Relationship between impulsivity and lipid metabolism, and immune function among the young patients with eating disorders, depression and social anxiety disorder

• Project/Area Number: 16591153
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka City University
• Principal Investigator: NEGATA Toshihiko Osaka City University, Graduate School of Medicine, Department of Neuropsychiatry, Associate Professor (80237528)
• Co-Investigator(Kenkyū-buntansha): MATSUNAGA Hisato Osaka City University, Graduate School of Medicine, Department of Neuropsychiatry, Lecturer (20254394) ; 池谷 俊哉 大阪市立大学, 大学院医学研究科, 講師 (80295708)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: bulimia nervosa / Psycho-neuro-immunology / Adiponectin / brain-derived neurotrophic factor / Anxiety / Anxiety / Bulimia nervosa / Leptin / eating disorders / Dulimia nervosa / leptin / adiponectin / tumor necrosis factor

Research Abstract

Previous our studies suggested the possibilities that psychological factors rather than the abnormal eating behaviors contribute immunological functions. Alternatively, other factors such adipocytokines (adiponectin, leptin, resistin) or brain-derived neurotrophic factor (BDNF) might contribute anxiety or depressive mood in eating disorder patients. In this current study, we investigates the relationship between abnormal eating behaviors, psychological states (general anxiety and depressive mood), immunological functions, adipocytokines and BDNF in the patients with bulimia nervosa cross-sectionally as well longitudinally.
Subjects consisted of 16 female patients with bulimia nervosa and 9 controls. Eight patients with bulimia nervosa were longitudinally studied. All were given written informed.
There were no significant differences in CD4/CD8 ratio of lymphocyte, stimulation index of lymphocyte proliferative responses, tumor necrosis factor, adiponectin, leptin soluble receptor, and resistin between bulimia nervosa and controls. However, patients with bulimia nervosa showed significantly lower leptin and BDNF than controls. In addition, BDNF was significantly (inversely) related with frequencies of binge and vomiting. In longitudinal study, low BDNF recovered according to improvement of abnormal eating behaviors and psychological states.
Contrast with hypotheses, this study suggested that BDNF might be influenced by negative psychological states and abnormal eating behaviors. Alternatively, BDNF rather than the adipocytokines or cytokines negatively influenced psychological states. To resolve these mechanisms, longitudinal study in larger sample is needed.

Research Products

• [Journal Article] Cross-cultural study of the offensive subtype of social anxiety disorder:proposal and reliability of Nagoya-Osaka diagnostic criteria (2008)
  • Author(s): Kinoshita, Y., et. al.15番目
  • Journal Title: J Nerv Ment Dis 196 Pages: 7-313
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Psychological and weight-related characteristics of patients with anorexia nervosa-restricting type who later develop bulimia nervosa (2008)
  • Author(s): Nishimura, H., et. al.7番目
  • Journal Title: Biopsychosoc Med 2 Pages: 5-5
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cross-cultural study of conviction subtype Taijin Kyofu: proposal and reliability of Nagoya-Osaka diagnostic criteria for social anxiety disorder (2008)
  • Author(s): Kinoshita, Y., Chen, J., Rapee, R. M., Bogels, S., Schneier, F., R., Choy, Y., Kwon, J. H., Liu, X., Schramm, E., Chavira, D. A., Nakano, Y., Watanabe, N., Ietzugu, T., Ogawa, S., Emmelkamp, P., Zhang, J., Kingdon, D., Nagata, T., Furukawa, T. A
  • Journal Title: J New Ment Dis 196 Pages: 307-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Psychological and weight-related characteristics of patients with anorexia nervosa-restricting type who later develop bulimia nervosa (2008)
  • Author(s): Nishimura, H., Komaki, G., Ando, T., Nakahara, T., Oka, T., Kawai, K., Nagata. T., Nishizono, A., Okamoto, Y., Okabe, K., Koide, M., Yamaguchi, C., Saito, S., Ohkuma, K., Nagata, K., Naruo, T., Takii, M., Kiriike, N., Ishikawa, T
  • Journal Title: Biopsychosoc Med 2
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cross-cultural study of the offensive subtype of social anxiety disorder: proposal and reliability of Nagoya-Osaka diagnostic criteria (2008)
  • Author(s): Kinoshita, Y., et. al. (15番目
  • Journal Title: J Nerv Ment Dis 196 Pages: 307-313
  • Peer Reviewed
• [Journal Article] Psychological and weight-related characteristics of patients with anorexi a nervosa-restricting type who later develop bulimia nervosa (2008)
  • Author(s): Nishimura, H., et. al. (7番目
  • Journal Title: Biopsychosoc Med 2 Pages: 5-5
  • Peer Reviewed
• [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients (2007)
  • Author(s): Tbmillaga, K., et. al.11番目
  • Journal Title: Inflammopharmacology 15 Pages: 84-89
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 摂食障害における社会不安障害 (2007)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 49 Pages: 129-135
  • NAID: 40015301111
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 摂食障害についての最近の話題摂食障害に先行する併存症の治療、社会不安障害を例に. (2007)
  • Author(s): 永田 利彦
  • Journal Title: 精神神経誌 109 Pages: 1129-1134
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients (2007)
  • Author(s): Tominaga, K., Higuchi, K., Iketani, T., Ochi, M., Kadouchi, K., Tanigawa, T., Shiba, M., Watanabe, T., Fujiwara, Y., Oshitani, N., Naeata, T., Kiriike, N., Arakawa, T
  • Journal Title: Inflammopharmacology 15 Pages: 84-89
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Social anxiety disorder among the patients with eating disorders (2007)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishin-igaku (in Japanese) 49(2) Pages: 129-135
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients (2007)
  • Author(s): Tominaga, K., et. al. (11番目
  • Journal Title: Inflammopharmacology 15 Pages: 84-89
  • Peer Reviewed
• [Journal Article] 摂食障害に先行する併存症の治療、社会不安障害を例に (2007)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神神経誌 109 Pages: 1129-1134
  • NAID: 10024577539
• [Journal Article] 摂食障害における社会不安障害 (2007)
  • Author(s): 永田利彦, ほか
  • Journal Title: 精神医学 49 Pages: 129-135
  • NAID: 40015301111
• [Journal Article] An open trial of paroxetine for the "offensive subtype" of taijin kyofusho and social anxiety disorder. (2006)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Depression and Anxiety 23 Pages: 168-174
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship between plasma concentrations of cytokines,ratio of CD4 and CD8,lymphocyte proliferative responses,and depressive and anxiety state in bulimia nervosa. (2006)
  • Author(s): Nagata, T., et. al.
  • Journal Title: J Psychosom Res, 60 Pages: 99-103
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 社会不安スペクトラムの治療 (2006)
  • Author(s): 永田 利彦
  • Journal Title: 精神神経誌 108 Pages: 766-771
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] An open trial of paroxetine for the "offensive subtype" of taiiin kyofusho and social anxiety disorder (2006)
  • Author(s): Nagata, T., van Vliet, I., et. al.
  • Journal Title: Depression and Anxiety 23 Pages: 168-174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between plasma concentrations of cytokines, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive and anxiety state in bulimia nervosa (2006)
  • Author(s): Nagata, T., et. al.
  • Journal Title: J Psychosom Res 60 Pages: 99-103
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Psycho-neuro-immunilogical aspects of eating disorders (2006)
  • Author(s): Nagata, T., Yamada, H
  • Journal Title: Psychosomatic Medicine, Proceeding of the 18th World Congress on Psychosomatic Medicine (Kobe). Elsevier. (Kubo C., and Kuboki T Ed) Netherlands Pages: 279-284
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between plasma concentrations of cytokines, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive and anxiety state in bulimia nervosa. (2006)
  • Author(s): Nagata T et al.
  • Journal Title: Journal of Psychosomatic Research 60 Pages: 99-103
• [Journal Article] An open trial of paroxetine for the 'offensive subtype' of Taijin Kyofusho and social anxiety disorder (2006)
  • Author(s): Nagata T et al.
  • Journal Title: Depression and Anxiety 23 Pages: 168-174
• [Journal Article] 社会不安障害-自己主張が必要な時代とのつきあい方- (2006)
  • Author(s): 永田利彦
  • Journal Title: こころの臨床アラカルト 25 Pages: 399-408
• [Journal Article] 摂食障害とサイトカイン (2006)
  • Author(s): 永田利彦, 切池信夫
  • Journal Title: ホルモンと臨床 54 Pages: 335-342
  • NAID: 10017333823
• [Journal Article] Effect of milnacipran on insight and stress coping strategy in patients with Taijin Kyofusho (2005)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Int J Psych Clin Pract 9 Pages: 193-198
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Is "relationship fear" unique to Japan?Symptom factors and patient clusters of social anxiety disorder among the Japanese clinical population. (2005)
  • Author(s): Sakurai, A., Nagata, T., et. al.
  • Journal Title: J Affect Disord 87 Pages: 131-137
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 身体醜形障害のcomorbidityを有する社会不安障害について (2005)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 47 Pages: 1113-1118
  • NAID: 40006975207
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of milnacipran on insight and stress coping strategy in patients with Taiiin Kvofusho (2005)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Int J Psych Clin Pract 9 Pages: 193-198
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Is "relationship fear" unique to Japan? Symptom factors and patient clusters of social anxiety disorder among the Japanese clinical population (2005)
  • Author(s): Sakurai, A., Nagata, T., et. al.
  • Journal Title: J Affect Disord 87 Pages: 131-137
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Repetitive self-mutilation syndrome and multi-impulsivity among eating disorder patients; Cross-cultural perspective. (2005)
  • Author(s): Nagata, T
  • Journal Title: In Burrows, GD, Bosanac, P, Beumont PJV Editted Selected paper from the 1st Asian Pacific Eating Disorders Congress Melbourne
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comorbidity of body dysmorphic disorder among the patients with social anxiety disorder (2005)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishin-igaku (in Japanese) 47(10) Pages: 1113-1118
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of milnacipran on insight and stress coping strategy in patients with Taijin Kyofusho. (2005)
  • Author(s): Nagata T et al.
  • Journal Title: Int J Psych Clin Pract 6 Pages: 193-198
• [Journal Article] Is "relationship fear" unique to Japan? Symptom factors and patient clusters of social anxiety disorder among the Japanese clinical population. (2005)
  • Author(s): Sakurai A, Nagata T, et al.
  • Journal Title: J Affect Disord 87 Pages: 131-137
• [Journal Article] 身体醜形障害のcomorbidityを有する社会不安障害について (2005)
  • Author(s): 永田利彦, ほか
  • Journal Title: 精神医学 47 Pages: 1113-1118
  • NAID: 40006975207
• [Journal Article] 繰り返し自傷症候群へのolanzapineの有効性 (2004)
  • Author(s): 永田 利彦, 他
  • Journal Title: 臨床精神医学 33 Pages: 1609-1615
  • NAID: 40006549905
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 社会不安障害に対する薬物療法:古典的対人恐怖、ひきこもりとの関連、 (2004)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 46 Pages: 933-939
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 社会不安障害におけるパーソナリティー障害1大うつ病性障害との関連 (2004)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 46 Pages: 685-690
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 社会不安障害患者における大うつ病性障害の生涯診断 (2004)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 46 Pages: 381-387
  • NAID: 40006160968
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 社会不安障害における価値観:古典的対人恐怖との関連 (2004)
  • Author(s): 永田 利彦, 他
  • Journal Title: 精神医学 46 Pages: 141-147
  • NAID: 40006097392
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cross-Cultural Aspects of Social Anxiety Disorder. (2004)
  • Author(s): Seedat, S., Nagata., T
  • Journal Title: In Social Anxiety Disorder - More Than Shyness; Psychopathology, Pathogenesis, and Management Pages: 117-130
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Olanzapine in treatment of repetitive self-mutilation syndrome (in Japanese) (2004)
  • Author(s): Nagata, et. al.
  • Journal Title: Rinsho-Seishinigaku 33(12) Pages: 1609-1615
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Predictors of response to pharmacotherapy in social anxiety disorder: Retrospective chart study in relationship with TKS firm belief (third) type and social withdrawal (housebound lifestyle) (in Japanese) (2004)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishin-igaku 46(9) Pages: 933-939
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Personality disorders in social anxiety disorder patients: Relationship withy major depressive disorder.(in Japanese) (2004)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishinigaku 46(7) Pages: 685-690
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] (2004). Lifetime diagnosis of major depressive disorder among social anxiety disorder patients (Lifetime axis I comorbidity among Japanese SAD patients) (in Japanese (2004)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishin-igaku 46(4) Pages: 381-387
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] (2004) Social value in the patients with social anxiety disorder: Relationship with TKS firm belief (third) type. (in Japanese) (2004)
  • Author(s): Nagata, T., et. al.
  • Journal Title: Seishin-igaku 46(2) Pages: 141-147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 繰返し自傷症候群へのolanzapineの有効性 (2004)
  • Author(s): 永田利彦ほか
  • Journal Title: 臨床精神医学 33(12) Pages: 1609-1615
• [Journal Article] 社会不安障害に対する薬物療法、古典的対人恐怖ひきこもりとの関連 (2004)
  • Author(s): 永田利彦ほか
  • Journal Title: 精神医学 46(9) Pages: 933-939
• [Journal Article] 社会不安障害におけるパーソナリティー障害 (2004)
  • Author(s): 永田利彦ほか
  • Journal Title: 精神医学 46(7) Pages: 685-690
• [Journal Article] 社会不安障害における大うつ病性障害の生涯診断 (2004)
  • Author(s): 永田利彦ほか
  • Journal Title: 精神医学 46(4) Pages: 381-387
• [Journal Article] Effect of milnacipran on insight and stress coping strategy in patients with TICS
  • Author(s): Nagata T et al.
  • Journal Title: Int.J.Psych Clin Pract (印刷中)
• [Journal Article] Is "relationship fear" unique to Japan? Symptom factors and patient clusters of SAD among the Japanese clinical population
  • Author(s): Sakurai A, Nagata T, et al.
  • Journal Title: J.Allect Disord (印刷中)
• [Presentation] 摂食障害における弁証法的行動療法DBT (2007)
  • Author(s): 永田 利彦
  • Organizer: シンポジウム「摂食障害治療の新たな展開」
  • Place of Presentation: 京都府立医科大学
  • Year and Date: 2007-10-21
• [Presentation] Motivational Interviewing for the chronic eating disorder patients (2007)
  • Author(s): Nagata, T
  • Organizer: World Congress of Behavioral and Cognitive Therapies 2004
  • Place of Presentation: Kobe
  • Year and Date: 2007-07-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 摂食障害における社会不安障害の併存 (2007)
  • Author(s): 永田 利彦
  • Organizer: 第103回日本精神神経学会総会、シンポジウム「摂食障害についての最近の話題」
  • Place of Presentation: 高知県立県民文化ホール
  • Year and Date: 2007-05-17
• [Presentation] Relationship between plasma concentrations of cytokines,ratio of CD4 and CD8,lymphocyte proliferative responses,and depressive and anxiety state in bulimia nervosa (2005)
  • Author(s): Nagata, T.
  • Organizer: XIII WORLD CONGRESS OF PSYCHIATRY
  • Place of Presentation: Egypt Cairo
  • Year and Date: 2005-09-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PSYCHONEUROIMMUNOLOGICAL ASPECTS OF EATING DISORDER (2005)
  • Author(s): Nagata, T.
  • Organizer: The 18th World Congress on Psychosomatic Medicine,
  • Place of Presentation: Kobe
  • Year and Date: 2005-08-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PSYCHO-NEURO-IMMUNOLOGICAL ASPECTS OF EATING DISORDERS (2005)
  • Author(s): Nagata, T
  • Organizer: The 18th World Congress on Psychosomatic Medicine
  • Place of Presentation: Kobe
  • Year and Date: 2005-08-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Relationship between plasma concentrations of cytokines, ratio of CD4 and CD8, lymphocyte proliferative responses, and depressive and anxiety state in bulimia nervosa (2005)
  • Author(s): Nagata, T
  • Organizer: XIII WORLD CONGRESS OF PSYCHIATRY (WPA)
  • Place of Presentation: Cairo, Egypt
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prediction of response to pharmacotherapy in social anxiety disorder in relationship to Taijin Kyofusho and social withdrawal (2004)
  • Author(s): Nagata, T.
  • Organizer: World Psychiatric Association International Congress-Treatments in Psychiatry:an Update,
  • Place of Presentation: Florence,Italy
  • Year and Date: 2004-11-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Motivational Interviewing for the chronic eating disorder patients (2004)
  • Author(s): Nagata, T.
  • Organizer: World Congress of Behavioral and Cognitive Therapies
  • Place of Presentation: Kobe
  • Year and Date: 2004-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Minacipran for insight of Taijin Kyofusho:The relationship with Stress Coping Strategy (2004)
  • Author(s): Nagata, T.
  • Organizer: XXIVth Collegium Internationale Neuro-Psychoph armacologicum,
  • Place of Presentation: Paris,France
  • Year and Date: 2004-06-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Milnacipran for insight of Taijin Kyofusho: The relationship with Stress Coping Strategy (2004)
  • Author(s): Nagata, T., et. al.
  • Organizer: XXIVth Collegium Internationale Neuro-Psychopharmacologicum
  • Place of Presentation: Paris, France
  • Year and Date: 2004-06-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prediction of response to pharmacotherapy in social anxiety disorder in relationship to Taijin Kyofusho and social withdrawal (2004)
  • Author(s): Nagata, T
  • Organizer: WPA International Congress - Treatments in Psychiatry
  • Place of Presentation: Florence
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 摂食行動異常の評価、摂食障害の入院治療-精神科医の立場から「摂食障害、新しい診断と治療のABC」 (2007)
  • Author(s): 永田 利彦
  • Publisher: 最新医学社
• [Book] Psycho-neuro-immunological Aspects of Eating Disorders (International Congress Series ICS 1287016 Psychosomatic Medicine) (2006)
  • Author(s): Nagata, T., Yamada, H.
  • Publisher: Elsevier
• [Book] 社会不安障害(上島国利, 久保木富房監修)(レジデントハンドブック、抗不安薬・睡眠薬・抗うつ薬・気分安定薬の使い方) (2006)
  • Author(s): 永田利彦
  • Publisher: アルタ出版
• [Book] 健康管理室で役立つこころの医学(野村ほか編) (2005)
  • Author(s): 永田利彦
  • Publisher: 南江堂
• [Book] Cross-Cultural Aspects of Social Anxiety Disorder.In Social Anxiety Disorder-More Than Shyness;Psychopathology, Pathogenesis, and Management (2004)
  • Author(s): Seedat, S.&Nagata, T.
  • Publisher: Marcel Dekkker:New York.
  • Description: 「研究成果報告書概要(和文)」より