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Mechanism of the ability of atypical antipsychotic drugs to improve working memory and social function in schizophrenia

Research Project

Project/Area Number 16591126
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama (2005-2006)
Toyama Medical and Pharmaceutical University (2004)

Principal Investigator

SUMIYOSHI Tomiki  University of Toyama, Department of Neuropsychiatry, Lecturer, 医学部附属病院, 講師 (80286062)

Co-Investigator(Kenkyū-buntansha) MATSUI Mie  University of Toyama, Department of Psychology, Associate Professor, 大学院医学薬学研究部, 助教授 (70209485)
KAWASAKI Yasuhiro  University of Toyama, Department of Neuropsychiatry, Lecturer, 医学部附属病院, 講師 (80242519)
TANAKA Kodai  University of Toyama, Department of Neuropsychiatry, Assistant Professor, 大学院医学薬学研究部, 助手 (80377275)
KURACHI Masayoshi  University of Toyama, Department of Neuropsychiatry, Professor, 大学院医学薬学研究部, 教授 (80019603)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsatypical antipsychotic drug / schizophrenia / cognitive function / QOL / verbal learning and memory / verbal fluency / event-related potential / functional brain imaging / 不飽和脂肪酸 / クオリティー・オブ・ライフ / 言語記憶 / 記憶の体制化 / セロトニン / ワーキングメモリー / 生物学的マーカー
Research Abstract

The authors investigated the effect of atypical antipsychotic drugs (AAPDs) on cognitive function in patients with schizophrenia. We found that monotherapy with olanzapine (OLZ) or perospirone was associated with improvements in attention and quality of life in these patients.
The effect of ziprasidone and OLZ on memory organization in patients with schizophrenia was studied. The multidimensional scaling (MDS) analysis was used to convert the order of verbal outputs from the. Category Fluency Task with "ANIMAL" names into a cognitive map representing organization of long-term semantic memory. Treatment with either drug resulted in appearance of semantically meaningful clusters, such as "wild vs. domesticity," which was not evident before treatment in subjects with schizophrenia. There was also an improvement in quality of life in these patients.
We investigated the anatomical distribution of P300 current source density, by means of Low Resolution Electromagnetic Tomography (LORETA), before and after treatment with OLZ in subjects with schizophrenia. Normal control subjects demonstrated a left dominant laterality of P300 current density in the temporal regions, while this pattern was not evident in subjects with schizophrenia. Treatment with OLZ for 6 months restored the left dominant laterality pattern of P300 current density, which was accompanied with improvements in verbal learning memory, quality of life, and psychopathology, in the patients. The results of this study provides the first demonstration that the ability of some AAPDs to treat memory deficits of schizophrenia is likely to be associated with the change in the anatomical distribution of electrophysiological activity.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (22 results)

All 2007 2006 2005 2004 Other

All Journal Article (22 results)

  • [Journal Article] 日本語版単語記憶学習検査(Japanese Verbal Learning Test)代替版の作成2007

    • Author(s)
      松井三枝, 住吉太幹, 他
    • Journal Title

      精神医学 49

      Pages: 31-34

    • NAID

      40015202876

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Verbal memory deficits in a preadolescent case of lesions of the left parahippocampal gyrus associated with a benign tumor.2006

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 30

      Pages: 733-736

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Atypical antipsychotic drugs and organization of long-term semantic memory : Multidimensional scaling and cluster analyses of category fluency performance in schizophrenia.2006

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      International Journal of Neuropsychopharmacology 9

      Pages: 677-683

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Electrical brain activity and response to olanzapine in schizophrenia : A study with LORETA images of P300.2006

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 30

      Pages: 1299-1303

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Atypical antipsychotic drugs and organization of long-term semantic memory : Multidimensional scaling and cluster analyses of category fluency performance in schizophrenia.2006

    • Author(s)
      Sumiyoshi, et al.
    • Journal Title

      International Journal of Neuropsychopharmacology 9

      Pages: 677-683

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Verbal memory deficits in a preadolescent case of lesions of the left parahippocampal gyrus associated with a benign tumor2006

    • Author(s)
      Sumiyoshi, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30

      Pages: 733-736

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impairment of event schema in patients with schizophrenia : Examination of script for shopping at supermarket2006

    • Author(s)
      Matsui, Sumiyoshi, et al.
    • Journal Title

      Psychiatry. Research 143

      Pages: 179-187

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Electrical brain activity and response to olanzapine in schizophrenia : A study with LORETA images of P3002006

    • Author(s)
      Sumiyoshi, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30

      Pages: 1299-1303

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Perospirone in the treatment of schizophrenia : Effect on verbal memory organization.2006

    • Author(s)
      Araki, Yamasue, Sumiyoshi et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 30

      Pages: 204-208

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia.2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      International Journal of Neuropsychopharmacology 8

      Pages: 451-455

    • NAID

      10016942875

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Disorganization of semantic memory underlies alogia in schizophrenia; An analysis of verbal fluency performance in Japanese subjects.2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Schizophrenia Research 74

      Pages: 91-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Disorganization of semantic memory underlies alogia in schizophrenia ; An analysis of verbal fluency performance in Japanese subjects.2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Schizophrenia Research 74

      Pages: 91-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Disorganization of semantic memory underlies alogia in schizophrenia : an analysis of verbal fluency performance in Japanese subjects.2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Schizophrenia Research 74

      Pages: 91-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      International Journal of Neuropsychopharmacology 8

      Pages: 451-455

    • NAID

      10016942875

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 第2世代抗精神病薬と認知機能2005

    • Author(s)
      住吉ら
    • Journal Title

      臨床精神医学 34

      Pages: 427-438

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Disorganization of semantic memory underlies alogia in schizophrenia ; An analysis of verbal fluency performance in Japanese subjects2005

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Schizophrenia Research 74

      Pages: 91-100

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prediction of changes in memory performance by plasma homovanillic acid levels in clozapine-treated patients with schizophrenia.2004

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Psychopharmacology 177

      Pages: 79-83

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of hypertension and obesity on the development of diabetes mellitus in patients treated with atypical antipsychotic drugs.2004

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Journal of Clinical Psychopharmacology 24

      Pages: 452-454

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of orthography on the verbal fluency performance in schizophrenia : Examination using Japanese patients2004

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Schizophrenia Research 69

      Pages: 15-22

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prediction of changes in memory performance by plasma homovanillic acid levels in clozapine-treated patients with schizophrenia2004

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      Psychopharmacology 177

      Pages: 79-83

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Serotonin 1A receptors in memory function2004

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      American Journal of Psychiatry 161

      Pages: 1505-1505

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prediction of the ability of clozapine to treat negative symptoms from plasma glycine and serine levels in schizophrenia

    • Author(s)
      Sumiyoshi et al.
    • Journal Title

      International Journal of Neuropsychopharmacology (in press)

    • NAID

      10016942875

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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