Research Project
Grant-in-Aid for Scientific Research (C)
Although both of an aplastic anemia (AA) and a myelodysplastic syndrome(MDS)-refractory anemia(RA) are bone marrow failure syndrome, disease-overlapping between these disease has been discussed. Aim of this study is clarified that etiology and clinical characteristics of MDS-developed AA patient and residual hemopoiesis in these bone marrow failure syndrome.According to database that has been established by Japanese Society of Pediatric Hematology, a prognosis of MDS developed AA patient depends on chromosome abnormalities. Trisomy 8 is good, however monosomy 7 is poor prognostic marker. Incidence of MDS development in RA patients was low. Clinical and hematological response for immunosuppressive therapy (IST) was suspected as high as 50-60% in both AA and MDS-RA. MCV was also high in both type of bone marrow failure because MCV reflects ineffective erythropoiesis.For the purpose of evaluation for residual hemopoiesis, multidimensional flow cytometry analysis (MDF) was introduced in a small-scale study. As a tentative result, MDF technique has a possibility to detect exhaustion of immature myeloid cells at an AA diagnosis and was able to follow hemopoiesis recovery after IST, and also detect aberrant Fells on abnormal maturation pathway.
All 2008 2007 2006 2005
All Journal Article (17 results) (of which Peer Reviewed: 9 results) Presentation (26 results) Book (8 results)
Blood 111(3)
Pages: 1054-1059
日本小児血液学会雑誌 22(1)
Pages: 53-62
10025700378
Pages: 63-69
Jpn J Pediatr Hematol 22(1)
Blood 111・3
日本小児血液学会雑誌 22・1
日本小児血液学会雑誌 21(5/6)
Pages: 247-251
10025699964
血液・腫瘍科 55(5)
Pages: 587-592
40019064354
Jpn J Pediatr Hematol 21(516)
Ketsueki Shuyo-ka 55(5)
血液・腫瘍科 55・5
日本小児血液学会雑誌 21・5/6
Br J Haematol 135(5)
Pages: 693-696
