Regulation of hematopoiesis and tumorigenesis by Bcl6 and AP-1 gene family.
| Project/Area Number |
16590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
OKADA Seiji Kumamoto University, Center for AIDS Research, Div.of Hematopoiesis, Professor, エイズ学研究センター, 教授 (50282455)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | BCL6 / AP-1 / Dendritic cells / Hematopoietic stem cells |
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| Research Abstract |
The proto-oncogene bcl-6 and c-fos are ubiquitously expressed in various tissues, and play important role for the differentiation, proliferation, apoptosis and oncogeneisis. In this study, I focused on the function of bcl-6 and c-fos for the hematologic cells, using transgenic and gene deficient mice.
1.Function of Bcl-6 on erythroid differentiation
Bcl-6 detected in the TER119highCD71high subset of erythroblasts in the spleen of neonatal mice may be required to retain the erythroblasts in the cell proliferation stage.
2.Function of Bcl-6 on dendritic cell differentiation
Bcl-6 deficient mice showed decreased umber of dendritic cells in spleen. Especially CD8+ subfraction of dendriti cells was completely deficient.
3.Function of c-fos on B cell differentiation
Using H2-c-fos transgenic mice, we showed that c-Fos positively regulated blimp-1 expression and terminal differentiation of activated B cells.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] A role for c-Fos/Ap-1 in B lymphocyte terminal differentiation.2005
Author(s)
Ohkubo Y, Arima M, Arguni E, Okada S, Yamashita K, Asari S, Obata S, Sakamoto A, Hatano M, O-Wang J, Ebara M, Saisho H, Tokuhisa T
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Journal Title
J Immunol 174(12)
Pages: 7703-7710
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice.2005
Author(s)
Koda M, Okada S, Nakayama T, Koshizuka S, Kamada T, Nishio Y, Someya Y, Yoshinaga K, Okawa A, Mariya H, Yamazaki M
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Journal Title
NeuroReport 16(16)
Pages: 1761-1767
Description
「研究成果報告書概要(欧文)」より
Related Report
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