| Project/Area Number |
16591100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OURA Hajimu The University of Tokushima, Dept of Dermatology, Assistant Professor, 医学部・歯学部附属病院, 講師 (20284284)
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| Co-Investigator(Kenkyū-buntansha) |
ARASE Seiji The University of Tokushima, Dept of Dermatology, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 (90108887)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | RNAi / Angiogenesis factor / Psoriasis vulgaris / DDS |
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| Research Abstract |
RNA interference (RNAi) mediated by small interfering RNAs (siRNA) is a potent technology allowing the silencing of mammalian genes with great specificity. Technology that allows the downregulation of expression of specific genes expressed in the skin would have numerous application ranging from improving our understanding of basic biology of the skin to providing therapy for psoriasis vulgaris.
Angiogenesis is a prominent feature of a number of inflammatory human disease, including rheumatoid arthritis, psoriasis. Upreguration of vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), a member of VEGF family, have been found in several conditions associated with pathological angiogenesis; however, its distinct role in the control of angiogenesis has remained unclear. To investigate the expression of VEGF and PIGF, the lesional skins of psoriasis patients were investigated with ELISA assay. We found strong upreguration of VEGF and PIGF protein levels in the lesional skin of psoriasis vulgaris patients, and designed siRNAs for VEGF or PIGF. Moreover, we test new vehicles for their accurate delivery.
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