Tailor-made therapy of tolerance induction in hen's egg allergy with hypoallergenic egg white
| Project/Area Number |
16591063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
URISU Atsuo Fujita Health University, School of Medicine, Professor, 医学部, 教授 (20193972)
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| Co-Investigator(Kenkyū-buntansha) |
TSUGE Ikuya Fujita Health University, School of Medicine, Associate Professor, 医学部, 助教授 (00231431)
KONDO Yasuo Fujita Health University, School of Medicine, Associate Professor, 医学部, 助教授 (30301641)
KAKAMI Michiko Fujita Health University, School of Medicine, Assistant, 医学部, 助手
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Egg allergy / Oral immunological tolerance / Heated and ovomucoid-depleted egg white / CISH / DNA microarray / Oral immunotherapy / Real-time PCR / 食物アレルギー / DNAマイクロアレイ / 鶏卵白アレルギー / SOCS family / トランスクリプトーム解析 / Th1サイトカイン / Th2サイトカイン / IL-4 / IL-13 / IFN-γ / オリゴDNAマイクロアレイ |
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| Research Abstract |
We noted that cytokine inducible SH2-containing protein (CISH) expression in allergen-stimulated CD4+ T cells from hen's egg-allergic patients were significantly increased in both mRNA and protein levels compared with that from non-allergic children. CISH may contribute to understanding the pathogenesis of hen's egg allergy.
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Report
(4 results)
Research Products
(30 results)
