Neural mechanisms of drug-seeking behavior elicited by drug-associated environmental stimuli and development of new strategy to prevent conditioned stimulus-elicited drug-seeking
| Project/Area Number |
16591166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MIYATA Hisatsugu Jikei University School of Medicine, Department of Medicine, Associate Professor (70239416)
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| Co-Investigator(Kenkyū-buntansha) |
KOGA Minako The Jikei University, Department of Medicine, Assistant Professor (30277032)
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,750,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | nicotine / conditioned place preference / intracranial self-stimulation / conditioned stimulus / brain reward system / medial forebrain bundle / lateral hypothalamus / rat / ドパミンD3受容体部分刺激薬 / 条件づけ / 環境刺激 / 内側前頭前野 / 腹側被蓋野 / 扁桃体 / 側坐核 / 自発運動量 / ドパミン / 6-ハイドロキシドパミン |
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| Research Abstract |
The purpose of the present study was to investigate the involvement of environmental stimuli associated with nicotine (NCT) in NCT dependence. In a conditioned place preference (CPP) paradigm, NCT-associated environmental stimuli maintained a place preference for NCT up to 6 months. Destruction of DA system with 6-OHDA in the basolateral amygdala (AMY) and ventral tegmental area (VTA) decreased a place preference for NCT elicited by NCT-associated environmental stimuli. Disruption of CPPs elicited by NCT-associated environmental stimuli in rats treated with 6-OHDA was reversed by administration of the training dose of NCT (0.4 mg/kg, s.c.). In an intracranial self-stimulation (ICSS) paradigm, NCT-associated environmental stimuli decreased lateral hypothalamus ICSS thresholds, whereas NCT-unrelated environmental stimuli did not. BP 897, a D3 partial agonist, administered prior to the conditioning sessions with NCT tended to block an ability of NCT-associated environmental stimuli to decrease medial forebrain bundle ICSS thresholds. These results indicate 1) the environmental stimuli associated with NCT function as powerful cues to maintain NCT-seeking behavior through stimulating a brain reward system, 2) the AMY and the VTA DA system are involved in NCT-seeking behavior elicited by the environmental stimuli associated with NCT, 3) BP 897 is a candidate as a new drug to prevent NCT-seeking behavior by blocking an association between NCT and the environmental stimuli.
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Report
(5 results)
Research Products
(41 results)
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[Journal Article] Psychosocial withdrawal characterictice of nicotine compared with alcohol and caffeine2008
Author(s)
Miyata, Hiyata, Hironaka, Naoyuki, Takada, Kohji, Miyasato, Katsumasa, Nakamura, Kohichi, Yanagita, Tomoji
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Journal Title
Annals of the New York Academy of Sciences (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] ニコチン依存の特徴2005
Author(s)
宮田 久嗣, 河野 純子, 柳田 知司
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Journal Title
日本神経精神薬理学雑誌 25
Pages: 213-219
NAID
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Presentation] Psychosocial withdrawal characterictice of nicotine compared with alcohol and caffeine2007
Author(s)
Miyata, Hiyata, Hironaka, Naoyuki, Takada, Kohji, Miyasato, Katsumasa, Nakamura, Kohichi, Yanagita, Tomoji
Organizer
1st Annual International Drug Abuse Research Society and International Society for Neurochemistry Satellite Meeting
Place of Presentation
Merida(Mexico)
Year and Date
2007-08-08
Description
「研究成果報告書概要(欧文)」より
Related Report
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