1176-88
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Bone marrow stromal cells that enhanced FGF-2 secretion by Herpes Simplex virus vector improve neurological outcome after transient focal ischemia in rats2005
Author(s)
Naokado Ikeda, Naosuke Nonoguchi, Ming-Zhu Zhao, Takuji Watanabe, Yoshinaga Kajimoto, Daisuke Furutama, Fumiharu Kimura, Mari Dezawa, Robert S. Coffin, Yoshinori Otsuki, Toshihiko Kuroiwa, Shin-ichi Miyatake.
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Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Post-Ischemic Intraventricular Administration of FGF-2 Expressing Adenoviral Vectors Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Cerebral Ischemia in Rats.2004
Author(s)
Takuji Watanabe, Yasuaki Okuda, Naosuke Nonoguchi, Ming Zhu Zhao, Yoshinaga Kajimoto, Daisuke Furutama, Hiroyuki Yukawa, Masa-Aki Shibata, Yoshinori Otsuki, Toshihiko Kuroiwa, Shin-Ichi Miyatake.
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Journal Title
J Cerebral Blood Flow and Metabolism 24
Pages: 1205-13
Description
「研究成果報告書概要(欧文)」より
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